Results 121 to 130 of about 26,086 (200)

The Place of Therapeutic Apheresis in Severe Immune‐Related Adverse Events: A Scoping Review of Literature

Journal of Clinical Apheresis, Volume 41, Issue 6, December 2026.
ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the management of patients with cancer. However, they can induce breakdowns in immunologic tolerance, leading to autoimmune diseases, or immune related adverse events (irAEs). These irAEs can sometimes be life threatening, requiring aggressive management, such as immunosuppressant (IS) or
C. Vuillet, O. Moranne, D. Daubin, X. Quantin, P. Palassin, T. Kanouni, A. T. J. Maria, the MonRIO network (Montpellier Réseau Immuno‐Oncologie), Q. Thomas, P. Witkowski Durand Viel, C. Coustal, S. Faure, L. Meunier, L. Hountondji, R. Altwegg, C. Lesage, A. Lamoureux, G. Mouterde, S. Fabre, G. Taieb, F. Esselin, X. Ayriginac, C. Travert, B. Roch, F. Roubille, I. Raingeard, M. Le Quintrec, K. Dessaix, F. Garo, O. Moranne, J‐L. Faillie, P. Palassin, K. Klouche, B. Jauzelon, S. Bisiou, P. Rozier, A. TJ Maria   +36 more
wiley   +1 more source

Neoadjuvant Therapy for Non‐Small Cell Lung Cancer: Recent Advances and Future Directions

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Neoadjuvant therapy has become an integral component of the multidisciplinary management of resectable non–small cell lung cancer (NSCLC). The introduction of immune checkpoint inhibitors (ICIs) has transformed the perioperative treatment landscape by improving pathological response rates, reducing the risk of recurrence, and offering the ...
Hao An, Junfeng Zhao, Wenjie Chen, Ying Li, Yifei Yan, Chen Zhou, Ruyue Li, Xiujing Yao, Xue Dong, Xingying Yang, Yongjuan Hu, Jiaxuan Chen, Chuankun Han, Yingrui Bai, Yali Xu, Yintao Li   +15 more
wiley   +1 more source

Intratumoural Bacterial Co‐Occurrence is Associated With an Altered Tumour Immune Microenvironment and Poor Prognosis in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Alterations in the composition of the gut microbiota have been associated with colorectal cancer (CRC), with growing evidence indicating that specific microbes can have an impact on the tumour microenvironment. In this study, we investigated the associations of an oral pathobiont consortium comprising P. stomatis, F. nucleatum sensu lato and P.
Marina Rubio Garcia, Vicky Bronnec, Maïwenn Kerdreux, William Rosenbaum, Thyra Löwenmark, Anna Löfgren‐Burström, Ingrid Ljuslinder, Sofia Edin, Richard Palmqvist   +8 more
wiley   +1 more source

MLMP: A Methylation‐Associated lncRNA‐mRNA Prognostic Signature for Endometrial Carcinoma

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background Endometrial carcinoma (EC) is one of the most common gynecological malignancies. Aberrant DNA methylation (DNAm) is an important epigenetic alteration involved in cancer progression. Long non‐coding RNAs (LncRNAs) play critical roles in gene regulation and pathological processes.
Hong Kou, Mu Su, Jie Zhou, Yujie Liu, Yuan Wang, Jie Xing, Hongli Wang, Xueting Liu, Xinwen Wang, Yunyan Zhang, Sijia Liu   +10 more
wiley   +1 more source

Promising New Anti‐TIGIT Agents: Stealthy Allies in Cancer Immunotherapy

Clinical and Translational Science
TIGIT (T cell immunoreceptor with immunoglobulin and tyrosine‐based inhibitory motif (ITIM) domain), Vstm3, and VSIG9, are newly recognized immunological checkpoints. They are prominently expressed on CD4+ and CD8+ T cells, tumor‐infiltrating lymphocytes
Gatadi Srikanth, Durga Prasad Beda, Ashish Ranjan Dwivedi, Nandan Kumar Duddukuri, Srinivas Nanduri, Jitendra Patel   +5 more
doaj   +1 more source

MGMT unmethylation and high levels of CD47 and TIGIT indicate a poor prognosis in adult diffuse gliomas

Frontiers in Immunology
IntroductionIn 2021, the World Health Organization published a new classification system for central nervous system tumors. This study reclassified the adult diffuse glioma (ADG) into astrocytoma, oligodendroglioma, and glioblastoma (GBM) according to ...
Lingbo Ma, Yi Shi, Chang Li, Bin Deng, Jinfang Jiang, Yuwen Cao, Lianghai Wang, Hongyan Li   +7 more
doaj   +1 more source

Multi‐Omics Insights Into Circulating T‐Cell Metabolic Reprogramming and Treg Dysfunction in Moyamoya Disease

MedComm, Volume 7, Issue 11, November 2026.
The comprehensive study design is illustrated. A multi‐omics approach was used to characterize T‐cell metabolic alterations in MMD. By integrating mass cytometry (CyTOF), single‐cell RNA sequencing (scRNA‐seq), bulk RNA‐seq, metabolomics, and flow cytometry, we aimed to elucidate metabolic reprogramming in circulating T cells and Treg dysfunction in ...
Zhiyao Zheng, Qiheng He, Xinyu Ma, Bojian Zhang, Junsheng Li, Chenglong Liu, Siqi Mou, Wei Sun, Xiangjun Shi, Wenjing Wang, Dong Zhang, Peicong Ge, Jizong Zhao   +12 more
wiley   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, Volume 179, Issue 3, Page 486-515, November 2026.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

TIGIT+Tfh show poor B-helper function and negatively correlate with SARS-CoV-2 antibody titre [PDF]

Circulating follicular helper T cells (cTfh) can show phenotypic alterations in disease settings, including in the context of tissue-damaging autoimmune or anti-viral responses.
Lucy S. K. Walker, Yassin Elfaki, Kai Kisand, Chloe Rees-Spear, Andrea Rueda Gonzalez, Astrid Fabri, Laura E. McCoy, Lina Petersone, Pärt Peterson, Chunjing Wang, Elisavet Ntavli, Natalie M. Edner, Luke P. Houghton, Rachel Brown   +13 more
core   +1 more source

Proinflammatory bone marrow niches and neutrophil activation are associated with TIGIT expression in multiple myeloma

Annals of Hematology
Multiple Myeloma (MM) is the second most frequent hematologic malignancy in adults in the Western world. The bone marrow microenvironment plays a critical role in MM progression by supporting malignant plasma cell (PC) survival, immune evasion, and ...
Valeria Tomarchio, Francesca Arciprete, Monica Di Cecca, Giulia Maricchiolo, Viola Velardi, Mariantonietta Tafuri, Antonella Bianchi, Vittoria Morano, Barbara Mecorio, Luigi Rigacci, Anna Crescenzi, Maria Zingariello, Ombretta Annibali   +12 more
doaj   +1 more source