Results 21 to 30 of about 116,563 (263)

The Enhanced Tumor Specificity of TG6002, an Armed Oncolytic Vaccinia Virus Deleted in Two Genes Involved in Nucleotide Metabolism

Molecular Therapy: Oncolytics, 2019
Oncolytic vaccinia viruses are currently in clinical development. However, the safety and the tumor selectivity of these oncolytic viruses must be improved.
Johann Foloppe, Juliette Kempf, Nicolas Futin, Jacqueline Kintz, Pascale Cordier, Christelle Pichon, Annie Findeli, Fabien Vorburger, Eric Quemeneur, Philippe Erbs   +9 more
doaj   +1 more source

Cyclosporine augments hepatic regenerative response in rats [PDF]

, 1990
A number of mechanisms participate in the hepatic injury that occurs during and following liver transplantation. A normal allograft regenerative response is probably essential for a successful transplant outcome. In this study, the effect of cyclosporine,
Dindzans, V, Eagon, PK, Kahn, D, Lai, H, Makowka, L, Starzl, TE, Van Thiel, DH   +6 more
core   +1 more source

Studies on the hyperplasia ('regeneration') of the rat liver following partial hepatectomy. Changes in lipid peroxidation and general biochemical aspects [PDF]

, 1990
Using the experimental model of partial hepatectomy in the rat, we have examined the relationship between cell division and lipid peroxidation activity. In rats entrained to a regime of 12 h light/12 h dark and with a fixed 8 h feeding period in the dark
Benedetto, C, Burton, GW, Cheeseman, KH, Collins, MW, Emery, S, Ingold, KU, Maddix, SP, Nodes, JT, Proudfoot, K, Slater, TF   +9 more
core   +2 more sources

Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins [PDF]

, 2014
The invasion of Theileria sporozoites into bovine leukocytes is rapidly followed by the destruction of the surrounding host cell membrane, allowing the parasite to establish its niche within the host cell cytoplasm.
Dobbelaere, D A, Heussler, V T, Von Schubert, C, Wastling, J M, Wiens, O, Woods, K L, Xia, D   +6 more
core   +6 more sources

Effect of cyclosporine on hepatic cytosolic estrogen and androgen receptor levels before and after partial hepatectomy [PDF]

, 1990
Estrogen and androgen receptors within the liver have been reported to modulate the hepatic regenerative response to partial hepatectomy. Moreover, cyclosporine has several untoward effects that might occur as a consequence of alterations in sex hormone ...
A Francavilla, A Francavilla, A. Francavilla, AK Roy, AM Hoyumpa, B Fisher, BA Stoll, CW Bardin, D Kahn, D. H. Van Thiel, D. Kahn, DH Thiel Van, F Kern Jr, G Klatskin, GC Chamness, GM Higgins, H. Lai, I Kam, J. S. Gavaler, JA Gustafsson, JA McGowan, JK Baum, L. Makowka, LE Porter, LJ Bennion, M Salizzori, OH Lowry, P. K. Eagon, PK Eagon, PK Eagon, RY Calne, SB Cardon, T. E. Starzl, TE Starzl   +33 more
core   +1 more source

Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes [PDF]

, 2007
In the present study, we have investigated the effect of the chemical CDK-inhibitor CYC202 on E6 and E7-transformed keratinocytes, in which the function of the cellular cell cycle inhibitor p21Cip1 is abrogated by the viral genes.
Atanasova, Ganka, Isaeva, Antonia R., Mitev, Vanyo I., Poumay, Yves, Zhelev, Nikolai   +4 more
core   +2 more sources

Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders

BMC Neuroscience, 2022
Background Deoxythymidine triphosphate (dTTP) is an essential building block of DNA, and defects in enzymes involved in dTTP synthesis cause neurodegenerative disorders.
Junmei Hu Frisk, Stefan Örn, Gunnar Pejler, Staffan Eriksson, Liya Wang   +4 more
doaj   +1 more source

Tunneling nanotubes: an alternate route for propagation of the bystander effect following oncolytic viral infection

Molecular Therapy: Oncolytics, 2016
Tunneling nanotubes (TNTs) are ultrafine, filamentous actin-based cytoplasmic extensions which form spontaneously to connect cells at short and long-range distances.
Justin Ady, Venugopal Thayanithy, Kelly Mojica, Phillip Wong, Joshua Carson, Prassanna Rao, Yuman Fong, Emil Lou   +7 more
doaj   +1 more source

The diagnostic value of serum microRNA-183 and TK1 as biomarkers for colorectal cancer diagnosis

Open Life Sciences, 2017
To evaluate the serum levels of microRNA-183 (miR-183) and thymidine kinase 1 (TK1) in colorectal cancer patients and their clinical value as biomarkers for colorectal cancer auxiliary diagnosis.
Zhu Xiangrong, Wang Xiongtie, Chen Xihua
doaj   +1 more source

Serum Thymidine Kinase (TK) Evaluation in HIV Infection

The International Journal of Biological Markers, 1989
Serum thymidine kinase (TK), measured using Prolifigen TK-REA, from AB Sangtec Medical, was investigated in 24 HIV seropositive patients without immunological alterations, 26 seropositives with immunological alterations, 125 LAS, 25 ARC, and 20 AIDS ...
S. Sabbatani, A. Fini, E. Raise, F.M. Gritti   +3 more
doaj   +1 more source