Results 91 to 100 of about 26,086 (200)

Expression of the immune checkpoint receptor TIGIT in Hodgkin’s lymphoma

, 2018
Hodgkin’s lymphoma (HL) is characterized by a high background of inflammatory cells which play an important role for the pathogenesis of the disease. T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory immune checkpoint receptor and a
Maximilian Lennartz, Andrea Hinsch, Stefan Steurer, Wenchao Li, Guido Sauter, Frank Jacobsen, David Dum, Andreas M. Luebke, Jakob R. Izbicki, Kristine Fischer, Martina Kluth, Waldemar Wilczak, Tim Mandelkow, Till Krech, Ronald Simon, Doris Höflmayer, Eike Burandt, Björn Wellge, Laura Pott, Nicolaus F. Debatin, Georgia Makrypidi-Fraune, Franziska Büscheck, Claudia Hube-Magg, Niclas C. Blessin, Sarah Minner, Ria Uhlig, Corinna Wittmer   +26 more
core   +1 more source

Treatment‐Free Remission in Chronic Myeloid Leukemia: Toward Precision and Personalized Approaches to Functional Cure

Cancer Science, EarlyView.
Immune surveillance of residual leukemic stem cells after tyrosine kinase inhibitor discontinuation involves coordinated NK‐cell, CTL, Treg, pDC, and neutrophil activity that predicts treatment‐free remission, while exhausted CTLs and Treg expansion predict relapse in chronic myeloid leukemia.
Hiroshi Ureshino, Shinya Kimura
wiley   +1 more source

TIGIT expression in extrahepatic cholangiocarcinoma and its impact on CD8 + T cell exhaustion: implications for immunotherapy

Extrahepatic cholangiocarcinoma (ECCA) is a malignant tumor. The precise role of T-cell immunoreceptor with Ig and ITIM domains (TIGIT), an emerging immunosuppressive receptor, in ECCA, and its impact on CD8+ T cell exhaustion (Tex) remains unclear.
Dehong Tan, Weijun Zhang, Tengqian Tang, Lang Gan, Jie Bai, Yan Jiang, Ping Zheng, Yu He, Wenhao Wang, Leida Zhang, Qianfei Zuo   +10 more
core   +1 more source

Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals [PDF]

, 2017
HIV-specific CD8+ T cells demonstrate an exhausted phenotype associated with increased expression of inhibitory receptors, decreased functional capacity, and a skewed transcriptional profile, which are only partially restored by antiretroviral treatment (
Deeks, Steven G, Ljunggren, Hans-Gustaf, Frederiksen, Juliet, Scharf, Lydia, Tauriainen, Johanna, Naji, Ali, Sönnerborg, Anders, Buggert, Marcus, Hecht, Frederick M, Betts, Michael R, Reyes-Terán, Gustavo, Karlsson, Annika C, Lund, Ole, Lund, O, Hecht, FM, Reyes-Teran, G, Ljunggren, H-G, Scharf, L,, Frederiksen, J, Naji, A, Deeks, SG, Tauriainen, J, Sonnerborg, A   +22 more
core   +1 more source

Turning Cancer Immunotherapy to the Emerging Immune Checkpoint TIGIT: Will This Break Through the Limitations of the Legacy Approach? [PDF]

The discovery of immune checkpoints (ICs) has pushed cancer treatment into the next era. As an emerging immune checkpoint, the TIGIT/CD155 axis inhibits the cytotoxicity of T and NK cells through multiple pathways.
Elkord, Eyad, Tripp, Ralph A, Cui, Haozhe, Eyad Elkord, Haozhe Cui   +4 more
core   +2 more sources

INHBB Promotes Colorectal Cancer Progression by Inducing CD8+ T Cell Exhaustion via the ACVR2B‐SMAD Signaling Axis

Cancer Science, EarlyView.
INHBB secreted by colorectal cancer cells activates ACVR2B‐SMAD signaling to induce CD8+ T‐cell exhaustion and drive tumor progression. SB431542 blocks this oncogenic immune‐suppressive axis. ABSTRACT To investigate the expression pattern, biological functions and regulatory mechanisms of inhibin beta B (INHBB) in colorectal cancer (CRC), and to ...
Guanghui Liu, Yuanhua Liu, Hongchao Zhao, Junfeng Sun, Hongwei Yang, Qingqing Ding   +5 more
wiley   +1 more source

Co-expression of PD-1, TIGIT and LAG-3 is a marker of HIV persistence during ART.

, 2016
(A) Frequency of CD4+ T cells co-expressing PD-1 and/or TIGIT and/or LAG-3 (PD-1/TIGIT/LAG-3 triple–(P-T-L-), PD-1 single + (P+), TIGIT single + (T+), LAG-3 single + (L+), PD-1/TIGIT double + (P+T+), TIGIT/LAG-3 double + (T+L+), PD-1/LAG-3 double + (P+L+)
Gabriela Khoury (663684), Rafick-Pierre Sékaly (118474), Rebecca Hoh (283494), Elizabeth Sinclair (10445), Peter Bacchetti (75155), Lorrie Epling (374736), Frederick M. Hecht (68366), Sandrina DaFonseca (340405), Sharon R. Lewin (130160), Wendy Hartogensis (285034), Steven G. Deeks (131630), Mariam B. Lawani (2879693), Nicolas Chomont (175516), Rémi Fromentin (659658), Wendy Bakeman (2879696), Marisela Killian (2879690)   +15 more
core   +1 more source

High ZFP36 Family Expression in Exhausted T Cells Is Associated With Impaired Antitumor Effector Function

Cancer Science, EarlyView.
Hypoxia induces ZFP36 family expression in exhausted CD8+ T cells, promoting the decay of AU‐rich effector cytokine mRNAs and suppressing TNF, IL2, and IFNG expression, thereby potentially contributing to impaired antitumor effector function. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by reinvigorating antitumor ...
Li Zhu, Youki Ueda, Yu Inutsuka, Toshifumi Ninomiya, Yuka Saeki, Takashi Inozume, Hiroko Watanabe, Takamasa Ishino, Hiroyoshi Y. Tanaka, Kazuo Yamashita, Masakiyo Sakaguchi, Joji Nagasaki, Yosuke Togashi   +12 more
wiley   +1 more source

Perturbed CD8⁺ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals [PDF]

, 2017
HIV-specific CD8+ T cells demonstrate an exhausted phenotype associated with increased expression of inhibitory receptors, decreased functional capacity, and a skewed transcriptional profile, which are only partially restored by antiretroviral treatment (
Ljunggren, Hans-Gustaf, Deeks, Steven G., Karlsson, Annika C., Hecht, Frederick Mm, Frederiksen, Juliet, Scharf, Lydia, Tauriainen, Johanna, Naji, Ali, Betts, Michael R., Sönnerborg, Anders, Buggert, Marcus, Reyes-Terán, Gustavo, Lund, Ole   +12 more
core   +1 more source

Advances in the Role of Chemokines in Microwave Ablation‐Based Combinatorial Immunotherapy

Cancer Science, EarlyView.
MWA can initiate antitumor immunity through tumor antigen release and innate immune activation, but iMWA may instead promote an immunosuppressive microenvironment. Combining MWA with immunotherapeutic strategies offers a promising approach to enhance systemic immunity and suppress residual and distant tumors.
Ruijie An, Ningning He, Wendong Gu
wiley   +1 more source