Fission yeast strains with circular chromosomes require the 9-1-1 checkpoint complex for the viability in response to the anti-cancer drug 5-fluorodeoxyuridine. [PDF]
PLoS ONE, 2017 Thymidine kinase converts 5-fluorodeoxyuridine to 5-fluorodeoxyuridine monophosphate, which causes disruption of deoxynucleotide triphosphate ratios.
Hossain Mohammad Shamim +5 more
doaj +4 more sources
Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dogs [PDF]
Journal of Veterinary Internal MedicineBackground Although the importance of early diagnosis of malignant tumors is a major concern, an easily accessible in‐house method has not been established.
Yoonhee Kim +12 more
doaj +2 more sources
Thymidine Kinase+/− Mammalian Cell Mutagenicity Assays for Assessment of Nanomaterials [PDF]
Frontiers in Toxicology, 2022 Graphical ...
Tao Chen +2 more
doaj +2 more sources
Late-onset thymidine kinase 2 deficiency: a review of 18 cases [PDF]
Orphanet Journal of Rare Diseases, 2019 Background TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 gene are responsible for the ‘myopathic form’ of the mitochondrial depletion ...
Cristina Domínguez-González +23 more
doaj +3 more sources
Predictive levels of vascular endothelial growth factor (VEGF), thymidine kinase 1 (TK1) with interleukin-6 (IL-6), plasma T cells, NK cells as well as B cells in treating diffuse large B-cell lymphoma receiving rituximab [PDF]
Journal of Medical BiochemistryBackground: The aim was to explore the effect of rituximab in combination with chemotherapy in treating diffuse large B-cell lymphoma and levels of vascular endothelial growth factor (VEGF), thymidine kinase 1(TK1) with interleukin-6 (IL-6), plasma T ...
Tian Lihua +3 more
doaj +2 more sources
Optimization of Thymidine Kinase-Based Safety Switch for Neural Cell Therapy [PDF]
Cells, 2022 Cell therapies based on pluripotent stem cells (PSC), have opened new therapeutic strategies for neurodegenerative diseases. However, insufficiently differentiated PSC can lead to tumor formation.
Manon Locatelli +7 more
doaj +2 more sources
Thymidine kinase 1 through the ages: a comprehensive review [PDF]
Cell & Bioscience, 2020 Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and disease progression. TK1 is involved in cellular
Eliza E. Bitter +4 more
doaj +2 more sources
Increased levels of thymidine kinase 1 in malignant cell-derived extracellular vesicles [PDF]
Biochemistry and Biophysics ReportsExtracellular vesicles (EVs), whose main subtypes are exosomes, microparticles, and apoptotic bodies, are secreted by all cells and harbor biomolecules such as DNA, RNA, and proteins.
Ehsan Manouchehri Doulabi +7 more
doaj +2 more sources
Putting drug resistant epithelial herpes keratitis in the spotlight: A case series
American Journal of Ophthalmology Case Reports, 2022 Purpose: To strengthen the sparse evidence on acyclovir (ACV) resistance, especially in recalcitrant herpetic keratitis (HK), by describing the clinical course of 3 genotypically proven ACV resistant HK cases.
Ivo De Clerck +6 more
doaj +1 more source
Thymidine plaque autoradiography of thymidine kinase-positive and thymidine kinase-negative herpesviruses [PDF]
Journal of Clinical Microbiology, 1983 Plaques formed by herpes simplex virus (HSV), pseudorabies virus, and varicella-zoster virus were studied by plaque autoradiography after [14C]thymidine labeling. Standard thymidine kinase-positive (TK+) viruses and TK- mutants of HSV types 1 and 2 and pseudorabies virus were studied, including cell cultured viruses and viruses isolated from animals ...
R B, Tenser +3 more
openaire +2 more sources