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Effects of cisplatin on urinary thromboxane B2 excretion*
Clinical Pharmacology & Therapeutics, 1995Thromboxane A2 (TxA2) is implicated in the pathogenesis of various forms of drug-induced renal damage. Based on previous functional studies, we postulated that cis-dichlorodiammineplatinum (cisplatin) induces intrarenal TxA2 synthesis. To test this hypothesis, we measured urinary excretion of thromboxane B2 (TxB2), the stable inactive metabolite of ...
B, Blöchl-Daum +7 more
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Enzyme-immunoassay of thromboxane B2 at the picogram level
Prostaglandins, 1985A highly sensitive and reproducible enzyme-immunoassay for the measurement of thromboxane B2 was developed. Thromboxane B2 (TxB2) was coupled with beta-D-galactosidase by mixed anhydride reaction. Thromboxane B2-antiserum was generated in rabbits and used at a final dilution of 1:480,000.
M, Sawada, T, Inagawa, J C, Frölich
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Synthesis of thromboxane B2 in uraemia and the effects of dialysis
Thrombosis Research, 1983The generation of thromboxane B2 (TxB2) from its natural precursor, arachidonic acid, was studied in vitro in order to assess further the prostaglandin pathway in the platelets of patients with chronic renal failure. Some, but not all patients with conservatively treated uraemia synthesised significantly less TxB2 then controls and the same patients ...
M, Winter +4 more
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Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man
Biochimica et Biophysica Acta (BBA) - General Subjects, 1989Thromboxane (TX) B2, the chemically stable hydration product of pro-aggregatory TXA2, undergoes two major pathways of metabolism in man, resulting in the formation of 2.3-dinor-TXB2 and 11-dehydro-TXB2, respectively. We have measured the excretion of the latter during the infusion of exogenous TXB2 over a 50-fold dose range in order to examine the ...
CIABATTONI, Giovanni +5 more
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Nihon Geka Gakkai zasshi, 1986
Plasma thromboxane B2 (TxB2) level were measured in patients with various disease, and its changes were investigated in patients who underwent various operations. The following results were obtained. Plasma TxB2 values in patients with TAO, heart disease, and malignant disease were significantly elevated compared with healthy control.
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Plasma thromboxane B2 (TxB2) level were measured in patients with various disease, and its changes were investigated in patients who underwent various operations. The following results were obtained. Plasma TxB2 values in patients with TAO, heart disease, and malignant disease were significantly elevated compared with healthy control.
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[Enzyme immunoassay for thromboxane B2].
Zeitschrift fur medizinische Laboratoriumsdiagnostik, 1989A sensitive and specific enzyme immunoassay for TXB2, the stable degradation product of thromboxane A2, was developed, in which the hapten molecule was labeled with pure peroxidase. After competitive binding to antibody between enzyme-labeled and free TXB2, the immunoreactive product was precipitated by double antibody technique, and the enzyme ...
G, Hellthaler +3 more
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1982
Abstract The preparation of 2,3,4,5-tetranor-TxB 2 is described. Its conversion into d 3 -MO derivative allows the preparation of a deuterium-labeled product for use in mass fragmentography. An example is given of the potential application of this standard for the simultaneous measurement of this catabolite from the dinor catabolite and TxB 2 by ...
C.R. Pace-Asciak, N.S. Edwards
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Abstract The preparation of 2,3,4,5-tetranor-TxB 2 is described. Its conversion into d 3 -MO derivative allows the preparation of a deuterium-labeled product for use in mass fragmentography. An example is given of the potential application of this standard for the simultaneous measurement of this catabolite from the dinor catabolite and TxB 2 by ...
C.R. Pace-Asciak, N.S. Edwards
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1995
2,3-Dinor-thromboxane B2 is the most abundant urinary metabolite of thromboxane B2 in man. As with the primary prostaglandins, venipuncture leads to large artifactual release of thromboxane B2. When monitoring thromboxane B2 release, therefore, measurement of this late-appearing metabolite can avoid acute fluctuation that may be seen in direct ...
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2,3-Dinor-thromboxane B2 is the most abundant urinary metabolite of thromboxane B2 in man. As with the primary prostaglandins, venipuncture leads to large artifactual release of thromboxane B2. When monitoring thromboxane B2 release, therefore, measurement of this late-appearing metabolite can avoid acute fluctuation that may be seen in direct ...
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Urinary thromboxane B2 and 2,3-dinor-thromboxane B2 in the neonate born at full-term age.
Eicosanoids, 1990We have developed a method for measurement of urinary 2,3-dinor-TXB2, which is a reflection of the actual rate of TXA2 synthesis by platelets in vivo. This determination was based on purification by high-pressure liquid chromatography and on measurement by RIA. After validation of the assay, we established the range of urinary Tx metabolites in healthy
C, Van Geet +3 more
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