Results 11 to 20 of about 62,555 (239)
Structural Basis for the Dual Thymidine and Thymidylate Kinase Activity of Herpes Thymidine Kinases [PDF]
Structure, 2003 Crystal structures of equine herpesvirus type-4 thymidine kinase (EHV4-TK) in complex with (i). thymidine and ADP, (ii). thymidine and SO(4) and the bisubstrate analogs, (iii). TP(4)A, and (iv). TP(5)A have been solved. Additionally, the structure of herpes simplex virus type-1 thymidine kinase (HSV1-TK) in complex with TP(5)A has been determined ...
Gardberg, A. +4 more
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Tk-deleted pseudorabies virus retains high pathogenicity in rats
Journal of Veterinary Research, 2021 The pseudorabies virus (PRV) gene encoding thymidine kinase (tk) is an important virulence-associated factor. Attenuation of PRV in susceptible animals is a frequent result of tk deletion.
Zhang Lirong +11 more
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Thymidine kinase in breast cancer [PDF]
British Journal of Cancer, 1990 The enzyme thymidine kinase is associated with DNA synthesis. Thymidine kinase serum levels were studied in normal controls (n = 20), patients with primary breast cancer (n = 60), patients with systemic breast cancer (n = 20) and as a non-cancer disease control group in patients with inflammatory gastrointestinal disorders (n = 20).
Kim L. O'Neill +4 more
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Mitochondrial DNA Depletion Syndrome
Pediatric Neurology Briefs, 2002 Twenty patients with myopathic mitochondrial DNA (mtDNA) depletion syndrome (MDS) were screened for mutations in thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) genes at Columbia University, New York, NY.
J Gordon Millichap
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Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer. [PDF]
PLoS ONE, 2018 INTRODUCTION:Successful inhibition of thymidylate synthase (TS) by pemetrexed, a TS inhibitor, results in a reproducible transient burst or "flare" in thymidine salvage pathway activity at 2 hrs.
Xiao Chen, Yizeng Yang, Sharyn I Katz
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Molecular Therapy: Oncolytics, 2017 Multiple myeloma is a malignancy of plasma cells of the bone marrow. Although the prognosis is variable, no curative therapy has been defined. Vaccinia virus infects cancer cells and kills such cells in a variety of ways.
Muneyoshi Futami +5 more
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INDUCIBILITY OF THYMIDINE KINASE BY THYMIDINE AS A FUNCTION OF INTERPHASE STAGE [PDF]
The Journal of Cell Biology, 1965 Thymidine may act as an inducer of thymidine kinase activity in cells of higher plants. The general response is demonstrable in a randomly developing cell population such as is found in germinating wheat embryos. If a synchronously developing cell population is studied, however, potentially inducible cells are found to be susceptible to the inductive ...
Yasuo Hotta, Herbert Stern
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BMC Neuroscience, 2022 Background Deoxythymidine triphosphate (dTTP) is an essential building block of DNA, and defects in enzymes involved in dTTP synthesis cause neurodegenerative disorders.
Junmei Hu Frisk +4 more
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Feedback inhibition of thymidine kinase by thymidine triphosphate
Experimental Cell Research, 1963 THE search for rate-controlling enzyme systems in the overall synthesis of DNA has led a number of investigators to study the reactions in the sequence from Tdr to dTTP. Little duplication of effort has occurred despite the similarity in overall objectives.
Van R. Potter, David H. Ives, P.A. Morse
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Thymidine Kinase in IDU Resistance.
Experimental Biology and Medicine, 1965 SummaryStudies were done to determine whether 5-iodo-2′-deoxyuridine resistance of herpes simplex in rabbit corneal infection was a function of thymidine kinase deficiency in the viral genome. Herpes simplex virus passed in rabbit kidney cells in the presence of 5-iodo-2′-deoxyuridine was resistant to it in vivo although this resistant virus induced ...
Herbert E. Kaufman +1 more
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