Results 21 to 30 of about 946,060 (233)

The proliferation marker thymidine kinase 1 in clinical use.

Molecular and clinical oncology, 2013
Tumor-related biomarkers are used for the diagnosis, prognosis and monitoring of treatments and follow-up of cancer patients, although only a few are fully accepted for the detection of invisible/visible tumors in health screening.
Ji Zhou, E. He, S. Skog
semanticscholar   +1 more source

Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major. [PDF]

PLoS Neglected Tropical Diseases, 2015
Leishmania spp. is a protozoan parasite and the causative agent of leishmaniasis. Thymidine kinase (TK) catalyses the transfer of the γ-phosphate of ATP to 2'-deoxythymidine (dThd) forming thymidine monophosphate (dTMP). L.
Jennifer Timm, Cristina Bosch-Navarrete, Eliseo Recio, Joanne E Nettleship, Heather Rada, Dolores González-Pacanowska, Keith S Wilson   +6 more
doaj   +1 more source

The diagnostic value of serum microRNA-183 and TK1 as biomarkers for colorectal cancer diagnosis

Open Life Sciences, 2017
To evaluate the serum levels of microRNA-183 (miR-183) and thymidine kinase 1 (TK1) in colorectal cancer patients and their clinical value as biomarkers for colorectal cancer auxiliary diagnosis.
Zhu Xiangrong, Wang Xiongtie, Chen Xihua
doaj   +1 more source

Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions

Cardiovascular Diabetology, 2007
Background Inhibition of vascular smooth muscle cell (vSMC) proliferation by oral anti-hyperglycemic agents may have a role to play in the amelioration of vascular disease in diabetes.
de Dios Stephanie T, Osman Narin, Little Peter J, Cemerlang Nelly, Ballinger Mandy, Nigro Julie   +5 more
doaj   +1 more source

Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy.

Molecular Therapy, 2013
Failure of clinical trials of nonviral vector-mediated gene therapy arises primarily from either an insufficient transgene expression level or immunostimulation concerns caused by the genetic information carrier (e.g., bacteria-generated, double-stranded
Yuhua Wang, Hsing-Hao Su, Yang Yang, Yunxia Hu, Lu Zhang, P. Blancafort, Leaf Huang   +6 more
semanticscholar   +1 more source

Thymidine kinase 2 mutations in autosomal recessive progressive external ophthalmoplegia with multiple mitochondrial DNA deletions.

Human Molecular Genetics, 2012
Autosomal-inherited progressive external ophthalmoplegia (PEO) is an adult-onset disease characterized by the accumulation of multiple mitochondrial DNA (mtDNA) deletions in post-mitotic tissues.
H. Tyynismaa, R. Sun, Sofia Ahola-Erkkilä, H. Almusa, R. Pöyhönen, Mari Korpela, J. Honkaniemi, P. Isohanni, A. Paetau, Liya Wang, A. Suomalainen   +10 more
semanticscholar   +1 more source

Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation

Journal of Oncology, 2012
Prognostic markers play an important role in our understanding of tumors and how to treat them. Thymidine kinase 1 (TK1), a proliferation marker involved in DNA repair, has been shown to have independent prognostic potential.
M. Alegre, R. Robison, K. O’Neill
semanticscholar   +1 more source

Thymidine Kinase 1: A Universal Marker for Cancer

, 2013
Thymidine Kinase 1 (TK1) is traditionally a serum biomarker which is elevated in the early stages of malignancies. TK1 is a DNA repair enzyme which is typically associated with proliferation. In serum, TK1 is elevated in a stage-like manner and increases
M. Alegre, R. Robison, K. O’Neill
semanticscholar   +1 more source

Limits of [18F]-FLT PET as a biomarker of proliferation in oncology. [PDF]

PLoS ONE, 2013
Non-invasive imaging biomarkers of cellular proliferation hold great promise for quantifying response to personalized medicine in oncology. An emerging approach to assess tumor proliferation utilizes the positron emission tomography (PET) tracer 3'-deoxy-
Eliot T McKinley, Gregory D Ayers, R Adam Smith, Samir A Saleh, Ping Zhao, Mary Kay Washington, Robert J Coffey, H Charles Manning   +7 more
doaj   +1 more source

Analysis of Genotype and Phylogenetic of Koi Herpesvirus (KHV) on Carp (Cyprinus carpio) in Lombok Island of West Nusa Tenggara Province Based on Thymidine Kinase Sequence

Journal of Experimental Life Science, 2018
Koi herpesvirus (KHV) is a virus that usually infects carp and koi causing mass mortality, as well as economic and social loss. The results of varied test are often found in its development.
Amira Baihani, Uun Yanuhar, Maftuch Maftuch   +2 more
doaj   +1 more source