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Facile indazole-endowed thiadiazole hybrid derivatives as antibacterial, anti-diabetic and thymidine phosphorylase inhibitors: An insight to experimental, in-vitro biological potential and computational approaches. [PDF]

Saudi Pharm J
Arshad S, Maalik A, Rehman W, Khan Y, Alanazi MM, Sarfraz H, Rasheed L.   +6 more
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Calyculin A Induces Premature Chromosome Condensation and Chromatin Compaction in G₁-Phase HeLa Cells without Histone H1 Phosphorylation

Kochanova NY, Vermeren M, Prevo B, Ustun I, Webb S, Xie L, Earnshaw WC, Paulson JR.   +7 more
europepmc   +1 more source

Genome-scale metabolic modelling of trimethoprim’s mode of action reveals free ATP salvaged to restore purine pool

Carter C, Singh D, Wain J, Langridge GC.
europepmc   +1 more source

Single-molecule sequencing maps replication dynamics across the fission yeast genome, including centromeres

Díez-Santos I, Thiyagarajan S, Rogers AM, Watson AT, Carr AM, Nieduszynski CA.   +5 more
europepmc   +1 more source

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Prior exposure to thymidine analogs and didanosine is associated with long-lasting alterations in adipose tissue distribution and cardiovascular risk factors

AIDS (London), 2019
Background: Thymidine analogs and didanosine (ddI) have been associated with redistribution of body fat from subcutaneous adipose tissue (SAT) to visceral adipose tissue (VAT), which, in turn, is a risk factor for cardiovascular disease.
M. Gelpi, S. Afzal, A. Fuchs, J. Lundgren, A. Knudsen, Ninna Drivsholm, A. Mocroft, A. Lebech, Birgitte Lindegaard, J. T. Kühl, P. Sigvardsen, L. Køber, B. Nordestgaard, K. Kofoed, S. Nielsen   +14 more
semanticscholar   +1 more source

The thymidine phosphorylating kinases

Biochimica et Biophysica Acta, 1961
Abstract The pattern of the phosphorylation reactions when supernatant fractions from leukaemic spleen and lymph nodes of mice are incubated with an ATP regenerating system and [2- 14 C]thymidine has been studied. The results indicate that TDP is not an intermediate in the formation of TTP, the latter compound being formed by pyrophosphate addition ...
P A, BIANCHI, J A, BUTLER, A R, CRATHORN, K V, SHOOTER   +3 more
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Feedback inhibition of thymidine kinase by thymidine triphosphate

Experimental Cell Research, 1963
THE search for rate-controlling enzyme systems in the overall synthesis of DNA has led a number of investigators to study the reactions in the sequence from Tdr to dTTP. Little duplication of effort has occurred despite the similarity in overall objectives.
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Mitochondrial-specific thymidine kinase

Archives of Biochemistry and Biophysics, 1973
Abstract Thymidine kinase activity has been demonstrated in purified mitochondria prepared from animal tissue, wild-type tissue culture cells, and BrdU-resistant cell lines. The BrdU-resistant cell lines lack a soluble cytoplasmic thymidine kinase present in wild-type cells, but continue to exhibit the minor mitochondrial activity.
A J, Berk, B J, Meyer, D A, Clayton
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Mitochondrial Thymidine Kinase Inhibitors

Current Topics in Medicinal Chemistry, 2005
Mitochondrial thymidine kinase or TK-2 belongs to the family of mammalian deoxynucleoside kinases (dNKs) that catalyze the phosphorylation of deoxynucleosides to their corresponding deoxynucleoside monophosphates by gamma-phosphoryl transfer of ATP.
María-Jesús, Pérez-Pérez, Ana-Isabel, Hernández, Eva-María, Priego, Fátima, Rodríguez-Barrios, Federico, Gago, María-José, Camarasa, Jan, Balzarini   +6 more
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