Results 41 to 50 of about 32,913 (197)
Impact of in vitro HIV infection on human thymic regulatory T cell differentiation
Frontiers in Microbiology, 2023 BackgroundThe differentiation and function of immunosuppressive regulatory T cells (Tregs) is dictated by the master transcription factor FoxP3. During HIV infection, there is an increase in Treg frequencies in the peripheral blood and lymphoid tissues ...
Sharada Swaminathan +7 more
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T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Is the thymus a target organ in infectious diseases?
Memorias do Instituto Oswaldo Cruz, 1992 The thymus is a central lymphoid organ, in wich T cell precursors differentiale and generate most of the so-called T cell reprtoire. Along with a variety of acute infectious diseases, we and others determined important changes in both microenvironmental ...
Wilson Savino +5 more
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Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity
Advanced Science, EarlyView.This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou +8 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2020 The death receptor Fas can induce cell death through the extrinsic pathway of apoptosis in a variety of cells, including developing thymocytes. Although Fas-induced cell death has been researched and modeled extensively, most of the studies have been ...
Chang-Feng Chu +4 more
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Arthritis &Rheumatology, Accepted Article.Objective High intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced SSc. The role of reduced intensity conditioning (RIC) prior to AHSCT in this population remains unclear. We conducted this study to determine the long‐term outcomes of RIC AHSCT in SSc patients with cardiac ...
Yonatan Lean +4 more
wiley +1 more source
Frontiers in Endocrinology, 2018 T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease.
Ana Rosa Pérez +8 more
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Mature T‐cell leukemia/lymphoma with an NK‐like immunophenotype: A report of 7 cases
Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Distinguishing T‐cell from NK‐cell neoplasms can occasionally be challenging, as neoplastic T cells can lose T‐cell markers such as surface CD3 (sCD3) and CD5 while acquiring NK‐cell markers such as CD16, CD56, and CD94. In this study, we present a series of 7 mature T‐cell lymphoma/leukemia cases with NK‐like immunophenotypes to clarify ...
Wei J. Wang +8 more
wiley +1 more source
T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development. [PDF]
PLoS ONE, 2014 Natural killer T (NKT) cells are a component of innate and adaptive immune systems implicated in immune, autoimmune responses and in the control of obesity and cancer.
Archna Sharma +2 more
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Cytometry Part B: Clinical Cytometry, EarlyView.Abstract The objective of this 12‐color/13‐antibody single‐tube panel is to assist in the diagnosis of T/NK‐cell leukemias and lymphomas. In the clinical setting, the absence of a standardized T/NK‐cell panel limits inter‐laboratory data comparability, contributes to diagnostic variability, and results in redundant efforts across laboratories to design
Nicole So +5 more
wiley +1 more source