Results 21 to 30 of about 66,322 (262)

Metalloproteinases and tissue inhibitors of metalloproteinases in exudative pleural effusions [PDF]

European Respiratory Journal, 2005
The aim of this study was to assess the expression of several metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in exudative pleural effusions, and their relationship with inflammatory and fibrinolytic mediators in parapneumonic effusions.The study included 51 parapneumonic effusions (30 empyema or complicated parapneumonic,
D, Iglesias, J, Alegre, C, Alemán, E, Ruíz, T, Soriano, L I, Armadans, R M, Segura, A, Anglés, J, Monasterio, T Fernández, de Sevilla   +9 more
openaire   +2 more sources

Inhibition of Tissue Matrix Metalloproteinases Interferes with Mycobacterium tuberculosis-Induced Granuloma Formation and Reduces Bacterial Load in a Human Lung Tissue Model

Frontiers in Microbiology, 2017
Granulomas are hallmarks of pulmonary tuberculosis (TB) and traditionally viewed as host-protective structures. However, recent evidence suggest that Mycobacterium tuberculosis (Mtb) uses its virulence factors to stimulate the formation of granuloma.
Venkata R. Parasa, Jagadeeswara R. Muvva, Jeronimo F. Rose, Clara Braian, Susanna Brighenti, Maria Lerm   +5 more
doaj   +1 more source

The activity of matrix metalloproteinases and the concentration of their tissue inhibitors in the blood serum of patients with type 2 diabetes mellitus, depending on the stage of compensation of the disease

Сибирский научный медицинский журнал, 2021
The aim of the study was to test the hypothesis on the possible reason for the decrease in the activity of matrix metalloproteinases (MMPs) as a consequence of the high concentration of their tissue inhibitors (TIMPs) in the blood serum of patients with ...
A. V. Zubova, A. R. Kolpakov, G. S. Russkikh, O. N. Poteryaeva   +3 more
doaj   +1 more source

Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9

Matrix Biology, 2023
Extracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments.
Sasha Coates-Park, Carolyn Lazaroff, Sadeechya Gurung, Josh Rich, Alexandra Colladay, Maura O'Neill, Georgina S. Butler, Christopher M. Overall, William G. Stetler-Stevenson, David Peeney   +9 more
openaire   +2 more sources

Peroxynitrite inactivates human‐tissue inhibitor of metalloproteinase‐4 [PDF]

FEBS Letters, 2008
Peroxynitrite, via post‐translational modifications to target proteins, contributes to cardiovascular injury and cancer. Since tissue inhibitor of metalloproteinase‐4 (TIMP‐4), the activity of which is impaired in both pathological conditions, has several amino acid residues susceptible to peroxynitrite, we investigated its role as a potential target ...
Donnini, Sandra, Monti, M., Roncone, R., Morbidelli, Lucia, Rocchigiani, M., Oliviero, Salvatore, Casella, L., Giachetti, A., Schulz, R., Ziche, Marina   +9 more
openaire   +5 more sources

Clinical Investigation of Matrix Metalloproteinases, Tissue Inhibitors of Matrix Metalloproteinases, and Matrix Metalloproteinase/Tissue Inhibitors of Matrix Metalloproteinase Complexes and Their Networks in Apical Periodontitis [PDF]

Journal of Endodontics, 2016
This clinical study investigated the levels of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) and respective forms (MMP/TIMP complexes) in apical periodontitis to determine their networks in the development of clinical/radiographic features, thus quantifying the levels of endotoxins (lipopolysaccharides) present in primarily infected ...
Frederico C. Martinho, Flávia F.C. Teixeira, Flávia G.R. Cardoso, Nádia S. Ferreira, Gustavo G. Nascimento, Cláudio A.T. Carvalho, Márcia C. Valera   +6 more
openaire   +3 more sources

The Effects of Botulinum Toxin A on Collagen Synthesis, Expression of MMP (matrix metalloproteinases)-1,2,9 and TIMP (tissue inhibitors of metalloproteinase)-1 in the Keloid Fibroblasts [PDF]

Archives of Aesthetic Plastic Surgery, 2013
Keloids are characterized by excessive extracelluar matrix (ECM) deposition such as collagen, fibronectin, elastin, and proteoglycans in the dermis. Recently, the use of botulinum toxin A (BTXA) in the treatment of keloids have had good results.
Tai Suk Roh, Jong Won Hong, Won Jai Lee, Han-su Yoo, Dae Hyun Lew, Young Seok Kim   +5 more
doaj   +1 more source

Matrix metalloproteinases in the process of invasion and metastasis of breast cancer [PDF]

Archive of Oncology, 2006
Metastatic cascade in malignant tumors, including breast cancer, starts with localized invasion of the host tissue. This process, requiring that tumor cells separate from each other, includes loss of homotypic and heterotypic cell adhesion and cell-cell ...
Konjević Gordana, Stanković Sandra
doaj   +1 more source

Tissue Inhibitor of Metalloproteinases-4. The road less traveled

Molecular Cancer, 2008
Tissue inhibitors of metalloproteinases (TIMPs) regulate diverse processes, including extracellular matrix (ECM) remodeling, and growth factors and their receptors' activities through the inhibition of matrix metalloproteinases (MMPs).
Ceballos Gisela, Pozo Luis, Melendez-Zajgla Jorge, Maldonado Vilma   +3 more
doaj   +1 more source

Metalloproteinases as mediators of inflammation and the eyes: molecular genetic underpinnings governing ocular pathophysiology [PDF]

International Journal of Ophthalmology, 2017
There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases (MMPs); the Zn (2+)-dependent endoproteases in eye health along with ...
Mahavir Singh, Suresh C Tyagi
doaj   +1 more source