Results 31 to 40 of about 18,027,656 (296)

Excess of heme induces tissue factor-dependent activation of coagulation in mice

Haematologica, 2015
An excess of free heme is present in the blood during many types of hemolytic anemia. This has been linked to organ damage caused by heme-mediated oxidative stress and vascular inflammation.
Erica M. Sparkenbaugh, P. Chantrathammachart, Shaobin Wang, William Jonas, D. Kirchhofer, D. Gailani, A. Gruber, R. Kasthuri, N. Key, N. Mackman, R. Pawlinski   +10 more
semanticscholar   +1 more source

Heparanase—A Link between Coagulation, Angiogenesis, and Cancer

Rambam Maimonides Medical Journal, 2012
Heparanase that was cloned from and is abundant in the placenta is implicated in cell invasion, tumor metastasis, and angiogenesis. Recently we have demonstrated that heparanase may also affect the hemostatic system in a non-enzymatic manner.
Yona Nadir, Benjamin Brenner
doaj   +1 more source

PAR2 Activation on Human Kidney Tubular Epithelial Cells Induces Tissue Factor Synthesis, That Enhances Blood Clotting

Frontiers in Physiology, 2021
Coagulation abnormalities and increased risk of atherothrombosis are common in patients with chronic kidney diseases (CKD). Mechanisms that alter renal hemostasis and lead to thrombotic events are not fully understood.
Abishek Iyer, Abishek Iyer, Tyrone L. R. Humphries, Evan P. Owens, Kong-Nan Zhao, Paul P. Masci, David W. Johnson, David W. Johnson, David Nikolic-Paterson, Glenda C. Gobe, Glenda C. Gobe, David P. Fairlie, David P. Fairlie, David A. Vesey, David A. Vesey   +14 more
doaj   +1 more source

Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices

Regenerative Biomaterials, 2018
In recent years, bone tissue engineering has emerged as a promising solution to the limitations of current gold standard treatment options for bone related-disorders such as bone grafts.
Tinke-Marie De Witte, L. Fratila‐Apachitei, A. A. Zadpoor, N. Peppas   +3 more
semanticscholar   +1 more source

Coagulation Factor IIIa (f3a) Knockdown in Zebrafish Leads to Defective Angiogenesis and Mild Bleeding Phenotype

Frontiers in Cell and Developmental Biology, 2022
Tissue factor (TF) is crucial for embryogenesis, as mice lacking TF are embryonically lethal (E10.5). This lethality may be attributed to defects in vascular development and circulatory failure, suggesting additional roles for TF in embryonic development
Saravanan Subramaniam, Saravanan Subramaniam, Jiandong Liu, Jiandong Liu, Craig Fletcher, Ramani Ramchandran, Hartmut Weiler   +6 more
doaj   +1 more source

Activation of Coagulation and Fibrinolysis in Acute Respiratory Distress Syndrome: a Prospective Pilot Study

Frontiers in Medicine, 2016
Introduction: Coagulation and fibrinolysis remain sparsely addressed with regards to acute respiratory distress syndrome (ARDS). We hypothesized that ARDS development might be associated with changes in plasma coagulation and fibrinolysis. Our aim was to
Agnese Ozolina, Agnese Ozolina, Marina Sarkele, Marina Sarkele, Olegs Sabelnikovs, Olegs Sabelnikovs, Andrejs Skesters, Inta Jaunalksne, Jelena Serova, Talis Ievins, Lars Jakob Bjertnæs, Indulis Vanags, Indulis Vanags   +12 more
doaj   +1 more source

Coagulation markers and functional outcome in acute ischemic stroke: Impact of intensive versus standard hyperglycemia control

Research and Practice in Thrombosis and Haemostasis, 2021
Objective Alterations in coagulation could mediate functional outcome in patients with hyperglycemia after acute ischemic stroke (AIS). We prospectively studied the effects of intensive versus standard glucose control on coagulation markers and their ...
Nina T. Gentile, A. Koneti Rao, Hannah Reimer, Fabiola Del Carpio‐Cano, Viswanathan Ramakrishnan, Qi Pauls, William G. Barsan, Askiel Bruno, for the iSPOT, Neurological Emergencies Treatment Trials Network (NETT) Investigators   +8 more
doaj   +1 more source

Indoxyl Sulfate Promotes Arterial Thrombosis in Rat Model via Increased Levels of Complex TF/VII, PAI-1, Platelet Activation as Well as Decreased Contents of SIRT1 and SIRT3

Frontiers in Physiology, 2018
Patients suffering from chronic kidney disease (CKD) are at a 20-fold higher risk of dying due to cardiovascular diseases (CVDs), primarily thrombosis following vascular injury. CKD is connected with retention of uremic toxins, especially indoxyl sulfate
Malgorzata Karbowska, Tomasz W. Kaminski, Beata Znorko, Tomasz Domaniewski, Tomasz Misztal, Tomasz Rusak, Anna Pryczynicz, Katarzyna Guzinska-Ustymowicz, Krystyna Pawlak, Dariusz Pawlak   +9 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Transforming growth factor-β in stem cells and tissue homeostasis

Bone Research, 2018
TGF-β 1–3 are unique multi-functional growth factors that are only expressed in mammals, and mainly secreted and stored as a latent complex in the extracellular matrix (ECM).
Xin Xu, Liwei Zheng, Q. Yuan, G. Zhen, Janet L. Crane, Xuedong Zhou, Xu Cao   +6 more
semanticscholar   +1 more source