Results 51 to 60 of about 26,995 (192)

Multiple Mechanisms of Tigecycline Resistance in Enterobacteriaceae from a Pig Farm, China

Microbiology Spectrum, 2021
We isolated eight tigecycline-resistant Enterobacteriaceae strains from a pig farm in Shanghai, China, including Escherichia coli (n = 1), Proteus cibarius (n = 1), and Enterobacter hormaechei (n = 6). Two of them (E. coli and P.
Jing Wang, Han Wu, Cai-Yue Mei, Yan Wang, Zhen-Yu Wang, Meng-Jun Lu, Zhi-Ming Pan, Xinan Jiao   +7 more
doaj   +1 more source

Aetiology and Antibiotic Susceptibility of Common Bacterial Infections in Hospitalised Patients: A 2019 Multisite Cross‐Sectional Survey in Jakarta, Indonesia

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objectives To describe the aetiology and antibiotic susceptibility patterns of common bacterial infections in hospitalised patients in Jakarta, Indonesia. Methods We conducted a hospital‐wide point prevalence survey in six hospitals in 2019, capturing data from routinely ordered bacterial cultures taken before the start of antibiotic treatment.
Justin de Brabander, Erni J. Nelwan, Ralalicia Limato, Monik Alamanda, Manzilina Mudia, Enty Tjoa, Ifael Y. Mauleti, Maria Mayasari, Iman Firmansyah, T. Mannaria Jayati, Michèle van Vugt, H. Rogier van Doorn, Raph L. Hamers, Erni J. Nelwan, Ralalicia Limato, Manzilina Mudia, Monik Alamanda, Helio Guterres, Enty Enty, Y. Ifael, Maria Mayasari Mauleti, Iman Firmansyah, May Hizrani, Anis Karuniawati, Taralan Tambunan, Amin Soebandrio, Decy Subekti, Iqbal Elyazar, Mutia Rahardjani, Fitria Wulandari, Reinout van Crevel, H. Rogier van Doorn, Vu Thi Lan Huong, Nga Do Ti Thuy, Sonia Lewycka, Alex Broom, Raph L. Hamers   +36 more
wiley   +1 more source

A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae

Microbiology Spectrum
Whole-genome sequencing of a clinical tigecycline non-susceptible Klebsiella pneumoniae strain reveals a novel T188A mutation in AcrA, raising awareness on its role in tigecycline resistance.
Yingchao Xu, Wenjia Wang, Wenya Su, Mingyu Wang, Hai Xu, Xuhua Zhang, Ling Li   +6 more
doaj   +1 more source

Clinical effectiveness of tigecycline in combination therapy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective multi-centre observational study

Journal of Intensive Care, 2023
Background Tigecycline has in vitro bacteriostatic activity against a broad spectrum of bacteria, including carbapenem-resistant Gram-negative bacteria (CR-GNB).
Kuang-Yao Yang, Chung-Kan Peng, Chau-Chyun Sheu, Yu-Chao Lin, Ming-Cheng Chan, Sheng-Huei Wang, Chia-Min Chen, Chih-Yu Chen, Zhe-Rong Zheng, Jia-Yih Feng, the T-CARE (Taiwan Critical Care and Infection) Group   +10 more
doaj   +1 more source

Accumulation of Histidine Reduce the Susceptibility of Vibrio splendidus Persister Cells to Tetracycline

Environmental Microbiology Reports, Volume 18, Issue 4, August 2026.
Histidine accumulation promotes tetracycline‐induced persister formation in V. splendidus. It enhances membrane potential and upregulating the efflux pump gene, thereby reducing antibiotic susceptibility. ABSTRACT Vibrio splendidus is an opportunistic pathogen widely distributed in marine environments, animal tissues and seabed sediments. It can infect
Yanan Li, Xinnan Pan, Jiayao Chen, Hong Ding, Yina Shao   +4 more
wiley   +1 more source

In vitro interference of tigecycline at subinhibitory concentrations on biofilm development by Enterococcus faecalis

, 2012
Objectives: Since biofilm formation is the hallmark of Enterococcus faecalis isolates, the aim of this study was to quantify biofilm formation in the presence of subinhibitory concentrations of tigecycline. Methods: Interference of tigecycline on biofilm
Giménez, María José, Alou Cervera, Luis, Maestre, Juan Ramón, Mendez, María Luisa, Granizo, Juan José, Prieto Prieto, José, Aguilar, Lorenzo, Mateo, María   +7 more
core   +1 more source

A novel mutation of ramR involved in tigecycline resistance in Klebsiella pneumoniae

Microbiology Spectrum
This study aims to investigate the novel potential tigecycline resistance mechanism in Klebsiella pneumoniae and provide new insights for the clinical treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae. In vitro experiments were
Yuyao Xu, Qi Chen, Chenhao Zhao, Xin Ma, Lei Wang, Feinan Qian, Xiangyu Guan, Hong Du, Haifang Zhang   +8 more
doaj   +1 more source

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

The Spectrum of Tigecycline-Induced Pancreatitis in Clinical Characteristics, Diagnosis, and Management

, 2023
Juan Pan,1 Chao Ye,2 Ling-Zhi Zhou,1 Zu-Yi Li,1 Juan Wang,2 Xin He,2 Shen-Jue Chen,2 Guang-Qing Zhou2 1Department of Pharmacy, Liuyang Hospital of Traditional Chinese Medicine, Changsha, Hunan, People’s Republic of China; 2Department of Pharmacy, The ...
Zhou LZ, Pan J, Chen SJ, Ye C, He X, Zhou GQ, Li ZY, Wang J   +7 more
core  

Acquisition of Tigecycline Resistance by Carbapenem-Resistant Klebsiella pneumoniae Confers Collateral Hypersensitivity to Aminoglycosides

Frontiers in Microbiology, 2021
Tigecycline is a last-resort antibiotic for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to broaden our understanding of the acquisition of collateral hypersensitivity by CRKP, as an evolutionary trade-off of ...
Hua-le Chen, Hua-le Chen, Yan Jiang, Mei-mei Li, Yao Sun, Jian-ming Cao, Cui Zhou, Xiao-xiao Zhang, Yue Qu, Tie-li Zhou   +9 more
doaj   +1 more source