Results 91 to 100 of about 62,626 (262)

Giant FAZ10 is required for flagellum attachment zone stabilization and furrow positioning in Trypanosoma brucei [PDF]

open access: yes, 2017
The flagellum and flagellum attachment zone (FAZ) are important cytoskeletal structures in trypanosomatids, being required for motility, cell division and cell morphogenesis.
Baqui, Munira M.A.   +3 more
core   +1 more source

Proteome‐Wide Analysis of Human Deletions

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Protein deletions are frequent among both natural and pathogenic variations. Many of them are misclassified in variation databases and the literature. Nonsense‐mediated decay prevents the expression of many nucleotide deletions. Many variants classified as protein deletions are not expressed at all.
Haoyang Zhang   +2 more
wiley   +1 more source

An Explanation of Shortening Heat Generation and Mechanical Performance Enhancement during Muscle Stretch

open access: yesThe Scientific World Journal, 2001
Titin is an extraordinary long multidomain protein spanning half of the sarcomeric unit. One end of the titin filament is known to emerge from the Z-line, but the precise localization of the other end is still a matter of debate.
Dan Eremia
doaj   +1 more source

Titin Isoform Size is Not Correlated with Thin Filament Length in Rat Skeletal Muscle

open access: yesFrontiers in Physiology, 2014
The mechanisms controlling thin filament length in muscle remain controversial. It was recently reported that thin filament length was related to titin size, and that the latter might be involved in thin filament length determination.
Marion Lewis Greaser   +1 more
doaj   +1 more source

Revealing the Diverse Allergenic Protein Repertoire of Six Widely Consumed Crab Species: A Species‐Specific Allergen in King Crab

open access: yesAllergy, EarlyView.
This study comprehended the allergen profiles of six edible crab species using proteomic and transcriptomic analyses and identified 11 putative allergens. King crab has a distinct protein and allergen profile, with the discovery of malate dehydrogenase as a novel king crab‐specific allergen registered as Para c 11.
Shanshan Li   +11 more
wiley   +1 more source

Heterogeneous and rate-dependent streptavidin-biotin unbinding revealed by high-speed force spectroscopy and atomistic simulations [PDF]

open access: yes, 2019
Receptor-ligand interactions are essential for biological function and their binding strength is commonly explained in terms of static lock-and-key models based on molecular complementarity.
Gonzalez, Laura   +4 more
core   +4 more sources

Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Cerebral palsy, caused by non‐progressive brain injury, is frequently accompanied by skeletal muscle alterations. This review synthesizes current evidence from muscle biopsy studies, revealing cellular and molecular adaptations in muscle tissue. Abstract Cerebral palsy (CP), the most prevalent childhood‐onset motor disability, frequently entails ...
Sebastian Edman   +4 more
wiley   +1 more source

Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function

open access: yesActa Neuropathologica Communications, 2017
Summary Myopathies encompass a wide variety of acquired and hereditary disorders. The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties.
Andreas Unger   +9 more
doaj   +1 more source

Compliant Titin Isoform Content Is Reduced in Left Ventricles of Sedentary Versus Active Rats

open access: yesFrontiers in Physiology, 2020
A sedentary lifestyle is associated with increased cardiovascular risk factors and reduced cardiac compliance when compared to a lifestyle that includes exercise training.
Charles S. Chung   +3 more
doaj   +1 more source

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