Results 171 to 180 of about 198,310 (292)

A positive effect of selenoprotein on mammary gland: Selenoprotein P stabilizes tight junctions by reducing cell death through inflammation mitigation in mice. [PDF]

Redox Biol
Zhu M, Xu T, Lv H, Zhang Y, Luo J, Guo M.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Intratesticular creatine maintains spermatogenesis by defining tight junctions. [PDF]

Sci Rep
Kuribayashi S, Fukuhara S, Kitakaze H, Tsujimura G, Imanaka T, Ueda N, Takezawa K, Ikawa M, Nonomura N.   +8 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Trichinella spiralis cathepsin L damages the tight junctions of intestinal epithelial cells and mediates larval invasion. [PDF]

PLoS Negl Trop Dis, 2023
Liu RD, Meng XY, Li CL, Lin XZ, Xu QY, Xu H, Long SR, Cui J, Wang ZQ.   +8 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

New functions of B9D2 in tight junctions and epithelial polarity. [PDF]

Sci Rep
Caenen-Braz C, Bouzhir L, Dupuis-Williams P.   +2 more
europepmc   +1 more source

TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From MMP-Mediated Degradation. [PDF]

Pharm Res, 2023
Ahmadighadykolaei H, Lambert JA, Raeeszadeh-Sarmazdeh M.   +2 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

ALKBH5 Improves the Epithelial Cell Tight Junctions to Inhibit <i>Escherichia coli</i>-Induced Mastitis. [PDF]

Cells
Wu X, Xu H, Peng Y, Zhang R, Hu Y, Guo A, Hu C.   +6 more
europepmc   +1 more source