Thymidine Kinase+/− Mammalian Cell Mutagenicity Assays for Assessment of Nanomaterials [PDF]
Frontiers in Toxicology, 2022 Graphical ...
Tao Chen +2 more
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Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dogs [PDF]
Journal of Veterinary Internal MedicineBackground Although the importance of early diagnosis of malignant tumors is a major concern, an easily accessible in‐house method has not been established.
Yoonhee Kim +12 more
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Thymidine kinase 1 through the ages: a comprehensive review [PDF]
Cell & Bioscience, 2020 Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and disease progression. TK1 is involved in cellular
Eliza E. Bitter +4 more
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Optimization of Thymidine Kinase-Based Safety Switch for Neural Cell Therapy [PDF]
Cells, 2022 Cell therapies based on pluripotent stem cells (PSC), have opened new therapeutic strategies for neurodegenerative diseases. However, insufficiently differentiated PSC can lead to tumor formation.
Manon Locatelli +7 more
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Development of a Novel Recombinant Full-Length IgY Monoclonal Antibody against Human Thymidine Kinase 1 for Automatic Chemiluminescence Analysis on a Sandwich Biotin-Streptavidin Platform for Early Tumour Discovery [PDF]
Journal of Immunology Research, 2023 Serum thymidine kinase 1 protein (STK1p) concentration has been used successfully as a reliable proliferating serum biomarker in early tumour discovery and clinical settings.
Xiangbin Wang +12 more
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Persistence of Thymidine Kinase Activity in Mitochondria of a Thymidine Kinase-Deficient Derivative of Mouse L Cells [PDF]
Proceedings of the National Academy of Sciences, 1972 The cell line LM(TK - ) Cl 1D, a derivative of mouse L fibroblasts deficient in thymidine kinase (EC 2.7.1.21) that shows very little thymidine kinase activity in extracts of whole cells as compared to the parental line, and that does not incorporate thymidine or 5-bromodeoxyuridine into nuclear DNA, has maintained ...
Barbara Attardi, Giuseppe Attardi
openalex +6 more sources
Increased levels of thymidine kinase 1 in malignant cell-derived extracellular vesicles [PDF]
Biochemistry and Biophysics ReportsExtracellular vesicles (EVs), whose main subtypes are exosomes, microparticles, and apoptotic bodies, are secreted by all cells and harbor biomolecules such as DNA, RNA, and proteins.
Ehsan Manouchehri Doulabi +7 more
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Fission yeast strains with circular chromosomes require the 9-1-1 checkpoint complex for the viability in response to the anti-cancer drug 5-fluorodeoxyuridine. [PDF]
PLoS ONE, 2017 Thymidine kinase converts 5-fluorodeoxyuridine to 5-fluorodeoxyuridine monophosphate, which causes disruption of deoxynucleotide triphosphate ratios.
Hossain Mohammad Shamim +5 more
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Thymidine plaque autoradiography of thymidine kinase-positive and thymidine kinase-negative herpesviruses [PDF]
Journal of Clinical Microbiology, 1983 Plaques formed by herpes simplex virus (HSV), pseudorabies virus, and varicella-zoster virus were studied by plaque autoradiography after [14C]thymidine labeling. Standard thymidine kinase-positive (TK+) viruses and TK- mutants of HSV types 1 and 2 and pseudorabies virus were studied, including cell cultured viruses and viruses isolated from animals ...
F. A. Fralish +3 more
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Clinical Case Reports, 2021 Adenovirus‐mediated herpes simplex virus thymidine kinase gene therapy (ADV‐TK) in combination with interventional treatment could relieve the symptoms in patients with widespread splenic metastasis.
Qing Liu +5 more
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