Results 1 to 10 of about 62,626 (262)

Anti-titin antibody is associated with more frequent hospitalization to manage thymoma-associated myasthenia gravis

Frontiers in Neurology, 2022
Background and purposeAnti-titin antibodies are antistriational antibodies associated with thymoma-associated myasthenia gravis (MG). We evaluated whether the patients with anti-titin antibody are more frequently hospitalized to manage thymoma-associated
Ki Hoon Kim, Seung Woo Kim, Jinhyuk Cho, Hye Yoon Chung, Ha Young Shin   +4 more
doaj   +2 more sources

Protein Quality Control at the Sarcomere: Titin Protection and Turnover and Implications for Disease Development

Frontiers in Physiology, 2022
Sarcomeres are mainly composed of filament and signaling proteins and are the smallest molecular units of muscle contraction and relaxation. The sarcomere protein titin serves as a molecular spring whose stiffness mediates myofilament extensibility in ...
Sebastian Kötter, Martina Krüger
doaj   +2 more sources

The skeletal muscle circadian clock regulates titin splicing through RBM20

eLife, 2022
Circadian rhythms are maintained by a cell-autonomous, transcriptional–translational feedback loop known as the molecular clock. While previous research suggests a role of the molecular clock in regulating skeletal muscle structure and function, no ...
Lance A Riley, Xiping Zhang, Collin M Douglas, Joseph M Mijares, David W Hammers, Christopher A Wolff, Neil B Wood, Hailey R Olafson, Ping Du, Siegfried Labeit, Michael J Previs, Eric T Wang, Karyn A Esser   +12 more
doaj   +2 more sources

E3-ligase knock down revealed differential titin degradation by autopagy and the ubiquitin proteasome system

Scientific Reports, 2021
The sarcomere protein titin is a major determinant of cardiomyocyte stiffness and ventricular distensibility. The constant mechanical stress on titin requires well-controlled protein quality control, the exact mechanisms of which have not yet been fully ...
Erik Müller, Senem Salcan, Sabine Bongardt, David Monteiro Barbosa, Martina Krüger, Sebastian Kötter   +5 more
doaj   +2 more sources

RBM20, a Therapeutic Target to Alleviate Myocardial Stiffness via Titin Isoforms Switching in HFpEF

Frontiers in Cardiovascular Medicine, 2022
Increased myocardial stiffness is critically involved in heart diseases with impaired cardiac compliance, especially heart failure with preserved ejection fraction (HFpEF). Myocardial stiffness mainly derives from cardiomyocyte- and extracellular matrix (
Na Li, Weijian Hang, Hongyang Shu, Ning Zhou   +3 more
doaj   +2 more sources

The Giant Protein Titin’s Role in Cardiomyopathy: Genetic, Transcriptional, and Post-translational Modifications of TTN and Their Contribution to Cardiac Disease

Frontiers in Physiology, 2019
Dilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death and heart transplant. DCM is inherited in approximately 50% of cases, in which the most frequent genetic defects are truncation variants of the titin gene (TTNtv). TTN
Charles A. Tharp, Mary E. Haywood, Orfeo Sbaizero, Matthew R. G. Taylor, Luisa Mestroni   +4 more
doaj   +2 more sources

Truncated titin is structurally integrated into the human dilated cardiomyopathic sarcomere

The Journal of Clinical Investigation, 2023
Heterozygous (HET) truncating variant mutations in the TTN gene (TTNtvs), encoding the giant titin protein, are the most common genetic cause of dilated cardiomyopathy (DCM).
Dalma Kellermayer, Hedvig Tordai, Balázs Kiss, György Török, Dániel M. Péter, Alex Ali Sayour, Miklós Pólos, István Hartyánszky, Bálint Szilveszter, Siegfried Labeit, Ambrus Gángó, Gábor Bedics, Csaba Bödör, Tamás Radovits, Béla Merkely, Miklós S.Z. Kellermayer   +15 more
doaj   +2 more sources

Individual globular domains and domain unfolding visualized in overstretched titin molecules with atomic force microscopy. [PDF]

PLoS ONE, 2014
Titin is a giant elastomeric protein responsible for the generation of passive muscle force. Mechanical force unfolds titin's globular domains, but the exact structure of the overstretched titin molecule is not known.
Zsolt Mártonfalvi, Miklós Kellermayer
doaj   +6 more sources

Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle

eLife, 2020
The giant muscle protein titin is a major contributor to passive force; however, its role in active force generation is unresolved. Here, we use a novel titin-cleavage (TC) mouse model that allows specific and rapid cutting of elastic titin to quantify ...
Yong Li, Anthony L Hessel, Andreas Unger, David Ing, Jannik Recker, Franziska Koser, Johanna K Freundt, Wolfgang A Linke   +7 more
doaj   +2 more sources

Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D

Frontiers in Physiology, 2020
The giant protein titin performs structure-preserving functions in the sarcomere and is important for the passive stiffness (Fpassive) of cardiomyocytes. Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy,
Melissa Herwig, Melissa Herwig, Melissa Herwig, Melissa Herwig, Detmar Kolijn, Detmar Kolijn, Detmar Kolijn, Detmar Kolijn, Mária Lódi, Mária Lódi, Mária Lódi, Mária Lódi, Mária Lódi, Soraya Hölper, Árpád Kovács, Árpád Kovács, Árpád Kovács, Zoltán Papp, Kornelia Jaquet, Kornelia Jaquet, Kornelia Jaquet, Peter Haldenwang, Cris Dos Remedios, Peter H. Reusch, Andreas Mügge, Andreas Mügge, Marcus Krüger, Marcus Krüger, Jens Fielitz, Jens Fielitz, Wolfgang A. Linke, Nazha Hamdani, Nazha Hamdani, Nazha Hamdani, Nazha Hamdani   +34 more
doaj   +2 more sources