Results 11 to 20 of about 11,832,408 (324)

Immunohistochemical Expression of TLR-4 in Temporomandibular Joint Dysfunction [PDF]

CRANIO®, 2018
Objective Toll-like receptor 4 (TLR-4) is a transmembrane protein involved in the innate immune system and has been implicated in the pathogenesis of temporomandibular joint dysfunction (TMD).
Almeida, Luis Eduardo, Bosio, Jose A, Butcher, Seth, Camejo, Flavio, Doetzer, Andrea, Hresko, Kyle, Leonardi, Rosalia, Loreto, Carla, Sorenson, Adam, Tayebi, Lobat   +9 more
core   +5 more sources

Lipopolysaccharide- TLR-4 Axis regulates Osteoclastogenesis independent of RANKL/RANK signaling [PDF]

BMC Immunology, 2021
Background Lipopolysaccharide (LPS) is an endotoxin and a vital component of gram-negative bacteria’s outer membrane. During gram-negative bacterial sepsis, LPS regulates osteoclast differentiation and activity, in addition to increasing inflammation ...
Mohammed S. AlQranei, Linda T. Senbanjo, H. Aljohani, Therwa Hamza, M. Chellaiah   +4 more
semanticscholar   +4 more sources

The role of TLR-4 in chemoresistance of cancer. [PDF]

Discov Oncol
Abstract Chemotherapy, which aims to eradicate tumor cells and enhance patient survival, is a prevalent approach for tumor treatment. Nevertheless, recurrence and drug resistance resulting from consecutive chemotherapy regimens have emerged as significant factors contributing to the high fatality rates among cancer patients.
Li Y, Tang T, Sun Y, Chen G, Yuan X, Cai.   +5 more
europepmc   +4 more sources

Influence of genetic variability in toll-like receptors (TLR 2, TLR 4, and TLR 9) on human immunodeficiency virus-1 disease progression

International Journal of Mycobacteriology, 2023
Background: It has been demonstrated that toll-like receptors (TLR2), TLR4, and TLR9 which were initially known for recognizing bacterial products are involved in the detection of viral components.
Gaurav Kaushik, Richa Vashishtha
doaj   +1 more source

Acute Inflammation Is a Predisposing Factor for Weight Gain and Insulin Resistance

Pharmaceutics, 2022
In the course of infection and intense endotoxemia processes, induction of a catabolic state leading to weight loss is observed in mice and humans. However, the late effects of acute inflammation on energy homeostasis, regulation of body weight and ...
Edson Mendes de Oliveira, Jacqueline C. Silva, Thais P. Ascar, Silvana Sandri, Alexandre F. Marchi, Silene Migliorini, Helder T. I. Nakaya, Ricardo A. Fock, Ana Campa   +8 more
doaj   +1 more source

Subcellular organelle lipidomics in TLR-4-activated macrophages [PDF]

Journal of Lipid Research, 2010
Lipids orchestrate biological processes by acting remotely as signaling molecules or locally as membrane components that modulate protein function. Detailed insight into lipid function requires knowledge of the subcellular localization of individual lipids.
Alexander Y, Andreyev, Eoin, Fahy, Ziqiang, Guan, Samuel, Kelly, Xiang, Li, Jeffrey G, McDonald, Stephen, Milne, David, Myers, Hyejung, Park, Andrea, Ryan, Bonne M, Thompson, Elaine, Wang, Yihua, Zhao, H Alex, Brown, Alfred H, Merrill, Christian R H, Raetz, David W, Russell, Shankar, Subramaniam, Edward A, Dennis   +18 more
openaire   +2 more sources

Sophoricoside attenuates neuronal injury and altered cognitive function by regulating the LTR-4/NF-κB/PI3K signalling pathway in anaesthetic-exposed neonatal rats

Archives of Medical Science, 2020
Introduction This study examined the protective effects of sophoricoside on neuronal injury and cognitive dysfunction in anaesthetic-exposed neonatal rats.
Lihua Yang, Yucan Xu, Wei Zhang
doaj   +1 more source

Non-toxic sulfur inhibits LPS-induced inflammation by regulating TLR-4 and JAK2/STAT3 through IL-6 signaling

Molecular Medicine Reports, 2021
Janus kinase 2 (JAK2) and STAT3 signaling is considered a major pathway in lipopolysaccharide (LPS)-induced inflammation. Toll-like receptor 4 (TLR-4) is an inflammatory response receptor that activates JAK2 during inflammation.
D. Y. Kang, Nipin Sp, E. Jo, Alexis Rugamba, H. Kim, Il Ho Kim, Jong-Chan Park, S. Bae, Kyoung-Jin Jang, Y. Yang   +9 more
semanticscholar   +1 more source

Salidroside alleviates hepatic ischemia–reperfusion injury during liver transplant in rat through regulating TLR-4/NF-κB/NLRP3 inflammatory pathway

Scientific Reports, 2022
Salidroside has anti-inflammatory, antioxidant and hepatoprotective properties. However, its effect on hepatic ischemia–reperfusion injury (IRI), an unavoidable side effect associated with liver transplantation, remains undefined.
Yanyao Liu, Z. Lei, Hao Chai, Q. Kang, Xiaoyan Qin   +4 more
semanticscholar   +1 more source

Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4 [PDF]

Molecular Neurobiology, 2018
Diabetes increases the risk of occurrence and poor functional recovery after ischemic stroke injury. Previously, we have demonstrated greater hemorrhagic transformation (HT), edema, and more severe functional deficits after stroke in diabetic animals that also presented with cerebral vasoregression and endothelial cell death in the recovery period ...
Yasir Abdul, M. Abdelsaid, Weiguo Li, R. Webb, Jennifer C. Sullivan, Guangkuo Dong, A. Ergul   +6 more
semanticscholar   +3 more sources