Results 1 to 10 of about 27,271 (263)

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection [PDF]

PLoS Pathogens, 2016
HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication.
Glen M Chew, Gabriela M Webb, Benjamin Burwitz   +2 more
exaly   +5 more sources

DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy [PDF]

Cancers, 2019
Natural killer (NK) cells are lymphocytes of the innate immune response characterized by their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance between activating and inhibitory signals mediated by different ...
Fakhri Hassouneh, Alejandra Pera, Rafael Solana   +2 more
exaly   +3 more sources

Proinflammatory bone marrow niches and neutrophil activation are associated with TIGIT expression in multiple myeloma [PDF]

Annals of Hematology
Multiple Myeloma (MM) is the second most frequent hematologic malignancy in adults in the Western world. The bone marrow microenvironment plays a critical role in MM progression by supporting malignant plasma cell (PC) survival, immune evasion, and ...
Valeria Tomarchio, Francesca Arciprete, Monica Di Cecca, Giulia Maricchiolo, Viola Velardi, Mariantonietta Tafuri, Antonella Bianchi, Vittoria Morano, Barbara Mecorio, Luigi Rigacci, Anna Crescenzi, Maria Zingariello, Ombretta Annibali   +12 more
doaj   +2 more sources

TIGIT in cancer: from mechanism of action to promising immunotherapeutic strategies [PDF]

Cell Death and Disease
TIGIT immune checkpoint (IC) has attracted great interest in recent years. It belongs to the PVR-like protein family, and it inhibits T and NK cell cytotoxic activities.
Haozhe Cui, Mawieh Hamad, Eyad Elkord
doaj   +2 more sources

Expression of TIGIT in splenic and circulatory T cells from mice acutely infected with Toxoplasma gondii

Parasite, 2021
The surface protein TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain) has been characterized as an important regulator of cell-mediated immune responses in various infections.
Wang Shuai, Li Haoran, Zhang Fuqiang, Jiao Yuankai, Xie Qing, Zhang Zhenchao, Li Xiangrui   +6 more
doaj   +1 more source

TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients

OncoImmunology, 2021
Accumulating evidence indicates that immune checkpoint inhibitors (ICIs) can restore CD8+ cytotoxic T lymphocyte (CTL) functions in preclinical models of acute myeloid leukemia (AML).
Jana Rakova, Iva Truxova, Peter Holicek, Cyril Salek, Michal Hensler, Lenka Kasikova, Josef Pasulka, Monika Holubova, Marek Kovar, Daniel Lysak, Justin P. Kline, Zdenek Racil, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova   +14 more
doaj   +1 more source

TIGIT+ TIM-3+ NK cells are correlated with NK cell exhaustion and disease progression in patients with hepatitis B virus‑related hepatocellular carcinoma

OncoImmunology, 2021
The prognosis of hepatocellular carcinoma (HCC) is extremely poor, of which hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) accounts for the majority in China.
Lihua Yu, Xiaoli Liu, Xinhui Wang, Fengna Yan, Peng Wang, Yuyong Jiang, Juan Du, Zhiyun Yang   +7 more
doaj   +1 more source

Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies

Journal for ImmunoTherapy of Cancer, 2023
Background Inhibitory receptor T-cell Immunoreceptor with Ig and ITIM domains (TIGIT) expressed by Natural Killer (NK) and T cells regulates cancer immunity and has been touted as the next frontier in the development of cancer immunotherapeutics ...
Dean A Lee, Jeremiah L Oyer, Md Faqrul Hasan, Tayler J Croom-Perez, Liza D Robles-Carrillo, Sanjana Kumar, Brendan W Andersen, Brian P Tullius, Alicja J Copik, Amanda R Campbell, Thomas A Dieffenthaller, Catherine A Cash, Jonathan E Eloriaga, Meisam Naeimi Kararoudi   +13 more
doaj   +1 more source

Generating Anti-TIGIT and CD155 Monoclonal Antibodies for Tumor Immunotherapy

Pharmaceutical Fronts, 2022
Many studies have confirmed that the human poliovirus receptor (PVR; CD155) is related to tumor cell migration, invasion, and thus tumor progression. A PVR receptor binds its ligand T cell Ig and the ITIM domain (TIGIT) to inhibit the function of T and ...
Yu-Hang Duan, Yan-lin Bian, Jian-Wei Zhu
doaj   +1 more source

TIGIT immunosuppressive role in female reproductive system malignant neoplasms: from mechanism to therapy

Акушерство, гинекология и репродукция, 2020
Introduction. Malignant neoplasms of the female reproductive system (ovarian, endometrial, and cervical cancers) account for a significant proportion of female oncology morbidity and mortality. Standard treatment methods, including surgery, chemotherapy,
A. U. Khamadyanova, A. I. Romanova, A. N. Sklyar, A. P. Yamilova, M. G. Miranda Planas, G. D. Galeeva, S. R. Khakimov, A. A. Yakubov, S. K. Bikinyaev, Sh. M. Mammaev, A. A. Vardanyan, P. A. Kantaeva, T. R. Algirieva   +12 more
doaj   +1 more source