Results 51 to 60 of about 62,626 (262)
Stretching Single Domain Proteins: Phase Diagram and Kinetics of Force-Induced Unfolding
, 1999 Single molecule force spectroscopy reveals unfolding of domains in titin upon stretching. We provide a theoretical framework for these experiments by computing the phase diagrams for force-induced unfolding of single domain proteins using lattice models.
Bell +19 more
core +3 more sources
European Journal of Histochemistry, 2009 Titin, a sarcomeric giant protein, plays crucial roles in muscle assembly, elasticity and stability. Little is known about titin adaptation to endurance exercise.
M Bellafiore +6 more
doaj +1 more source
Attenuated titin protein expression is associated with advanced stages of ovarian cancer
Molecular Therapy: OncologyThis study explores the role of titin, a giant muscle protein, in the progression of epithelial ovarian cancer (EOC). We examined titin levels in tissues and sera from EOC patients across stages I–IV and in chemoresistant EOC cells.
Harvey Sharma +10 more
doaj +1 more source
Stretching of Proteins in the Entropic Limit [PDF]
, 2003 Mechanical stretching of six proteins is studied through molecular dynamics simulations. The model is Go-like, with Lennard-Jones interactions at native contacts.
Cieplak, Marek +2 more
core +1 more source
Sudden cardiac death in young athletes: Literature review of molecular basis [PDF]
, 2020 Intense athletic training and competition can rarely result in sudden cardiac death (SCD). Despite the introduction of pre-participation cardiovascular screening, especially among young competitive athletes, sport-related SCD remains a debated issue ...
Barbara Lombardo +5 more
core +1 more source
Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
Nature Communications, 2020 The giant protein titin is thought to be required for sarcomeric integrity in mature myocytes, but direct evidence for this hypothesis is limited.
Sandra Swist +9 more
semanticscholar +1 more source
Titin N2A Domain and Its Interactions at the Sarcomere
International Journal of Molecular Sciences, 2021 Titin is a giant protein in the sarcomere that plays an essential role in muscle contraction with actin and myosin filaments. However, its utility goes beyond mechanical functions, extending to versatile and complex roles in sarcomere organization and ...
Adeleye O Adewale, Y. Ahn
semanticscholar +1 more source
An Ising-Like model for protein mechanical unfolding
, 2007 The mechanical unfolding of proteins is investigated by extending the Wako-Saito-Munoz-Eaton model, a simplified protein model with binary degrees of freedom, which has proved successful in describing the kinetics of protein folding.
A. Imparato +7 more
core +1 more source
Lower Limb Radiology of Distal Myopathy due to the S60F Myotilin Mutation [PDF]
, 2009 Distal myopathies are a clinically and genetically heterogenous group of disorders in which the distal limb musculature is selectively or disproportionately affected.
Birchall, Daniel +8 more
core +1 more source
Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants.
Circulation, 2019 Truncating variants in the Titin gene (TTNtvs) are common in individuals with idiopathic dilated cardiomyopathy (DCM). However, a comprehensive genomics-first evaluation of the impact of TTNtvs in different clinical contexts, and the evaluation of ...
C. Haggerty +38 more
semanticscholar +1 more source