Results 21 to 30 of about 27,271 (263)
Arthritis Research & Therapy, 2021 Background T cell Ig and ITIM domain (TIGIT)/CD226 pathway has a critical role in regulating T cell responses and has come to the forefront in cancer as a promising immunotherapeutic target.
Wenli Li +12 more
doaj +1 more source
, 2017 Co-inhibitory receptors play a key role in regulating T cell responses and maintaining immune homeostasis. Their inhibitory function prevents autoimmune responses but also restricts the ability of T cells to mount effective immune responses against tumors or persistent pathogens.
Joller, Nicole, Kuchroo, Vijay K.
openaire +3 more sources
OncoImmunology, 2021 The inhibitory receptor TIGIT, as well as theectonucleotidases CD39 and CD73 constitute potential exhaustion markers for T cells. Detailed analysis of these markers can shed light into dysregulation of the T-cell response in acute myeloid leukemia (AML ...
F. Brauneck +11 more
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Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals. [PDF]
, 2017 HIV-specific CD8+ T cells demonstrate an exhausted phenotype associated with increased expression of inhibitory receptors, decreased functional capacity, and a skewed transcriptional profile, which are only partially restored by antiretroviral treatment (
Betts, Michael R +12 more
core +1 more source
Frontiers in Microbiology, 2021 As an immunosuppressive receptor, T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) play a critical part in cellular immune regulation mediated by pathogen infection.
Haoran Li +9 more
doaj +1 more source
Memory NK cell features exploitable in anticancer immunotherapy [PDF]
, 2019 Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived ...
Battella, Simone +5 more
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Research Progress of Immune Checkpoint TIGIT in Lung Cancer Immunotherapy
Chinese Journal of Lung Cancer, 2022 T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain (TIGIT) is a newly discovered immune checkpoint molecule, mainly expressed on the surface of T cells and natural killer (NK) cells.
Jieqiong WU +4 more
doaj +1 more source
TIGIT contributes to the regulation of 4-1BB and does not define NK cell dysfunction in glioblastoma
iScience, 2023 Summary: TIGIT is a receptor on human natural killer (NK) cells. Here, we report that TIGIT does not spontaneously induce inhibition of NK cells in glioblastoma (GBM), but rather acts as a decoy-like receptor, by usurping binding partners and regulating ...
Kyle B. Lupo +9 more
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Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT) [PDF]
, 2017 T cell immunoglobulin and ITIM domain (TIGIT) is an inhibitory receptor expressed on the surface of natural killer (NK) cells. TIGIT recognizes nectin and nectin-like adhesion molecules and thus plays a critical role in the innate immune response to ...
Berry, Richard +3 more
core +2 more sources
TIGIT checkpoint inhibition for myeloma [PDF]
Blood, 2018 In this issue of Blood, 2 companion papers by Guillerey et al1 and Minnie et al2 investigate mechanisms underlying immune effector dysfunction in myeloma and highlight T-cell immunoglobulin and ITIM domains (TIGIT) blockade as a novel checkpoint inhibition strategy.
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