Results 91 to 100 of about 2,990,232 (287)

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Clinical Characteristics and Genotype-phenotype Correlation in Turkish Patients with a Diagnosis of Resistance to Thyroid Hormone Beta [PDF]

Objective: Resistance to thyroid hormone beta (RTHβ) is a rare disorder characterized by a fairly heterogeneous clinical presentation due to varying degrees of tissue response to thyroid hormone.
Çavdarlı, Büşranur, Mehmet Boyraz, Boyraz, Mehmet, Büşranur Çavdarlı, Nur Semerci Gündüz, cakal, erman, Oya Topaloğlu, Gündüz, C.Nur Semerci, Sema Hepşen, Demirbilek, Huseyin, Erman Çakal, gürbüz, fatih, Aydın, Cevdet, Koca, Serkan bilge, Keziban Toksoy Adıgüzel, topaloglu, oya, Cevdet Aydın, Fatih Gürbüz, Hüseyin Demirbilek, Serkan Bilge Koca, HEPŞEN, SEMA, Toksoy, Keziban, Buyukyilmaz, Gonul, Gönül Büyükyılmaz, Semerci Gündüz, Nur, Büyükyılmaz, GÖNÜL, Toksoy Adıgüzel, Keziban   +26 more
core   +1 more source

Potential of Seaweed to Improve the Quality and Shelf Life of Fish and Fishery Products

Food Safety and Health, EarlyView.
Growing global demand for safe fish preservation has increased interest in natural alternatives. Seaweed‐derived bioactive compounds possess antioxidant and antimicrobial properties that enhance fish quality, safety, and shelf life. These sustainable preservatives may reduce spoilage and synthetic preservative use, though further research ...
Ashika Banu Rodela, Md. Golam Rasul, Ilias Ebne Kabir, Jahid Hasan, Chunhong Yuan, Bhaskar Chandra Majumdar   +5 more
wiley   +1 more source

Impaired sensitivity to thyroid hormones is associated with all-cause and cause-specific mortality among chronic kidney disease patients: results from National Health and Nutrition Examination Survey (NHANES) 2007–2012

Renal Failure
Background Resistance to thyroid hormone shows underlying mechanical link with chronic kidney disease (CKD) and is prevalent in CKD population. However, whether it attributes to mortality risk among CKD population is unknown.
Chan Liu, Xiaoxiao Zhu, Dingding Wang, Naya Huang, Wei Chen   +4 more
doaj   +1 more source

Prematurity is associated with altered central thyroid hormone sensitivity

Frontiers in Endocrinology
ObjectivesThyroid Feedback Quantile-based Index (TFQI), the Thyrotropin–Thyroxine Resistance Index (TT4RI), and the Thyrotropin Index (TSHI) have been developed to assess central sensitivity to thyroid hormones by integrating circulating thyroid hormone ...
Gülçin Arslan, Hakan Birinci, Şükrü Onur Halaç, Eren Er, Aslıhan Abbasoğlu, Bumin Nuri Dündar   +5 more
doaj   +1 more source

Impact of Single‐Cell RNA Reference Selection for the Deconvolution of Breast Cancer Spatial Transcriptomics Datasets

International Journal of Cancer, EarlyView.
ABSTRACT Spot‐based spatial transcriptomics (ST) allows for unbiased gene expression analysis within tissue architecture, overcoming the limitations of single‐cell RNA sequencing (scRNA‐seq) by preserving spatial context. However, the high spatial resolution in ST leads to cellular heterogeneity within spots, requiring computational deconvolution to ...
Stefan Altendorfer, Scott J. Walker, Carsten O. Daub   +2 more
wiley   +1 more source

Sensitivity to thyroid hormones in Egyptian euthyroid patients with metabolic syndrome

The Egyptian Journal of Internal Medicine
Background Metabolic syndrome (MetS) is a common metabolic and endocrine disease, and many studies have found that thyroid disorders, both overt and subclinical, might be accompanied by the risk of MetS. Objectives Assessment of indices of sensitivity to
Heba Ibrahim Selim, Fayez Elkenawy Mohammad, Mohammed Ibrahim Abd El-Ghany   +2 more
doaj   +1 more source

Reduced sensitivity to thyroid hormones is associated with differentiated thyroid cancer in the euthyroid thyroidectomy population

Frontiers in Endocrinology
BackgroundThe inconclusive associations between thyroid-related hormones and differentiated thyroid cancer (DTC) suggest complex pathophysiologic processes, for which thyroid hormone sensitivity may provide new insights.MethodsWe retrospectively analyzed
Huaijin Xu, Huaijin Xu, Hongzhou Liu, Xiaodong Hu, Xiaomeng Jia, Zhe Xue, Anning Wang, Shaoyang Kang, Shaoyang Kang, Zhaohui Lyu, Zhaohui Lyu   +10 more
doaj   +1 more source

Homozygous Thyroid Hormone Receptor beta-Gene Mutations in Resistance to Thyroid Hormone: Three New Cases and Review of the Literature

, 2012
Context: The most common cause of resistance to thyroid hormone (RTH) is heterozygous thyroid hormonereceptor beta(THRB) gene mutations.
Ferrara, Alfonso Massimiliano, Onigata, Kazumichi, WEISS, Roy E, Ercan, Oya, MASSIMILIANO FERRARA, Alfonso, Weiss, Roy E., Woodhead, Helen, Refetoff, Samuel   +7 more
core   +1 more source

The effect of ovarian stimulation protocol on follicular asynchrony during in vitro fertilization – A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To examine the effect of controlled ovarian stimulation (COS) protocol on follicular synchrony in a subsequent in vitro fertilization (IVF) cycle in patients whose previous cycle was canceled due to asynchrony. Methods A single‐center retrospective‐cohort study (January 2018–March 2024), including women undergoing IVF who had: (1) a ...
Alyssa Hochberg, Maria Hincapie, Uri Amikam, Nir Kugelman, William Buckett, Shauna Reinblatt   +5 more
wiley   +1 more source