Results 1 to 10 of about 3,935,924 (184)

Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Sepsis-induced disseminated intravascular coagulopathy (DIC) remains a challenging clinical entity associated with significant morbidity and mortality.
Anna K. Tobiasch, Georg F. Lehner, Clemens Feistritzer, Andreas Peer, Birgit Zassler, Viktoria M. Neumair, Sebastian J. Klein, Michael Joannidis   +7 more
doaj   +2 more sources

Comparative ex vivo analysis of Mim8 in thrombin generation assays triggered by activated factor XI or tissue factor [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Mim8 is a next-generation activated factor (F)VIII–mimetic, bispecific antibody, currently in clinical development for the prophylactic treatment of hemophilia A.
Wan Hui Ong Clausen, Ties Latendorf, Rielana Stehr, Mirella Ezban, Jacob Lund   +4 more
doaj   +2 more sources

Local hemostasis disorders underlying endometric pathology

Акушерство, гинекология и репродукция, 2021
Introduction. Hemostasis is an equilibrium system that performs 2 bidirectional tasks: on the one hand, it prevents bleeding development, whereas on the other hand, it counters thrombogenesis.
E. Iu. Iupatov, I. G. Mustafin, T. E. Kurmanbaev, R. M. Nabiullina, K. M. Atayants, A. A. Shmidt, E. V. Frederiks   +6 more
doaj   +1 more source

Complement component C1q initiates extrinsic coagulation via the receptor for the globular head of C1q in adventitial fibroblasts and vascular smooth muscle cells

Immunity, Inflammation and Disease, 2023
Background Vascular diseases are highly associated with inflammation and thrombosis. Elucidating links between these two processes may provide a clearer understanding of these diseases, allowing for the design of more effective treatments. The activation
Christopher T. Freda, Wei Yin, Berhane Ghebrehiwet, David A. Rubenstein   +3 more
doaj   +1 more source

Tissue factor and tissue factor pathway inhibitor [PDF]

Anaesthesia, 2004
Summary The classical ‘cascade/waterfall’ hypothesis formulated to explain in vitro coagulation organised the amplification processes into the intrinsic and extrinsic pathways.
G C, Price, S A, Thompson, P C A, Kam
openaire   +2 more sources

Endothelial dysfunction and immunothrombosis in sepsis

Frontiers in Immunology, 2023
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction caused by a dysregulated or over-reactive host response to infection.
Eleni Maneta, Evmorfia Aivalioti, Simon Tual-Chalot, Besa Emini Veseli, Aikaterini Gatsiou, Kimon Stamatelopoulos, Kimon Stamatelopoulos, Konstantinos Stellos, Konstantinos Stellos, Konstantinos Stellos, Konstantinos Stellos   +10 more
doaj   +1 more source

Tissue factor controversies [PDF]

Thrombosis Research, 2012
Tissue factor plays a primary role in both hemorrhage control and thrombosis depending upon whether its presentation is extravascular or intravascular. The molecular architecture and function of the tissue factor molecule and its role in the activations of factor IX and factor X have been elegantly elucidated but controversies prevail with respect to ...
Kenneth G, Mann, Jolanta, Krudysz-Amblo, Saulius, Butenas   +2 more
openaire   +2 more sources

Tissue Factor–Factor VIIa Signaling [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
How does tissue factor (TF), whose principle role is to support clotting factor VIIa (FVIIa) in triggering the coagulation cascade, affect various pathophysiological processes? One of the answers is that TF interaction with FVIIa not only initiates clotting but also induces cell signaling via activation of G-protein–coupled protease activated receptors
L Vijaya Mohan, Rao, Usha R, Pendurthi
openaire   +2 more sources

A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2021
In 2021, pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer deaths in the United States. This is largely due to a lack of symptoms and limited treatment options, which extend survival by only a few weeks.
Clayton S. Lewis, Aniruddha Karve, Kateryna Matiash, Timothy Stone, Jingxing Li, Jordon K. Wang, Henri H. Versteeg, Bruce J. Aronow, Syed A. Ahmad, Pankaj B. Desai, Vladimir Y. Bogdanov   +10 more
doaj   +1 more source

Tissue Factor-Enriched Neutrophil Extracellular Traps Promote Immunothrombosis and Disease Progression in Sepsis-Induced Lung Injury

Frontiers in Cellular and Infection Microbiology, 2021
BackgroundPatients with sepsis may progress to acute respiratory distress syndrome (ARDS). Evidence of neutrophil extracellular traps (NETs) in sepsis-induced lung injury has been reported.
Hao Zhang, Hao Zhang, Yilu Zhou, Mengdi Qu, Mengdi Qu, Ying Yu, Ying Yu, Zhaoyuan Chen, Zhaoyuan Chen, Shuainan Zhu, Shuainan Zhu, Kefang Guo, Kefang Guo, Wankun Chen, Wankun Chen, Changhong Miao, Changhong Miao   +16 more
doaj   +1 more source