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Tight junctions and human diseases
Medical Electron Microscopy, 2003Tight junctions are intercellular junctions adjacent to the apical end of the lateral membrane surface. They have two functions, the barrier (or gate) function and the fence function. The barrier function of tight junctions regulates the passage of ions, water, and various macromolecules, even of cancer cells, through paracellular spaces.
Norimasa, Sawada +6 more
openaire +2 more sources
2006
Transport across epithelia occurs through both transcellular and paracellular pathways. Transcellular movement of solutes and ions through transporters and channels is energy-dependent, directional, highly selective and regulated. Paracellular transport occurs through tight junctions, which behave like charge- and size-selective channels, but with a ...
James Melvin Anderson +1 more
openaire +1 more source
Transport across epithelia occurs through both transcellular and paracellular pathways. Transcellular movement of solutes and ions through transporters and channels is energy-dependent, directional, highly selective and regulated. Paracellular transport occurs through tight junctions, which behave like charge- and size-selective channels, but with a ...
James Melvin Anderson +1 more
openaire +1 more source
Human airway epithelial tight junctions
Microscopy Research and Technique, 1997The flux of fluid, ions, macromolecules, and inflammatory cells across airway epithelium depends in part upon the integrity of its apico-lateral tight junctions. Without the correct balance of fluid and ions, the normal functioning of mucociliary clearance and the neural responsiveness of the airways cannot take place.
openaire +2 more sources
Paracellular permeability and tight junction regulation in gut health and disease
Nature Reviews Gastroenterology and Hepatology, 2023Arie Horowitz +2 more
exaly
Endothelial BACE1 Impairs Cerebral Small Vessels via Tight Junctions and eNOS
Circulation Research, 2022Haoyue Zhou, Yang Yao, Kaibin Shi
exaly

