Results 101 to 110 of about 26,086 (200)

Immune сheckpoints in the context of external genital endometriosis

Медицинская иммунология
Endometriosis is a chronic recurrent disease with insufficiently studied pathogenesis. Endometriosis is known to share similar features with tumors. Thus, the outgrowth of endometrium-like tissue outside the uterus is the main feature of this condition ...
A. S. Belevich, M. I. Yarmolinskaya, S. A. Selkov, D. I. Sokolov   +3 more
doaj   +1 more source

Single‐Cell and Spatial Analysis Reveal the Differences Between Left‐Sided and Right‐Sided Colorectal Cancer

Cell Proliferation, EarlyView.
Single‐cell and spatial analysis revealed distinct CRC microenvironments by tumour laterality. Right‐sided tumours showed enhanced germinal centre B cells, CXCL13+ T cells, and organized TLS‐immune crosstalk via CCL19/21‐CCR7, suggesting better immunotherapy response.
Zongnai Zhang, Jiaqi Xu, Yingchao Wu, Tao Liu, Junling Zhang, Mai Zhou, Jie Qiao, Heng Pan, Xin Wang   +8 more
wiley   +1 more source

Update of the S1‐guideline atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS)

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare cutaneous neoplasms representing histomorphological, genetic as well as epigenetic variants of one disease spectrum. Both tumors manifest as nonspecific, often ulcerated nodules in chronically sun‐damaged skin. AFX is a well‐demarcated, often rapidly growing tumor.
Doris Helbig, Mirjana Ziemer, Diana Crisan, Edgar Dippel, Michael Erdmann, Uwe Hillen, Muemtaz Koeksal, Ulrike Leiter, Thomas Mentzel, Lars Erik Podleska, Jochen Utikal, Dagmar von Bubnoff, Carsten Weishaupt, Selma Ugurel   +13 more
wiley   +1 more source

Enhancement of Human Immunodeficiency Virus-Specific CD8⁺ T Cell Responses with TIGIT Blockade Involves Trogocytosis

Pathogens
Natural killer (NK) and CD8+ T cell function is compromised in human immunodeficiency virus type 1 (HIV-1) infection by increased expression of inhibitory receptors such as TIGIT (T cell immunoreceptor with Ig and ITIM domains).
Nazanin Ghasemi, Kayla A. Holder, Danielle P. Ings, Michael D. Grant   +3 more
doaj   +1 more source

Combining TAG‐72CAR with anti‐MUC16CAR improves the potency of ovarian cancer treatment

The FEBS Journal, EarlyView.
Tz‐KBBCAR, a combinatorial CAR targeting MUC16 and TAG‐72, enhances the precision of ovarian cancer immunotherapy. By requiring both tumour antigens for full activation, Tz‐KBBCAR was designed to eliminate MUC16+/TAG‐72+ cancer cells, while sparing MUC16+/TAG‐72‐ healthy cells.
Alicia Villatoro, Aurore Dougé, Klara Krpina, Lea‐Marie Schmitz, Christopher Forcados, Fatemeh Kaveh, Andrea Estrella Arias‐Díaz, Pascal Gelebart, Emmet McCormack, Renata Stripecke, Miguel Abal, Ben Davidson, Else Marit Inderberg, Sébastien Wälchli   +13 more
wiley   +1 more source

Inhibitory TIGIT signalling is dependent on T cell receptor activation

The immune checkpoint receptor TIGIT can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling and its regulation in T cells remain poorly defined.
Davis, Daniel M., Le Maistre, Lucy J., Zammit, William H., Cain, Stuart A.; id_orcid, Elliot, Thomas A. E., Humphries, Martin J., Worboys, Jonathan D.; id_orcid   +6 more
core   +3 more sources

Cutaneous lymphomas – an update

Histopathology, EarlyView.
Primary cutaneous lymphomas and lymphoproliferative disorders are defined by integrated clinical, histopathological, immunophenotypic and genetic features as diagnostic criteria also in the 5th edition of the WHO classification of haematolymphoid tumors.
Werner Kempf, Christina Mitteldorf
wiley   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

The Co-Inhibitory Receptor TIGIT Confers Tissue Protective Capacity to Tregs

The co-inhibitory receptor TIGIT suppresses excessive immune responses in autoimmune conditions while also restraining anti-tumor immunity. In viral infections, TIGIT alone does not affect viral control, but has been shown to limit tissue pathology ...
Panetti, Camilla
core   +2 more sources

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source