Results 11 to 20 of about 21,607 (116)

Emergence of Tigecycline-Resistant Pseudomonas aeruginosa Harbouring tmexC6D6-toprJ1b From Hospital Sewage in Japan. [PDF]

Environ Microbiol Rep
This study isolated a Pseudomonas aeruginosa strain (KAM950) carrying the tmexCD‐toprJ gene cluster from hospital sewage in Japan. The strain exhibited reduced susceptibility to tigecycline and carbapenems, harboured chromosomal tmexC6D6‐toprJ1b and oprD disruption, and belonged to epidemic clone ST244, emphasising emerging multidrug resistance and the
Maehana S, Suzuki M, Ishimura N, Izawa H, Eda R, Nakamura M, Amarasiri M, Furukawa T, Kojima F, Sei K, Kubo M.   +10 more
europepmc   +2 more sources

A Novel Tigecycline Adjuvant ML-7 Reverses the Susceptibility of Tigecycline-Resistant Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology, 2022
The increasing incidence of tigecycline resistance undoubtedly constitutes a serious threat to global public health. The combination therapies had become the indispensable strategy against this threat. Herein, 11 clinical tigecycline-resistant Klebsiella
Lilan Sun, Lang Sun, Xue Li, Xinxin Hu, Xiukun Wang, Tongying Nie, Youwen Zhang, Xuefu You   +7 more
doaj   +1 more source

In-vitro activity of tigecycline and comparator agents against common pathogens: Indian experience

Journal of Infection in Developing Countries, 2019
Introduction: Tigecycline Evaluation and Surveillance Trail (TEST) study is an on-going global surveillance. The study was performed to determine the susceptibility of common pathogens to tigecycline and comparator antibiotics by broth microdilution ...
Balaji Veeraraghavan, Aruna Poojary, Chaitra Shankar, Anurag Kumar Bari, Seema Kukreja, Bhuvaneswari Thukkaram, Ramya Gajaraj Neethimohan, Yamuna Devi Bakhtavachalam, Shweta Kamat   +8 more
doaj   +1 more source

Five-Years Tigecycline Experience an Analysis of Real-Life Data

Haseki Tıp Bülteni, 2018
Aim: Tigecycline has been approved by the Food and Drug Administration for the treatment of complicated intra-abdominal infections, skin and soft tissue infections and community-acquired pneumonia.
Fatih Temocin, Necla Eren Tülek, Şirin Hekimoğlu, Tuba Ilgar, Cemal Bulut, Fatma Şebnem Erdinç, Günay Tuncer Ertem, Çiğdem Ataman Hatipoğlu, Sami Kınıklı   +8 more
doaj   +1 more source

Effect of ramR loss-of-function insertion on tigecycline resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae

Journal of Global Antimicrobial Resistance, 2020
Objectives: Tigecycline is an antibacterial agent restricted for use against carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to identify the tigecycline resistance mechanism in clinical CRKP isolates obtained from a 60-year-old ...
Yihan Mao, Qiucheng Shi, Ping Zhang, Yan Jiang, Yunsong Yu   +4 more
doaj   +1 more source

Prevalence and risk factors of tigecycline-induced liver injury: A multicenter retrospective study

International Journal of Infectious Diseases, 2022
: Objective: We conducted this multicenter retrospective study to evaluate the prevalence, clinical patterns, and risk factors for tigecycline-induced liver injury, which is a type of drug-induced liver injury (DILI).
Zhenwei Yu, Yuhua Zhao, Jiayi Jin, Jianping Zhu, Lingyan Yu, Gang Han   +5 more
doaj   +1 more source

Induction of Tigecycline Resistance in Acinetobacter baumannii

Bio-Protocol, 2014
Multidrug resistance Acinetobacter baumannii (A. baumannii) (MDRAB) has emerged as a serious threat in hospitals in recent years. Currently, there are few antibiotics, including tigecycline, available to treat infections caused by MDRAB effectively. Both
Ming-Feng Lin, Yun-You Lin, Chung-Yu Lan
doaj   +1 more source

Characterization of Tigecycline-Heteroresistant Klebsiella pneumoniae Clinical Isolates From a Chinese Tertiary Care Teaching Hospital

Frontiers in Microbiology, 2021
Tigecycline has been used as one of the therapeutic choices for the treatment of infections caused by multidrug-resistant Klebsiella pneumoniae. However, the emergence of tigecycline heteroresistance has led to great challenges in treating these ...
Qiaoyu Zhang, Liping Lin, Yuhong Pan, Jiansen Chen   +3 more
doaj   +1 more source

Tigecycline Interferes with Fibrinogen Polymerization Independent of Peripheral Interactions with the Coagulation System

Antibiotics, 2020
Tigecycline offers broad anti-bacterial coverage for critically ill patients with complicated infections. A described but less researched side effect is coagulopathy.
Anna Brandtner, Mirjam Bachler, Dietmar Fries, Martin Hermann, Jacqueline Ruehlicke, Vilmos Fux, Andrea Griesmacher, Christian Niederwanger, Tobias Hell, Benedikt Treml   +9 more
doaj   +1 more source

In vitro and in vivo antibacterial activity of tigecycline against Vibrio vulnificus

Journal of Microbiology, Immunology and Infection, 2018
Background/purpose: The aim of this study is to investigate the role of tigecycline in Vibrio vulnificus infection. Methods: Eight randomly selected clinical V.
Hung-Jen Tang, Chi-Chung Chen, Chih-Cheng Lai, Chun-Cheng Zhang, Tzu-Chieh Weng, Yu-Hsin Chiu, Han-Siong Toh, Shyh-Ren Chiang, Wen-Liang Yu, Wen-Chien Ko, Yin-Ching Chuang   +10 more
doaj   +1 more source