Results 31 to 40 of about 21,607 (116)

Tigecycline causes loss of cell viability mediated by mitochondrial OXPHOS and RAC1 in hepatocellular carcinoma cells

Journal of Translational Medicine, 2023
Background Despite recent advances in locoregional, systemic, and novel checkpoint inhibitor treatment, hepatocellular carcinoma (HCC) is still associated with poor prognosis.
Dominik T. Koch, Haochen Yu, Iris Beirith, Malte Schirren, Moritz Drefs, Yunfei Liu, Mathilda Knoblauch, Dionysios Koliogiannis, Weiwei Sheng, Enrico N. De Toni, Alexandr V. Bazhin, Bernhard W. Renz, Markus O. Guba, Jens Werner, Matthias Ilmer   +14 more
doaj   +1 more source

Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance

mSystems, 2021
The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the ...
Chao-Yue Cui, Qian He, Qiu-Lin Jia, Cang Li, Chong Chen, Xiao-Ting Wu, Xiao-Jing Zhang, Zhuo-Yu Lin, Zi-Jian Zheng, Xiao-Ping Liao, Barry N. Kreiswirth, Ya-Hong Liu, Liang Chen, Jian Sun   +13 more
doaj   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

A novel mutation of ramR involved in tigecycline resistance in Klebsiella pneumoniae

Microbiology Spectrum
This study aims to investigate the novel potential tigecycline resistance mechanism in Klebsiella pneumoniae and provide new insights for the clinical treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae. In vitro experiments were
Yuyao Xu, Qi Chen, Chenhao Zhao, Xin Ma, Lei Wang, Feinan Qian, Xiangyu Guan, Hong Du, Haifang Zhang   +8 more
doaj   +1 more source

Multiple Mechanisms of Tigecycline Resistance in Enterobacteriaceae from a Pig Farm, China

Microbiology Spectrum, 2021
We isolated eight tigecycline-resistant Enterobacteriaceae strains from a pig farm in Shanghai, China, including Escherichia coli (n = 1), Proteus cibarius (n = 1), and Enterobacter hormaechei (n = 6). Two of them (E. coli and P.
Jing Wang, Han Wu, Cai-Yue Mei, Yan Wang, Zhen-Yu Wang, Meng-Jun Lu, Zhi-Ming Pan, Xinan Jiao   +7 more
doaj   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Clinical effectiveness of tigecycline in combination therapy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective multi-centre observational study

Journal of Intensive Care, 2023
Background Tigecycline has in vitro bacteriostatic activity against a broad spectrum of bacteria, including carbapenem-resistant Gram-negative bacteria (CR-GNB).
Kuang-Yao Yang, Chung-Kan Peng, Chau-Chyun Sheu, Yu-Chao Lin, Ming-Cheng Chan, Sheng-Huei Wang, Chia-Min Chen, Chih-Yu Chen, Zhe-Rong Zheng, Jia-Yih Feng, the T-CARE (Taiwan Critical Care and Infection) Group   +10 more
doaj   +1 more source

Acquisition of Tigecycline Resistance by Carbapenem-Resistant Klebsiella pneumoniae Confers Collateral Hypersensitivity to Aminoglycosides

Frontiers in Microbiology, 2021
Tigecycline is a last-resort antibiotic for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to broaden our understanding of the acquisition of collateral hypersensitivity by CRKP, as an evolutionary trade-off of ...
Hua-le Chen, Hua-le Chen, Yan Jiang, Mei-mei Li, Yao Sun, Jian-ming Cao, Cui Zhou, Xiao-xiao Zhang, Yue Qu, Tie-li Zhou   +9 more
doaj   +1 more source

A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae

Microbiology Spectrum
Whole-genome sequencing of a clinical tigecycline non-susceptible Klebsiella pneumoniae strain reveals a novel T188A mutation in AcrA, raising awareness on its role in tigecycline resistance.
Yingchao Xu, Wenjia Wang, Wenya Su, Mingyu Wang, Hai Xu, Xuhua Zhang, Ling Li   +6 more
doaj   +1 more source

Developmental dynamics of antibiotic resistome in aerobic biofilm microbiota treating wastewater under stepwise increasing tigecycline concentrations

Environment International, 2019
This study aimed to investigate the impact of tigecycline, the third generation tetracycline, on the antibiotic resistance development in environmental microbiota.
Zhe Tian, Ruyin Liu, Hong Zhang, Min Yang, Yu Zhang   +4 more
doaj   +1 more source