Results 11 to 20 of about 946,060 (233)

Thymidine Kinase+/− Mammalian Cell Mutagenicity Assays for Assessment of Nanomaterials [PDF]

Frontiers in Toxicology, 2022
Graphical ...
Tao Chen, Maria Dusinska, Rosalie Elespuru   +2 more
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Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dogs [PDF]

Journal of Veterinary Internal Medicine
Background Although the importance of early diagnosis of malignant tumors is a major concern, an easily accessible in‐house method has not been established.
Yoonhee Kim, Wonhee Lee, Byunggak Kim, Bonghwan Jang, Kyung‐Rok Yu, Hong Sook Kim, Minok Ryu, Yein Oh, Kyoungwon Seo, Chul Park, Ulsoo Choi, Dongha Bhang, Hwayoung Youn   +12 more
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Optimization of Thymidine Kinase-Based Safety Switch for Neural Cell Therapy [PDF]

Cells, 2022
Cell therapies based on pluripotent stem cells (PSC), have opened new therapeutic strategies for neurodegenerative diseases. However, insufficiently differentiated PSC can lead to tumor formation.
Manon Locatelli, Flavien Delhaes, Ophélie Cherpin, Margaret E. Black, Stéphanie Carnesecchi, Olivier Preynat-Seauve, Youssef Hibaoui, Karl-Heinz Krause   +7 more
doaj   +2 more sources

Development of a Novel Recombinant Full-Length IgY Monoclonal Antibody against Human Thymidine Kinase 1 for Automatic Chemiluminescence Analysis on a Sandwich Biotin-Streptavidin Platform for Early Tumour Discovery [PDF]

Journal of Immunology Research, 2023
Serum thymidine kinase 1 protein (STK1p) concentration has been used successfully as a reliable proliferating serum biomarker in early tumour discovery and clinical settings.
Xiangbin Wang, Shan Li, Rui Zhao, Huijun Li, Peng Gao, Cuicui Jin, Cong Fang, Yongping Liu, Ailian Hei, Ji Zhou, Jin Li, Ellen He, Sven Skog   +12 more
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Increased levels of thymidine kinase 1 in malignant cell-derived extracellular vesicles [PDF]

Biochemistry and Biophysics Reports
Extracellular vesicles (EVs), whose main subtypes are exosomes, microparticles, and apoptotic bodies, are secreted by all cells and harbor biomolecules such as DNA, RNA, and proteins.
Ehsan Manouchehri Doulabi, Louise Dubois, Liza Löf, Tanay Kumar Sinha, George Mickhael Harinck, Per Stålhandske, Anders Larsson, Masood Kamali-Moghaddam   +7 more
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Thymidine kinase 1 as a tumor biomarker: technical advances offer new potential to an old biomarker.

Biomarkers in Medicine, 2018
Thymidine kinase 1 (TK1) is a key enzyme in DNA precursor synthesis. It is upregulated during the S phase of the cell cycle and its presence in cells is an indicator of active cell proliferation.
K. Jagarlamudi, Martin Shaw
semanticscholar   +1 more source

Retrospective natural history of thymidine kinase 2 deficiency

Journal of Medical Genetics, 2018
Background Thymine kinase 2 (TK2) is a mitochondrial matrix protein encoded in nuclear DNA and phosphorylates the pyrimidine nucleosides: thymidine and deoxycytidine.
C. Garone, Robert W Taylor, A. Nascimento, J. Poulton, C. Fratter, C. Domínguez-González, J. Evans, M. Loos, P. Isohanni, A. Suomalainen, D. Ram, M Imelda Hughes, R. Mcfarland, E. Barca, C. Lopez Gomez, S. Jayawant, Neil D Thomas, Adnan Y. Manzur, K. Kleinsteuber, Miguel A. Martín, T. Kerr, G. Gorman, E. Sommerville, P. Chinnery, M. Hofer, C. Karch, J. Ralph, Y. Cámara, M. Madruga‐Garrido, J. Domínguez-Carral, C. Ortez, S. Emperador, J. Montoya, A. Chakrapani, Joshua Kriger, R. Schoenaker, B. Levin, John L P Thompson, Yuelin Long, S. Rahman, Maria Alice Donati, S. Dimauro, M. Hirano   +42 more
semanticscholar   +1 more source

Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders

BMC Neuroscience, 2022
Background Deoxythymidine triphosphate (dTTP) is an essential building block of DNA, and defects in enzymes involved in dTTP synthesis cause neurodegenerative disorders.
Junmei Hu Frisk, Stefan Örn, Gunnar Pejler, Staffan Eriksson, Liya Wang   +4 more
doaj   +1 more source

Tunneling nanotubes: an alternate route for propagation of the bystander effect following oncolytic viral infection

Molecular Therapy: Oncolytics, 2016
Tunneling nanotubes (TNTs) are ultrafine, filamentous actin-based cytoplasmic extensions which form spontaneously to connect cells at short and long-range distances.
Justin Ady, Venugopal Thayanithy, Kelly Mojica, Phillip Wong, Joshua Carson, Prassanna Rao, Yuman Fong, Emil Lou   +7 more
doaj   +1 more source

Putting drug resistant epithelial herpes keratitis in the spotlight: A case series

American Journal of Ophthalmology Case Reports, 2022
Purpose: To strengthen the sparse evidence on acyclovir (ACV) resistance, especially in recalcitrant herpetic keratitis (HK), by describing the clinical course of 3 genotypically proven ACV resistant HK cases.
Ivo De Clerck, Vincent Walgrave, Robert Snoeck, Graciela Andrei, Johan Blanckaert, Evelyne Mulliez, Heleen Delbeke   +6 more
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