Results 1 to 10 of about 18,027,656 (296)

Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy [PDF]

open access: yesResearch and Practice in Thrombosis and Haemostasis
Background: Sepsis-induced disseminated intravascular coagulopathy (DIC) remains a challenging clinical entity associated with significant morbidity and mortality.
Anna K. Tobiasch   +7 more
doaj   +2 more sources

Tissue factor potentiates adherence of breast cancer cells to human umbilical vein endothelial cells under static and flow conditions [PDF]

open access: goldCell Adhesion & Migration, 2021
Tissue factor (TF) has been extensively studied for tumor metastasis, but its role in mediating cancer cell adhesion to vasculature remains unknown. This study aimed to measure the ability of TF to mediate the adhesion of breast cancer cells to human ...
Yanling Jin   +9 more
doaj   +2 more sources

Exploring the Mechanism of Chuanxiong Rhizoma against Thrombosis Based on Network Pharmacology, Molecular Docking and Experimental Verification

open access: yesMolecules, 2023
Chuanxiong rhizoma (CX) has been utilized for centuries as a traditional herb to treat blood stasis syndromes. However, the pharmacological mechanisms are still not completely revealed.
Shasha He   +3 more
doaj   +1 more source

Macrophage IL-1β-positive microvesicles exhibit thrombo-inflammatory properties and are detectable in patients with active juvenile idiopathic arthritis

open access: yesFrontiers in Immunology, 2023
ObjectiveIL-1β is a leaderless cytokine with poorly known secretory mechanisms that is barely detectable in serum of patients, including those with an IL-1β-mediated disease such as systemic juvenile idiopathic arthritis (sJIA).
Audrey Cambon   +24 more
doaj   +1 more source

Conformational Plasticity-Rigidity Axis of the Coagulation Factor VII Zymogen Elucidated by Atomistic Simulations of the N-Terminally Truncated Factor VIIa Protease Domain

open access: yesBiomolecules, 2021
The vast majority of coagulation factor VII (FVII), a trypsin-like protease, circulates as the inactive zymogen. Activated FVII (FVIIa) is formed upon proteolytic activation of FVII, where it remains in a zymogen-like state and it is fully activated only
Jesper J. Madsen, Ole H. Olsen
doaj   +1 more source

Potential biochemical markers of chronic bronchitis

open access: yesБюллетень сибирской медицины, 2021
The review systematizes modern data on the biochemical markers that can clarify the nature and the course of chronic bronchitis. The article describes markers associated with bronchopulmonary pathology, such as tumor necrosis factor alpha (TNFα ...
E. A. Kurtukov, Yu. I. Ragino
doaj   +1 more source

Local hemostasis disorders underlying endometric pathology

open access: yesАкушерство, гинекология и репродукция, 2021
Introduction. Hemostasis is an equilibrium system that performs 2 bidirectional tasks: on the one hand, it prevents bleeding development, whereas on the other hand, it counters thrombogenesis.
E. Iu. Iupatov   +6 more
doaj   +1 more source

Complement component C1q initiates extrinsic coagulation via the receptor for the globular head of C1q in adventitial fibroblasts and vascular smooth muscle cells

open access: yesImmunity, Inflammation and Disease, 2023
Background Vascular diseases are highly associated with inflammation and thrombosis. Elucidating links between these two processes may provide a clearer understanding of these diseases, allowing for the design of more effective treatments. The activation
Christopher T. Freda   +3 more
doaj   +1 more source

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

open access: yesmedRxiv, 2020
Emerging data indicate that complement and neutrophils are involved in the maladaptive host immune response that fuels hyper-inflammation and thrombotic microangiopathy increasing the mortality rate in coronavirus disease 2019 (COVID-19).
P. Skendros   +16 more
semanticscholar   +1 more source

Advances in Growth Factor Delivery for Bone Tissue Engineering

open access: yesInternational Journal of Molecular Sciences, 2021
Shortcomings related to the treatment of bone diseases and consequent tissue regeneration such as transplants have been addressed to some extent by tissue engineering and regenerative medicine. Tissue engineering has promoted structures that can simulate
É. R. Oliveira   +6 more
semanticscholar   +1 more source

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