Results 51 to 60 of about 28,714 (188)

Systematic evaluation and Meta-analysis of the efficacy and safety of different doses of tigecycline in ventilator-associated pneumonia caused by multiple resistant bacteria

, 2023
Introduction Ventilator-associated pneumonia (VAP) caused by multi-resistant bacteria is a serious complication in hospitalized patients. Tigecycline, a broad-spectrum antibiotic, has been suggested as a potential treatment option for this condition, but
Junlin L u, Changwen Feng, Qingming Mo, Wendian Zhu, Xiaoshan Yang, Zhaoxu Cai, Junlin Lu   +6 more
core   +1 more source

Lon dysfunction-mediated collateral sensitivity drives effective antibiotic combination therapies against tigecycline-resistant pathogens

Cell Reports
Summary: Tigecycline is a last-resort antibiotic primarily used to treat severe infections caused by multidrug-resistant (MDR) bacteria. However, the emergence of constantly appearing resistance determinants has drastically compromised its clinical ...
Feiyu Yu, Shuyao Zhu, Qingyang Lv, Dan Fang, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
doaj   +1 more source

Combination of Lenvatinib and Antibiotics: A Potential Approach to Enhance Sensitivity in Differentiated Thyroid Cancer

International Journal of Cancer, Volume 159, Issue 8, Page 1974-1989, 15 October 2026.
Although lenvatinib is the current first‐line therapy for radioiodine‐refractory differentiated thyroid carcinoma, its use is limited by severe side effects and reduced sensitivity. Here, the authors assessed the potential of sensitizing differentiated thyroid carcinoma tumor cells with limited lenvatinib responsiveness through the administration of ...
Celina Ablinger, Petra Huber‐Cantonati, Daniela D. Weber, Sarah Pichler, Georg Schischkow, Marta Garcia‐Miralles, Christian Pirich, Gundula Rendl, Teresa Kiener, Thomas Felder, Martin Geroldinger, Robert Terkola, Barbara Kofler, Johanna Pachmayr   +13 more
wiley   +1 more source

A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae

Microbiology Spectrum
Whole-genome sequencing of a clinical tigecycline non-susceptible Klebsiella pneumoniae strain reveals a novel T188A mutation in AcrA, raising awareness on its role in tigecycline resistance.
Yingchao Xu, Wenjia Wang, Wenya Su, Mingyu Wang, Hai Xu, Xuhua Zhang, Ling Li   +6 more
doaj   +1 more source

Effect of Green‐Synthesized Silver Nanoparticles From Nepeta pogonosperma and Astrodaucus persicus on the Reduction of Bap Gene Expression in Strong Biofilm‐Producing Acinetobacter baumannii Clinical Isolates

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Green‐synthesized silver nanoparticles from Nepeta pogonosperma and Astrodaucus persicus significantly inhibit biofilm formation and downregulate bap gene expression in multidrug‐resistant clinical isolates of Acinetobacter baumannii. This eco‐friendly approach offers a promising strategy to combat antimicrobial resistance.
Maedeh Kakavan, Mehrdad Gholami, Mohammad Ahanjan, Mohammad Ali Ebrahimzadeh, Abolfazl Hossein Nataj, Tahoora Mousavi, Hamid Reza Goli   +6 more
wiley   +1 more source

A novel mutation of ramR involved in tigecycline resistance in Klebsiella pneumoniae

Microbiology Spectrum
This study aims to investigate the novel potential tigecycline resistance mechanism in Klebsiella pneumoniae and provide new insights for the clinical treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae. In vitro experiments were
Yuyao Xu, Qi Chen, Chenhao Zhao, Xin Ma, Lei Wang, Feinan Qian, Xiangyu Guan, Hong Du, Haifang Zhang   +8 more
doaj   +1 more source

Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance

mSystems, 2021
The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the ...
Chao-Yue Cui, Qian He, Qiu-Lin Jia, Cang Li, Chong Chen, Xiao-Ting Wu, Xiao-Jing Zhang, Zhuo-Yu Lin, Zi-Jian Zheng, Xiao-Ping Liao, Barry N. Kreiswirth, Ya-Hong Liu, Liang Chen, Jian Sun   +13 more
doaj   +1 more source

Adjuvant Antibacterial Effects of Mouriri Elliptica Against Clinical Multidrug Resistant Gram‐Negative Bacterial Strains

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The ethanolic leaf extract of Mouriri elliptica exhibited antibacterial and antibiofilm activities against multidrug‐resistant clinical isolates and enhanced the activity of ampicillin. Its diverse chemical profile and low acute toxicity support this Cerrado species as a promising source of natural antibacterial adjuvants. ABSTRACT Bacterial resistance
Talita Vilalva Freire, Ana Carolina de Freitas Marques, Valéria dos Santos Gonçalves, Iluska Senna Bonfá Moslaves, Mônica Cristina Toffoli‐Kadri, Arthur Feliciano Camargo da Silva, Martha Janete Giz, Patrícia de Oliveira Figueiredo, Ana Camila Micheletti, Nídia Cristiane Yoshida   +9 more
wiley   +1 more source

In vitro interference of tigecycline at subinhibitory concentrations on biofilm development by Enterococcus faecalis

, 2012
Objectives: Since biofilm formation is the hallmark of Enterococcus faecalis isolates, the aim of this study was to quantify biofilm formation in the presence of subinhibitory concentrations of tigecycline. Methods: Interference of tigecycline on biofilm
Giménez, María José, Alou Cervera, Luis, Maestre, Juan Ramón, Mendez, María Luisa, Granizo, Juan José, Prieto Prieto, José, Aguilar, Lorenzo, Mateo, María   +7 more
core   +1 more source

Developmental dynamics of antibiotic resistome in aerobic biofilm microbiota treating wastewater under stepwise increasing tigecycline concentrations

Environment International, 2019
This study aimed to investigate the impact of tigecycline, the third generation tetracycline, on the antibiotic resistance development in environmental microbiota.
Zhe Tian, Ruyin Liu, Hong Zhang, Min Yang, Yu Zhang   +4 more
doaj   +1 more source