Results 1 to 10 of about 21,588 (98)

Effect of sub-inhibitory tigecycline (½-MIC) on AcrAB-TolC and mar/ram/sox regulatory genes in Enterobacter cloacae complex isolates [PDF]

Frontiers in Cellular and Infection Microbiology
The global rise of antimicrobial resistance (AMR) in Enterobacterales, including the Enterobacter cloacae complex, is narrowing treatment options.
Lukasz Korczak, Piotr Majewski, Pawel Sacha, Dominika Chludzinska, Elzbieta Tryniszewska   +4 more
doaj   +2 more sources

Heteroresistance is associated with mutations during low concentration of tigecycline therapy in multiple-resistant Klebsiella pneumoniae [PDF]

Annals of Clinical Microbiology and Antimicrobials
Background Heteroresistance can lead to treatment failure and has brought a rigorous challenge to clinical laboratories for detecting them. The aim of this study was to investigate the potential for tigecycline-susceptible Klebsiella pneumoniae (K ...
Qiaoyu Zhang, Linwen Zheng, Lirong Wen, Shanshan Li, Yuli Nie, Jiansen Chen   +5 more
doaj   +2 more sources

Fitness Costs of Tigecycline Resistance in Acinetobacter baumannii and the Resistance Mechanism Revealed by a Transposon Mutation Library

Antibiotics, 2022
Acinetobacter baumannii is one of the main pathogens causing nosocomial and community-acquired infections. Tigecycline is an important antibiotic for the treatment of multidrug-resistant A.
Ping Wang, Hongou Wang, Cunwei Liu, Chengjie Feng, Qinghui Lu, Qinghua Zou   +5 more
doaj   +1 more source

Tigecycline Heteroresistance and Resistance Mechanism in Clinical Isolates of Acinetobacter baumannii

Microbiology Spectrum, 2021
Tigecycline is regarded as a last-resort treatment for multidrug-resistant Acinetobacter baumannii. However, tigecycline resistance in A. baumannii has increased worldwide. In this study, we investigated tigecycline heteroresistance in A.
Jeongwoo Jo, Kwan Soo Ko
doaj   +1 more source

Comparison of bleeding risk and hypofibrinogenemia-associated risk factors between tigecycline with cefoperazone/sulbactam therapy and other tigecycline-based combination therapies

Frontiers in Pharmacology, 2023
Background: Tigecycline and cefoperazone/sulbactam can cause coagulation disorders; tigecycline may also lead to hypofibrinogenemia, raising safety concerns.
Lei Zhang, Xinfeng Cai, Fangchen Peng, Shuangshuang Tian, Xinjing Wu, Yun Li, Jinlin Guo   +6 more
doaj   +1 more source

Reduced virulence in tigecycline-resistant Klebsiella pneumoniae caused by overexpression of ompR and down-regulation of ompK35

Journal of Biomedical Science, 2023
Background The development of tigecycline resistance in hypervirulent Klebsiella pneumoniae strains has resulted in decreased virulence that is associated with reduced production of capsular polysaccharides (CPS).
Suyeon Park, Hyunkeun Kim, Kwan Soo Ko
doaj   +1 more source

Genomic and Phenotypic Evolution of Tigecycline-Resistant Acinetobacter baumannii in Critically Ill Patients

Microbiology Spectrum, 2022
Acinetobacter baumannii is an important opportunistic pathogen of nosocomial infections. A. baumannii presently exhibits increasing antibiotic resistance, which poses great challenges to public health. The occurrence of tigecycline-resistant A. baumannii
Jiangang Zhang, Jinru Xie, Henan Li, Zhiren Wang, Yuyao Yin, Shuyi Wang, Hongbin Chen, Qi Wang, Hui Wang   +8 more
doaj   +1 more source

Tigecycline Resistance-Associated Mutations in the MepA Efflux Pump in Staphylococcus aureus

Microbiology Spectrum, 2023
Tigecycline is an important antibacterial drug for treating infection by clinical multidrug-resistant bacteria, and tigecycline-resistant Staphylococcus aureus (TRSA) has been increasingly reported in recent years.
Honghao Huang, Peng Wan, Xinyue Luo, Yixing Lu, Xiaoshen Li, Wenguang Xiong, Zhenling Zeng   +6 more
doaj   +1 more source

Proteomics Study of the Synergistic Killing of Tigecycline in Combination With Aminoglycosides Against Carbapenem-Resistant Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology, 2022
Co-administration of antibiotics with synergistic effects is one method to combat carbapenem-resistant organisms. Although the synergistic effects of tigecycline combined with aminoglycosides against carbapenem-resistant Klebsiella pneumoniae (CRKP) have
Xinqian Ma, Shining Fu, Yifan Wang, Lili Zhao, Wenyi Yu, Yukun He, Wentao Ni, Zhancheng Gao   +7 more
doaj   +1 more source

Novel tigecycline resistance mechanisms in Acinetobacter baumannii mediated by mutations in adeS, rpoB and rrf

Emerging Microbes and Infections, 2021
Acinetobacter baumannii is an important pathogen in hospital acquired infections. Although tigecycline currently remains a potent antibiotic for treating infections caused by multidrug resistant A.
Xiaoting Hua, Jintao He, Jingfen Wang, Linghong Zhang, Linyue Zhang, Qingye Xu, Keren Shi, Sebastian Leptihn, Yue Shi, Xiaoting Fu, Pengfei Zhu, Paul G. Higgins, Yunsong Yu   +12 more
doaj   +1 more source