Results 111 to 120 of about 62,626 (262)
002 Titin Truncation Provides a Sensitised Template for Cardio-Depressant Effects of Alcohol [PDF]
, 2020 César Santiago +6 more
openalex +1 more source
Journal of Clinical Medicine, 2020 Titin is the largest human protein and an essential component of the cardiac sarcomere. With multiple immunoglobulin(Ig)-like domains that serve as molecular springs, titin contributes significantly to the passive tension, systolic function, and ...
Charles A. Tharp +2 more
semanticscholar +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.A multicenter adult gMG cohort from five tertiary centers in China (N = 118) received efgartigimod 10 mg/kg IV weekly × 4. Early minimal symptom expression (MSE) response was defined as MG‐ADL ≤ 1 sustained ≥ 4 weeks and assessed within 4 weeks. A three‐factor nomogram (bulbar MG‐ADL subscore, FVC% predicted, serum IgG) was developed in the derivation ...
Yufang Yang +12 more
wiley +1 more source
Autoantibodies in myasthenia gravis: cluster analysis and clinical correlations
Frontiers in NeurologyObjectiveThis study aimed to explore autoantibody clusters and their correlations with clinical features in 644 myasthenia gravis (MG) patients.MethodsMedical records of 664 MG patients were reviewed. Five autoantibodies (AChR, MuSK, titin, RyR, and LRP4)
Xupeng Sun +9 more
doaj +1 more source
Frontiers in Physiology, 2016 Titin is a giant scaffold protein with multiple functions in striated muscle physiology. Due to the elastic I-band domains and the filament-like integration in the half-sarcomere titin is an important factor for sarcomere assembly and serves as an ...
Martina eKrüger, Sebastian eKötter
doaj +1 more source
The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif. [PDF]
, 1993 A common feature shared by myosin-binding proteins from a wide variety of species is the presence of a variable number of related internal motifs homologous to either the Ig C2 or the fibronectin (Fn) type III repeats.
Fischman, DA +5 more
core
Mimics and Diagnostic Pitfalls of Anti‐Adenylate Kinase 5 Limbic Encephalitis
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.Mimics of anti‐AK5 encephalitis are common and that misdiagnosis is often driven by non‐specific symptoms and clinically irrelevant antibody results. The absence of cognitive impairment as a major symptom, prominence of psychiatric and behavioral symptoms, isolated from serum positivity or low CSF antibody titers (< 1:100), and objective clinical ...
Jierui Wang +5 more
wiley +1 more source
Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies
eLifeThe giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse.
Judith Hüttemeister +9 more
doaj +1 more source
Frontiers in Physiology, 2016 Titin is a giant protein spanning from the Z-disk to the M-band of the cardiac sarcomere. In the I-band titin acts as a molecular spring, contributing to passive mechanical characteristics of the myocardium throughout a heartbeat.
Hannah C. Pulcastro +6 more
doaj +1 more source
Effect of Load on Non‐Muscle Myosin 2 Paralog Filaments in a Biomimetic Contractile Actin Array
Small, Volume 22, Issue 3, 13 January 2026.The main paralogs of non‐muscle myosin 2 are studied on a micropatterned array of anti‐parallel actin filaments. This sarcomere‐like platform reveals myosin's load‐dependent behavior, and the resulting tension is quantified using embedded FRET sensors for both myosin and anchored actin.
Philip Bleicher +8 more
wiley +1 more source