Results 31 to 40 of about 11,832,408 (324)

Aggregatibacter actinomycetemcomitans modulates toll-like receptors 2 and 4 in gingival epithelial cells in experimental periodontitis

Journal of International Clinical Dental Research Organization, 2010
Background: Periodontitis is a common bacterial infection precipitated by exaggerated host responses to the oral microorganisms, As the first cells to encounter the oral pathogens the gingival epithelial cells (GEC) respond via toll-like receptors (TLR ...
Mythily Srinivasan, Krithika N Kodumudi, Dominique M Galli   +2 more
doaj   +1 more source

Effects of empagliflozin on a model of chronic depression and brain Toll-like receptors gene expression in male rats

Medical Journal of Babylon, 2023
Background: Empagliflozin is an antidiabetic medication having anti-inflammatory and antioxidant properties. Objectives: To develop a chronic unpredictable stress (CUS) model in male rats, evaluate empagliflozin’s antidepressant effects, and describe the
Hatem Kareem Mijwel, Salman M Salman, Alaa H Al-Charrakh   +2 more
doaj   +1 more source

TLR‐2 and TLR‐4 expression in monocytes of newborns with late‐onset sepsis

Jornal de Pediatria (Versão em Português), 2014
Objective: To analyze toll‐like receptor (TLR)‐2 and TLR‐4 expression in monocytes of newborns with late‐onset sepsis. Methods: This prospective study included 27 full‐term newborns aged 8 to 29 days, with clinical and laboratory diagnosis of late‐onset ...
Ana C.C. Redondo, Maria E.J.R. Ceccon, Ana L. Silveira‐Lessa, Camila Quinello, Patrícia Palmeira, Werther B. Carvalho, Magda Carneiro‐Sampaio   +6 more
doaj   +1 more source

TLR-4 Signaling vs. Immune Checkpoints, miRNAs Molecules, Cancer Stem Cells, and Wingless-Signaling Interplay in Glioblastoma Multiforme—Future Perspectives

International Journal of Molecular Sciences, 2020
Toll-like-receptor (TLR) family members were detected in the central nervous system (CNS). TLR occurrence was noticed and widely described in glioblastomamultiforme (GBM) cells. After ligand attachment, TLR-4 reorients domains and dimerizes, activates an
J. Litak, C. Grochowski, Joanna Litak, Ida Osuchowska, Krzysztof Gosik, E. Radzikowska, P. Kamieniak, J. Roliński   +7 more
semanticscholar   +1 more source

Expression of TLR-4 and -2 in peripheral mononuclear cells in renal transplant patients with TLR-4 gene polymorphism

International Immunopharmacology, 2010
TLR-4 has also been identified as a receptor for endogenous alarmins, which are increased post transplantation. TLR-4 has also been associated with a polymorphism that could impact graft outcome.To assess the expression of TLR-4 in kidney transplant patients carrying or not a polymorphism.TLR-4 polymorphism (A299G/T399I) was studied in 200 renal ...
Nogueira, Eliana UNIFESP, Salomao, Reinaldo UNIFESP, Collo Brunialti, Milena Karina UNIFESP, Ozaki, Kikumi S., Marques, Georgia D. M., Cenedeze, Marcos A., Saraiva Camara, Niels Olsen, Pacheco-Silva, Alvaro   +7 more
openaire   +3 more sources

Single nucleotide polymorphisms of TLR-2, TLR-3, TLR-4 and susceptibility to inflammatory diseases of the respiratory tract

Zaporožskij Medicinskij Žurnal, 2018
The aim of the research is to establish an association between Arg753Gln polymorphism of TLR-2 gene, Leu412Phe of TLR-3 gene, Asp299Gly of TLR-4 gene and susceptibility to inflammatory diseases of the upper and lower respiratory tract and the complicated
N. O. Pryimenko, T. M. Kotelevska, H. M. Dubynska, I. P. Kaidashev, K. V. Pikul   +4 more
doaj   +1 more source

Zoledronic acid promotes TLR‐4‐mediated M1 macrophage polarization in bisphosphonate‐related osteonecrosis of the jaw

The FASEB Journal, 2019
Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is a detrimental side effect of the long‐term administration of bisphosphonates. Although macrophages were reported to be an important mediator of BRONJ, the detailed potential mechanism of BRONJ ...
Weiwen Zhu, Rongyao Xu, Jinying Du, Yu Fu, Sheng Li, Ping Zhang, Laikui Liu, Hongbing Jiang   +7 more
semanticscholar   +1 more source

Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway

Drug Design, Development and Therapy, 2019
Purpose It has been reported that approximately 40% of ALI (acute lung injury) incidence resulted from sepsis. Paclitaxel, as a classic anti-cancer drug, plays an important role in the regulation of inflammation.
Yuming Wang, R. Ji, Weiwei Chen, Shun-wei Huang, Yan-Jun Zheng, Zhitao Yang, Hong-ping Qu, Hao Chen, E. Mao, Ying Chen, E. Chen   +10 more
semanticscholar   +1 more source

The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease [PDF]

, 2010
The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood ...
Al-Riyami, Al-Riyammi, Aoyama, Baev, Bashir, Bogoyevitch, Borghouts, Bowdish, Bowdish, Bradley, Brattig, Burke, Burke, Burke, Busse, Calpe, Choubey, Clutter, Cooper, Couper, Croese, Dagia, Deehan, Diaz, Dittrich, Divangahi, Elliott, Elliott, Elliott, Everts, Fabriek, Falcone, Fulkerson, Goodridge, Goodridge, Goodridge, Goodridge, Goodridge, Gu, Hamerman, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, He, Houston, Hunter, Ishibashi, Jayapal, Johnson, Kakinuma, Katschke, Kean, Khan, Kim, King, Kitagaki, Kuroki, Lai, Lai, Lamb, Lubberts, Maizels, Mansoor, Marshall, Maurer, McInnes, McInnes, Melendez, Mendoza, Mi, Mori, Moriyama, Moriyama, Moriyama, Nagel-Wolfrum, Node, Page, Polfliet, Pushparaj, Pushparaj, Rajan, Reddy, Rioja, Rogers, Satoh, Saunders, Schnoeller, Schramm, Schramm, Steinfelder, Strickland, Subramanian, Suciu-Foca, Thalhamer, Thomas, Tilstra, van Riet, Wang, Wang, WHO, Wills-Karp, Wilson, Wohlleben, Wong, Wray, Zaccone   +111 more
core   +2 more sources

Nitric oxide boosts TLR‐4 mediated lipocalin 2 expression in chondrocytes [PDF]

Journal of Orthopaedic Research, 2013
AbstractLipocalin 2 (LCN2) has recently emerged as a novel adipokine involved in different processes including arthritis and chondrocyte inflammatory response. However, little is known about its activity on chondrocyte homeostasis and its regulation by nitric oxide (NO) Hence, we performed a set of experiments aimed to achieve a better understanding of
Gómez Bahamonde, Rodolfo, Scotece, M, Conde Aranda, Javier, López López, Verónica, Pino Mínguez, Jesús, Lago Paz, Francisca, Gómez-Reino Carnota, Juan Jesús, Gualillo ., Oreste   +7 more
openaire   +3 more sources