Results 1 to 10 of about 17,692,743 (361)

Tissue Factor and Atherothrombosis.

Current Pharmaceutical Design, 2015
Atherosclerosis is a progressive disease characterized by the accumulation of lipids in medium to large sized arteries. Atherothrombosis is a term used to describe formation of a thrombus after rupture of an atherosclerotic plaque. Thrombosis can lead to
K. Tatsumi, N. Mackman
semanticscholar   +8 more sources

Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Sepsis-induced disseminated intravascular coagulopathy (DIC) remains a challenging clinical entity associated with significant morbidity and mortality.
Anna K. Tobiasch, Georg F. Lehner, Clemens Feistritzer, Andreas Peer, Birgit Zassler, Viktoria M. Neumair, Sebastian J. Klein, Michael Joannidis   +7 more
doaj   +2 more sources

Tissue Factor Structure and Function [PDF]

Scientifica, 2012
Tissue factor (TF) is an integral membrane protein that is essential to life. It is a component of the factor VIIa-TF complex enzyme and plays a primary role in both normal hemostasis and thrombosis.
S. Butenas
semanticscholar   +5 more sources

Tissue Factor [PDF]

Springer Reference Medizin, 2019
T. Stief
semanticscholar   +2 more sources

A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2021
In 2021, pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer deaths in the United States. This is largely due to a lack of symptoms and limited treatment options, which extend survival by only a few weeks.
Clayton S. Lewis, Aniruddha Karve, Kateryna Matiash, Timothy Stone, Jingxing Li, Jordon K. Wang, Henri H. Versteeg, Bruce J. Aronow, Syed A. Ahmad, Pankaj B. Desai, Vladimir Y. Bogdanov   +10 more
doaj   +1 more source

Tissue factor and tissue factor pathway inhibitor [PDF]

Anaesthesia, 2004
SummaryThe classical ‘cascade/waterfall’ hypothesis formulated to explain in vitro coagulation organised the amplification processes into the intrinsic and extrinsic pathways. Recent molecular biology and clinical data indicate that tissue factor/factor‐VII interaction is the primary cellular initiator of coagulation in vivo.
Peter Kam, G. Price, S. A. Thompson
openaire   +3 more sources

Tissue Factor-Enriched Neutrophil Extracellular Traps Promote Immunothrombosis and Disease Progression in Sepsis-Induced Lung Injury

Frontiers in Cellular and Infection Microbiology, 2021
BackgroundPatients with sepsis may progress to acute respiratory distress syndrome (ARDS). Evidence of neutrophil extracellular traps (NETs) in sepsis-induced lung injury has been reported.
Hao Zhang, Hao Zhang, Yilu Zhou, Mengdi Qu, Mengdi Qu, Ying Yu, Ying Yu, Zhaoyuan Chen, Zhaoyuan Chen, Shuainan Zhu, Shuainan Zhu, Kefang Guo, Kefang Guo, Wankun Chen, Wankun Chen, Changhong Miao, Changhong Miao   +16 more
doaj   +1 more source

Endothelial dysfunction and immunothrombosis in sepsis

Frontiers in Immunology, 2023
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction caused by a dysregulated or over-reactive host response to infection.
Eleni Maneta, Evmorfia Aivalioti, Simon Tual-Chalot, Besa Emini Veseli, Aikaterini Gatsiou, Kimon Stamatelopoulos, Kimon Stamatelopoulos, Konstantinos Stellos, Konstantinos Stellos, Konstantinos Stellos, Konstantinos Stellos   +10 more
doaj   +1 more source

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

medRxiv, 2020
Emerging data indicate that complement and neutrophils are involved in the maladaptive host immune response that fuels hyper-inflammation and thrombotic microangiopathy increasing the mortality rate in coronavirus disease 2019 (COVID-19).
P. Skendros, Alexandros Mitsios, A. Chrysanthopoulou, D. Mastellos, S. Metallidis, P. Rafailidis, Maria Ntinopoulou, Eleni N. Sertaridou, V. Tsironidou, C. Tsigalou, Maria Tektonidou, Theocharis G Konstantinidis, C. Papagoras, I. Mitroulis, G. Germanidis, John D Lambris, K. Ritis   +16 more
semanticscholar   +1 more source

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

Blood, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent pathogen responsible for the coronavirus disease 2019 (COVID-19). Since its emergence, the novel coronavirus has rapidly achieved pandemic proportions causing remarkably ...
E. D. Hottz, Isaclaudia G. Azevedo-Quintanilha, Lohanna Palhinha, Lívia Teixeira, Ester A. Barreto, Camila R. R. Pão, C. Righy, Sergio A L Franco, T. M. Souza, P. Kurtz, F. Bozza, P. Bozza   +11 more
semanticscholar   +1 more source