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Tight junctions in skin inflammation
Pflügers Archiv - European Journal of Physiology, 2016Inflammation of the skin is found after various external stimuli, e.g., UV radiation, allergen uptake, microbial challenge, or contact with irritants, as well as due to intrinsic, not always well-defined, stimuli, e.g., in autoimmune responses. Often, it is also triggered by a combination of both.
Katja, Bäsler, Johanna M, Brandner
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Journal of Dermatological Science, 2003
Tight junctions (=zonulae occludentes, TJs) function as an effective barrier in simple epithelia. Recent developments in the molecular biology of TJs revealed that TJs also exist in the stratum granulosum and contribute to barrier function in epidermis. Furthermore, several TJ-related junctions were identified in epidermis.
Kazumasa, Morita, Yoshiki, Miyachi
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Tight junctions (=zonulae occludentes, TJs) function as an effective barrier in simple epithelia. Recent developments in the molecular biology of TJs revealed that TJs also exist in the stratum granulosum and contribute to barrier function in epidermis. Furthermore, several TJ-related junctions were identified in epidermis.
Kazumasa, Morita, Yoshiki, Miyachi
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Perspectives on tight junction research
Annals of the New York Academy of Sciences, 2012The tight junction connects neighboring epithelial or endothelial cells. As a general function, it seals the paracellular pathway and thus prevents back‐leakage of just transported solutes and water. However, not all tight junctions are merely tight: some tight junction proteins build their own transport pathways by forming channels selective for small
Jörg-Dieter, Schulzke +3 more
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MOLECULAR ARCHITECTURE OF TIGHT JUNCTIONS
Annual Review of Physiology, 1998▪ Abstract The tight junction creates a regulated barrier in the paracellular pathway and, together with the actin-rich adherens junction, forms a functional unit called the apical junction complex. A growing number of tight junction–associated proteins have been identified, but functions are defined for only a few.
L L, Mitic, J M, Anderson
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Tight Junctions and Gap Junctions
2010Tight junctions have several major functions. They seal the intercellular space in epithelial and endothelial cell layers and prevent free paracellular passage of substances. They determine the polarity of epithelial cells by creating a boundary between the apical domain of the plasma membrane and the basolateral domain and prevent diffusion of lipids ...
Margit Pavelka, Jürgen Roth
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Tight Junctions and Tissue Barriers
Antioxidants & Redox Signaling, 2011The integrity and function of many vertebrate organs depend on cellular barriers that are mainly formed by intercellular protein complexes of the plasma membrane. These cell-cell contacts, tight junctions (TJs), exhibit the most apical localization in the lateral membrane; they regulate the permeability of the paracellular space between opposing ...
Ingolf E, Blasig, Reiner F, Haseloff
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Tight junctions and human diseases
Medical Electron Microscopy, 2003Tight junctions are intercellular junctions adjacent to the apical end of the lateral membrane surface. They have two functions, the barrier (or gate) function and the fence function. The barrier function of tight junctions regulates the passage of ions, water, and various macromolecules, even of cancer cells, through paracellular spaces.
Norimasa, Sawada +6 more
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Tight Junctions and Cell Polarity
Annual Review of Cell and Developmental Biology, 2006The tight junction is an intracellular junctional structure that mediates adhesion between epithelial cells and is required for epithelial cell function. Tight junctions control paracellular permeability across epithelial cell sheets and also serve as a barrier to intramembrane diffusion of components between a cell's apical and basolateral membrane ...
Shin, K, Fogg, VC, Margolis, B
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2006
Transport across epithelia occurs through both transcellular and paracellular pathways. Transcellular movement of solutes and ions through transporters and channels is energy-dependent, directional, highly selective and regulated. Paracellular transport occurs through tight junctions, which behave like charge- and size-selective channels, but with a ...
James Melvin Anderson +1 more
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Transport across epithelia occurs through both transcellular and paracellular pathways. Transcellular movement of solutes and ions through transporters and channels is energy-dependent, directional, highly selective and regulated. Paracellular transport occurs through tight junctions, which behave like charge- and size-selective channels, but with a ...
James Melvin Anderson +1 more
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Human airway epithelial tight junctions
Microscopy Research and Technique, 1997The flux of fluid, ions, macromolecules, and inflammatory cells across airway epithelium depends in part upon the integrity of its apico-lateral tight junctions. Without the correct balance of fluid and ions, the normal functioning of mucociliary clearance and the neural responsiveness of the airways cannot take place.
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