Results 1 to 10 of about 3,940,286 (283)
Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Sepsis-induced disseminated intravascular coagulopathy (DIC) remains a challenging clinical entity associated with significant morbidity and mortality.
Anna K. Tobiasch +7 more
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Comparative ex vivo analysis of Mim8 in thrombin generation assays triggered by activated factor XI or tissue factor [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Mim8 is a next-generation activated factor (F)VIII–mimetic, bispecific antibody, currently in clinical development for the prophylactic treatment of hemophilia A.
Wan Hui Ong Clausen +4 more
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The role of coagulation hemostasis for development of early-onset preeclampsia in low-risk patients
Акушерство, гинекология и репродукция, 2022 Aim: to determine a role of specific parameters of coagulation hemostasis for development of severe early-onset preeclampsia (еPE) in low-risk patients.Materials and Methods.
M. G. Nikolaeva +4 more
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Role of pyroptosis in hemostasis activation in sepsis
Frontiers in Immunology, 2023 Sepsis is frequently associated with hemostasis activation and thrombus formation, and systematic hemostatic changes are associated with a higher risk of mortality.
Chengrui Zhu +3 more
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Dysregulated coagulation system links to inflammation in diabetic kidney disease
Frontiers in Clinical Diabetes and Healthcare, 2023 Diabetic kidney disease (DKD) is a significant contributor to end-stage renal disease worldwide. Despite extensive research, the exact mechanisms responsible for its development remain incompletely understood. Notably, patients with diabetes and impaired
Mengyun Xiao +7 more
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Tissue factor and tissue factor pathway inhibitor [PDF]
Anaesthesia, 2004 Summary The classical ‘cascade/waterfall’ hypothesis formulated to explain in vitro coagulation organised the amplification processes into the intrinsic and extrinsic pathways.
G C, Price, S A, Thompson, P C A, Kam
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Frontiers in Physiology, 2021 Coagulation abnormalities and increased risk of atherothrombosis are common in patients with chronic kidney diseases (CKD). Mechanisms that alter renal hemostasis and lead to thrombotic events are not fully understood.
Abishek Iyer +14 more
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Tissue factor controversies [PDF]
Thrombosis Research, 2012 Tissue factor plays a primary role in both hemorrhage control and thrombosis depending upon whether its presentation is extravascular or intravascular. The molecular architecture and function of the tissue factor molecule and its role in the activations of factor IX and factor X have been elegantly elucidated but controversies prevail with respect to ...
Kenneth G, Mann +2 more
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Research and Practice in Thrombosis and Haemostasis, 2021 Objective Alterations in coagulation could mediate functional outcome in patients with hyperglycemia after acute ischemic stroke (AIS). We prospectively studied the effects of intensive versus standard glucose control on coagulation markers and their ...
Nina T. Gentile +8 more
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Tissue Factor–Factor VIIa Signaling [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2005 How does tissue factor (TF), whose principle role is to support clotting factor VIIa (FVIIa) in triggering the coagulation cascade, affect various pathophysiological processes? One of the answers is that TF interaction with FVIIa not only initiates clotting but also induces cell signaling via activation of G-protein–coupled protease activated receptors
L Vijaya Mohan, Rao, Usha R, Pendurthi
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