Results 61 to 70 of about 2,653,429 (308)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A multiple-instance scoring method to predict tissue-specific cis-regulatory motifs and regions

, 2009
Transcription is the central process of gene regulation. In higher eukaryotes, the transcription of a gene is usually regulated by multiple cis-regulatory regions (CRRs).
Jin Gu
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Low oxygen concentrations impair tissue development in tissue-engineered cardiovascular constructs

, 2012
Cardiovascular tissue engineering has shown considerable progress, but in vitro tissue conditioning to stimulate the development of a functional extracellular matrix still needs improvement.
Baaijens, FPT Frank, Vlimmeren, M.A.A. van, Stoop, R, Broek, van den, W.J.T., Driessen - Mol, A., Bouten, C.V.C., Bouten, CVC Carlijn, Stoop, R., Baaijens, F.P.T., Vlimmeren, van, M.A.A., Driessen-Mol, A Anita, Oomens, CWJ Cees, Bouten, C.V.C.; id_orcid, Broek, M. van den, Driessen-Mol, A., Oomens, C.W.J., Vlimmeren, MAA Marijke van, Broek, WJT van den   +17 more
core   +1 more source

Coagulation markers and functional outcome in acute ischemic stroke: Impact of intensive versus standard hyperglycemia control

Research and Practice in Thrombosis and Haemostasis, 2021
Objective Alterations in coagulation could mediate functional outcome in patients with hyperglycemia after acute ischemic stroke (AIS). We prospectively studied the effects of intensive versus standard glucose control on coagulation markers and their ...
Nina T. Gentile, A. Koneti Rao, Hannah Reimer, Fabiola Del Carpio‐Cano, Viswanathan Ramakrishnan, Qi Pauls, William G. Barsan, Askiel Bruno, for the iSPOT, Neurological Emergencies Treatment Trials Network (NETT) Investigators   +8 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA

, 1993
Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ, Peters, DK, P J Lachmann, D K Peters, P W Mathieson, Oliveira, DBG, R Würzner, D B Oliveria, Mathieson, PW, Würzner, R, Oliveria, DB   +10 more
core   +1 more source

Not more than three tissue kallikreins identified from organs of the guinea pig [PDF]

, 1999
The large and varied multigene families of tissue kallikreins of rat and mouse are considered to selectively release as many bioactive peptides. In order to determine whether a similar family of enzymes is expressed in the organs of the guinea pig ...
Fiedler, F., Bhoola, K. D., Betz, G., Hinz, H., Lottspeich, F., Raidoo, D. M.   +5 more
core   +1 more source

Adipocytes express tissue factor and FVII and are procoagulant in a TF/FVIIa-dependent manner

Upsala Journal of Medical Sciences, 2019
Background: Tissue factor (TF) combined with its ligand FVII initiates blood coagulation and intracellular signaling. Obese and type 2 diabetic subjects have increased TF expression in their adipose tissue and an increased risk for thrombotic ...
Desirée Edén, Grigorios Panagiotou, Dariush Mokhtari, Jan W. Eriksson, Mikael Åberg, Agneta Siegbahn   +5 more
doaj   +1 more source

Coagulation Factor IIIa (f3a) Knockdown in Zebrafish Leads to Defective Angiogenesis and Mild Bleeding Phenotype

Frontiers in Cell and Developmental Biology, 2022
Tissue factor (TF) is crucial for embryogenesis, as mice lacking TF are embryonically lethal (E10.5). This lethality may be attributed to defects in vascular development and circulatory failure, suggesting additional roles for TF in embryonic development
Saravanan Subramaniam, Saravanan Subramaniam, Jiandong Liu, Jiandong Liu, Craig Fletcher, Ramani Ramchandran, Hartmut Weiler   +6 more
doaj   +1 more source