Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes [PDF]
eLifeThe discovery of genetic alterations in patient samples over the last decades has reinforced a cell-autonomous view of proliferative expansion during T-cell acute lymphoblastic leukemia (T-ALL) development in the thymus.
Erika Tsingos +2 more
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A quantitative study of the mechanisms behind thymic atrophy in Gαi2-deficient mice during colitis development. [PDF]
PLoS ONE, 2012 Mice deficient for the G protein subunit Gαi2 spontaneously develop colitis, a chronic inflammatory disease associated with dysregulated T cell responses.
Kristina Elgbratt +2 more
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Interleukin-21 accelerates thymic recovery from glucocorticoïd-induced atrophy. [PDF]
PLoS ONE, 2013 Both physiological and psychological stress cause thymic atrophy via glucocorticoïd (GC)-dependent apoptosis of double-positive (DP) thymocytes. Given the pervasiveness of stress, GC-induced thymic atrophy is arguably the most common type of acquired ...
Moutih Rafei +3 more
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Scientific Reports, 2023 Phenotypic markers that denote different developmental stages of thymocytes are important for understanding T cell development in the thymus. Here, we show that CD1b is a critical discriminator of thymocyte maturation stage in cynomolgus monkeys.
Sung Min Choi +4 more
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Critical role of WNK1 in MYC-dependent early mouse thymocyte development
eLife, 2020 WNK1, a kinase that controls kidney salt homeostasis, also regulates adhesion and migration in CD4+ T cells. Wnk1 is highly expressed in thymocytes, and since migration is important for thymocyte maturation, we investigated a role for WNK1 in mouse ...
Robert Köchl +9 more
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Frontiers in Immunology, 2020 Thymocyte differentiation is dependent on the availability and transport of metabolites in the thymus niche. As expression of metabolite transporters is a rate-limiting step in nutrient utilization, cell surface transporter levels generally reflect the ...
Alice Machado +15 more
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Selective reduction of post-selection CD8 thymocyte proliferation in IL-15Rα deficient mice. [PDF]
PLoS ONE, 2012 Peripheral CD8(+) T cells are defective in both IL-15 and IL-15Rα knock-out (KO) mice; however, whether IL-15/IL-15Rα deficiency has a similar effect on CD8 single-positive (SP) thymocytes remains unclear.
Kai-Ping N Chow +7 more
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Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages
eLife, 2022 Interactions of developing T cells with Aire+ medullary thymic epithelial cells expressing high levels of MHCII molecules (mTEChi) are critical for the induction of central tolerance in the thymus.
Noella Lopes +7 more
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Immature thymocyte antigen-1: a novel thymocyte marker discriminating pre- and post-selected thymocytes [PDF]
International Immunology, 1998 Previously, we described a mAb (1-23) reacting with a novel cell surface antigen expressed on thymocytes at late CD4-CD8- [(double negative (DN)] to early CD4+CD8+ [(double positive (DP)] differentiation stage. Since the expression of this molecule was restricted to immature thymocytes, we designated it as immature thymocyte antigen-1 (IMT-1).
H, Kishi +3 more
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Development of double-positive thymocytes at single-cell resolution
Genome Medicine, 2021 Background T cells generated from thymopoiesis are essential for the immune system, and recent single-cell studies have contributed to our understanding of the development of thymocytes at the genetic and epigenetic levels.
Young Li +9 more
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