Results 71 to 80 of about 32,913 (197)
The NF‐κB transcription factor RelA directs mucosal‐associated invariant T‐cell development
Immunology &Cell Biology, EarlyView.In this study, we found that the nuclear factor kappa light chain enhancer in activated B cells (NF‐κB) transcription factor RelA, and to a lesser extent NF‐κB1 and NF‐κB2, are key regulators of mucosal‐associated invariant T (MAIT)‐cell development and differentiation.
Thomas S Fulford +15 more
wiley +1 more source
Autoimmunity and Periodontitis
Journal of Periodontal Research, EarlyView.In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga +2 more
wiley +1 more source
Transplant Infectious Disease, EarlyView.This study reveals that infections are highly prevalent in pediatric IEI patients after umbilical cord blood transplantation, with early‐stage infections and bloodstream infections strongly associated with poorer survival. These findings advocate for risk‐stratified surveillance and preemptive strategies in high‐risk subgroups.
Zhongling Wei +8 more
wiley +1 more source
SATB1-mediated chromatin landscape in T cells
Nucleus, 2020 The regulatory circuits that define developmental decisions of thymocytes are still incompletely resolved. SATB1 protein is predominantly expressed at the CD4+CD8+cell stage exerting its broad transcription regulation potential with both activatory and ...
Tomas Zelenka, Charalampos Spilianakis
doaj +1 more source
Comparative 3‐Year Allograft Outcomes for Recipients of Kidneys From SARS‐CoV‐2 NAT‐Positive Donors
Transplant Infectious Disease, EarlyView.In this retrospective single‐center study of 220 kidney transplants from SARS‐CoV‐2 NAT+, NAT+ with COVID as cause of death (CoV‐COD) and NATneg donors, we found no significant difference in rejection or kidney pathologies at 1 year, and death, graft loss, or eGFR at 3 years by CoV‐donor status.
Christine E. Koval +5 more
wiley +1 more source
Clinical implications of imlifidase interference in antibody screening and transfusion management
Transfusion, EarlyView.Abstract Background Imlifidase has received conditional approval from the EMA for desensitizing deceased donor kidney transplant recipients. It works by cleaving IgG into F(ab′)2 and Fc fragments, thereby reducing the risk of antibody‐mediated rejection. However, its impact on diagnostic assays remains understudied. Case Report We present the case of a
Zgjim Osmani +2 more
wiley +1 more source
Patologìâ, 2017 In medicine narcotic analgesics have long been used for therapeutic purposes, but their influence on the organs of the immune system is insufficiently studied.
T. V. Harapko , A. S. Holovatskyi
doaj +1 more source
Serological screening for cytomegalovirus in a leucodepleted blood supply: A systematic review
Vox Sanguinis, EarlyView.Abstract Background and Objectives Cytomegalovirus (CMV) causes harm in at‐risk populations. Selection of seronegative donors has been used to prevent transmission. Leucodepletion reduces the potential for CMV transmission; however, the residual risk is uncertain, leading to variability in practice.
Philip J. Crispin +7 more
wiley +1 more source
eJHaem, Volume 7, Issue 2, April 2026.ABSTRACT Background Immunosuppressive therapy (IST) is standard first‐line treatment for severe aplastic anaemia (AA) in patients ineligible for allogeneic transplantation. Thrombopoietin receptor agonists (TPO‐RAs) are increasingly added to IST to improve haematologic recovery, but long‐term safety remains uncertain.
Elham Ashrafi +5 more
wiley +1 more source