Results 31 to 40 of about 32,913 (197)
Metabolic regulation of T cell development
Frontiers in Immunology, 2022 T cell development in the thymus is tightly controlled by complex regulatory mechanisms at multiple checkpoints. Currently, many studies have focused on the transcriptional and posttranslational control of the intrathymic journey of T-cell precursors ...
Mengdi Zhang +7 more
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Neurotransmitters Modulate Intrathymic T-cell Development
Frontiers in Cell and Developmental Biology, 2021 The existence of a crosstalk between the nervous and immune systems is well established. Neurotransmitters can be produced by immune cells, whereas cytokines can be secreted by cells of nervous tissues.
Carolina Francelin +14 more
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Aldehydes participation in oxidative stress in rat thymocytes in vitro [PDF]
The Ukrainian Biochemical Journal, 2014 A variety of lipid radicals are formed under oxidative stress development. The further oxidation of these radicals leads to formation of numerous aldehydes.
K. О. Tokarchuk, О. V. Zaitseva
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Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection
eLife, 2021 Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–double negative (DN) thymocytes to generate αβ T cells in the thymus.
Xia Liu +13 more
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Thymosin Beta 15 Alters the Spatial Development of Thymic Epithelial Cells
Cells, 2022 The thymus is the most sensitive organ under various pathophysiological conditions, such as aging, starvation, and infection. As a key stromal cell for T cell development, it is well-known that thymic epithelial cells (TECs) play an important role in the
Xie Xu +11 more
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The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ. [PDF]
Immunol RevABSTRACT The thymus is emerging as a model for studying organ regeneration and stem cell biology. While research has long focused on how antigen‐presenting cells shape the T cell repertoire, recent discoveries unveil a far richer cellular landscape that challenges long‐held views of thymus structure and function. This review traces the history of early
Ragazzini R, Bonfanti P.
europepmc +2 more sources
CD47 Promotes, While Exposure to Apoptotic Cells Destroys the Fusion Program of Differentiating Myoblasts. [PDF]
FASEB J(A) CD47, acting in a cis‐manner with integrins, promotes myoblast fusion. TSP‐1 serves as a bridging molecule for these proteins to recognize PS on the surface of the other fusing myoblasts. (B) Blocking of these signals by neutralizing antibodies reduces cell fusion. Inhibition of PIEZO1 activity by constantly expressed PS on apoptotic cells leads to
Ali MA +10 more
europepmc +2 more sources
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
The thymus and T-cell ontogeny in ballan wrasse (Labrus bergylta) is nutritionally modelled
Frontiers in Immunology, 2023 Marine fish larvae often experience high mortality unrelated to predation during early life stages, and farmed ballan wrasse (Labrus bergylta) is no exception.
Angela Etayo +6 more
doaj +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source