Results 11 to 20 of about 2,552 (169)
Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Pylkkö E +8 more
europepmc +2 more sources
Tiotropium bromide exerts anti-inflammatory effects during resistive breathing, an experimental model of severe airway obstruction [PDF]
International Journal of COPD, 2017 Dimitrios Toumpanakis,1,2 Konstantinos Loverdos,1,2 Vassiliki Tzouda,1,2 Vyronia Vassilakopoulou,1,2 Eleni Litsiou,1,2 Christina Magkou,3 Vassiliki Karavana,1,2 Michael Pieper,4 Theodoros Vassilakopoulos1,2 1First Critical Care Department, Pulmonary ...
Toumpanakis D +8 more
doaj +2 more sources
Pharmacokinetic Bioequivalence of Two Inhaled Tiotropium Bromide Formulations in Healthy Volunteers [PDF]
Clinical Drug Investigation, 2016 Jaime Algorta
exaly +2 more sources
Update on Long-Acting Anticholinergics in Children and Adolescents With Difficult and Severe Asthma
Frontiers in Pediatrics, 2022 Tiotropium bromide is the only long-acting muscarinic antagonist (LAMA) approved for treatment of patients aged ≥6 years old who have symptoms of uncontrolled asthma.
Francesca Santamaria +4 more
doaj +1 more source
International Journal of COPD, 2006 Therapy with bronchodilators forms the pharmacologic foundation of the treatment of patients with COPD. Bronchodilators can significantly lessen dyspnea, increase airflow, improve quality of life, and enhance exercise performance. While bronchodilators decrease airway resistance and lessen dynamic hyperinflation in patients with COPD, they have not ...
openaire +3 more sources
Сибирский онкологический журнал, 2023 The purpose of the study was to compare the efficacy of regular prolonged inhalation therapy with tiotropium bromide delivered via the Respimat inhaler and short-acting bronchodilator (SAB) therapy with ipratropium bromide/fenoterol in the perioperative ...
S. Yu. Dobner +8 more
doaj +1 more source
Acta Biomedica Scientifica, 2018 The aim of the study was to investigate the effectiveness of tiotropium bromide in patients with severe persistent asthma under conditions of real clinical practice.
A. F. Ivanov, B. A. Chernyak
doaj +1 more source
Muscarinic receptor M3 activation promotes fibrocytes contraction
Frontiers in Pharmacology, 2022 Fibrocytes are monocyte-derived cells able to differentiate into myofibroblasts-like cells. We have previously shown that they are increased in the bronchi of Chronic Obstructive Pulmonary Disease (COPD) patients and associated to worse lung function ...
Pauline Henrot +19 more
doaj +1 more source
Фармакоэкономика, 2017 The recently introduced novel drug combinations for the treatment of COPD are based on long-acting beta-agonists (vilantererol / umeclidinum bromide) and long-acting anticholinergics (olodaterol / tiotropium bromide).
E. G. Kosolapov +5 more
doaj +1 more source
COST-EFFECTIVENESS OF VILANEROL / UMECLIDINIUM VERSUS TIOTROPIUM IN SEVERE AND VERY SEVERE COPD
Фармакоэкономика, 2017 In accordance with currently accepted recommendations for the diagnosis and treatment of chronic obstructive pulmonary disease (COPD), both monotherapy with long-acting anticholinergics (LAAC) or combined therapy (LAAC / long-acting beta-agonists, LABA ...
E. G. Kosolapov +3 more
doaj +1 more source