Results 51 to 60 of about 27,271 (263)

The dual role of TIGIT in regulatory and effector T cells in chronic liver disease

JHEP Reports
Background & Aims: Effective control of chronic liver diseases (CLD) requires suppression of effector T cells by CD4+CD25+CD127low regulatory T cells (Tregs).
Amber G. Bozward, Scott P. Davies, Rémi Fiancette, Grace E. Wootton, Sian Faustini, Hin Fai Kwok, Naomi Richardson, Sean M. Morris, Kayani Kayani, Gary Middleton, Ye H. Oo   +10 more
doaj   +1 more source

Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice [PDF]

, 2016
Follicular helper T (Tfh) cells provide crucial help to germinal center B (GCB) cells for proper antibody production, and a specialized subset of regulatory T cells, follicular regulatory T (Tfr) cells, modulate this process.
Chen, Yuxin, Dent, Alexander L., Liu, Hong, Lu, Shan, Teuscher, Paula, Wang, Shixia, Wu, Hao, Xu, Lin-Lin   +7 more
core   +1 more source

Update in TIGIT Immune-Checkpoint Role in Cancer

Frontiers in Oncology, 2022
The in-depth characterization of cross-talk between tumor cells and T cells in solid and hematological malignancies will have to be considered to develop new therapeutical strategies concerning the reactivation and maintenance of patient-specific antitumor responses within the patient tumor microenvironment.
Tiziana Annese, Tiziana Annese, Roberto Tamma, Domenico Ribatti   +3 more
openaire   +4 more sources

TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia

OncoImmunology, 2018
While research on T cell exhaustion in context of cancer particularly focuses on CD8+ cytotoxic T cells, the role of inhibitory receptors on CD4+ T-helper cells have remained largely unexplored.
Kemal Catakovic, Franz Josef Gassner, Christoph Ratswohl, Nadja Zaborsky, Stefan Rebhandl, Maria Schubert, Markus Steiner, Julia Christine Gutjahr, Lisa Pleyer, Alexander Egle, Tanja Nicole Hartmann, Richard Greil, Roland Geisberger   +12 more
doaj   +1 more source

TIGIT Signaling Pathway Regulates Natural Killer Cell Function in Chronic Hepatitis B Virus Infection

Frontiers in Medicine, 2022
Background and ObjectivePersistent infection of hepatitis B virus (HBV) and liver damage in immune active chronic hepatitis B (CHB) could be partly due to the overreaction of natural killer (NK) cells, including pro-inflammatory cytokine secretion and ...
Juan Wang, Hongyan Hou, Lie Mao, Feng Wang, Jing Yu, Ying Luo, Qun Lin, Ziyong Sun   +7 more
doaj   +1 more source

Rorc restrains the potency of ST2+ regulatory T cells in ameliorating intestinal graft-versus-host disease [PDF]

, 2019
Soluble stimulation-2 (ST2) is increased during graft-versus-host disease (GVHD), while Tregs that express ST2 prevent GVHD through unknown mechanisms.
Blazar, Bruce R., Griesenauer, Brad, Hippen, Keli L., Liu, Hong, Loschi, Michael, Paczesny, Sophie, Ramadan, Abdulraouf, Reichenbach, Dawn K., Yang, Jinfeng, Zhang, Jilu   +9 more
core   +1 more source

Peculiarities of inhibitory receptor expression on effector and regulatory T cells in the context of immune checkpoint inhibitor therapy

Сибирский научный медицинский журнал
Inhibitory receptors PD-1, TIM-3, LAG-3, etc. – “immune checkpoints” – are expressed by activated effector T cells in order to limit the intensity of the immune response.
E. V. Batorov, P. V. Vasilchenko, E. R. Chernykh   +2 more
doaj   +1 more source

Prognostic value of CD155/TIGIT expression in patients with colorectal cancer.

PLoS ONE, 2022
IntroductionThe interaction of CD155 with its ligand, the T cell immunoreceptor with Ig and ITIM domains (TIGIT), is being studied owing to its potential to act as a target in the treatment of various solid tumors. However, the relationship between CD155
Daisuke Murakami, Kenji Matsuda, Hiromitsu Iwamoto, Yasuyuki Mitani, Yuki Mizumoto, Yuki Nakamura, Ibu Matsuzaki, Ryuta Iwamoto, Yuichi Takahashi, Fumiyoshi Kojima, Shin-Ichi Murata, Hiroki Yamaue   +11 more
doaj   +1 more source

IL‐2 Free Expansion of T Cells with Immunofilaments

Advanced Healthcare Materials, EarlyView.
Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck, Lea Weiss, René Classens, Carl G. Figdor, Roel Hammink   +4 more
wiley   +1 more source

Integrated bioinformatic analysis and cell line experiments reveal the significant role of the novel immune checkpoint TIGIT in kidney renal clear cell carcinoma

Frontiers in Oncology, 2023
BackgroundT cell immunoglobulin and ITIM domain (TIGIT) is a widely concerned immune checkpoint, which plays an essential role in immunosuppression and immune evasion.
Qi-Dong Xia, Bo Li, Jian-Xuan Sun, Chen-Qian Liu, Jin-Zhou Xu, Ye An, Meng-Yao Xu, Si-Han Zhang, Xing-Yu Zhong, Na Zeng, Si-Yang Ma, Hao-Dong He, Yu-Cong Zhang, Wei Guan, Heng Li, Shao-Gang Wang   +15 more
doaj   +1 more source