Results 41 to 50 of about 11,832,408 (324)

Effects of probiotic feed additives (biosol and Zemos) on growth and related genes in broiler chickens

Italian Journal of Animal Science, 2022
The goal of this study was to look into the effect of two probiotics as feed additives: Biosol (lipotropic factor containing probiotics) and/or Zemos, and to determine the best regimen for using both probiotics to improve growth performance, carcass ...
Nessma Hassan, Ismail Mostafa, Mohamed A. Elhady, Marwa A. Ibrahim, Hassan Amer   +4 more
doaj   +1 more source

The Distinctive Activation of Toll-Like Receptor 4 in Human Samples with Sepsis

Cells, 2022
Clinical success of Toll-Like receptor-4 (TLR-4) antagonists in sepsis therapy has thus far been lacking. As inhibition of a receptor can only be useful if the receptor is active, stratification of patients with active TLR-4 would be desirable.
Patrick Thon, Katharina Rump, Annika Knorr, Birte Dyck, Dominik Ziehe, Matthias Unterberg, Hartmuth Nowak, Lars Bergmann, Alexander Wolf, Maha Bazzi, Jennifer Orlowski, Marcus Peters, Alexander Zarbock, Thorsten Brenner, Michael Adamzik, Tim Rahmel, Björn Koos   +16 more
doaj   +1 more source

Artesunate provides Neuroprotection Against Cerebral Ischemia/Reperfusion Injury via the TLR-4/NF-κB Pathway in Rats.

Biological and Pharmaceutical Bulletin, 2020
Inflammation has an important role in ischemia/reperfusion (I/R) injury. Artesunate (ART) has anti-microbial and anti-inflammatory pharmacological activities, and it is used for various types of serious malaria, including cerebral malaria.
Yanlin Chen, Jingxian Wu, Jin Zhu, Guoan Yang, Junying Tian, Yong Zhao, Yili Wang   +6 more
semanticscholar   +1 more source

Polysaccharides from Dicliptera chinensis ameliorate liver disturbance by regulating TLR‐4/NF‐κB and AMPK/Nrf2 signalling pathways

Journal of Cellular and Molecular Medicine, 2020
The purpose of this study was to alleviate liver disturbance by applying polysaccharides from Dicliptera chinensis (DCP) to act on the adenosine monophosphate–activated protein kinase/ nuclear factor erythroid 2‐related factor 2 (AMPK/ Nrf2) oxidative ...
Kefeng Zhang, Qiongmei Xu, Ya Gao, Houkang Cao, Yuanyu Lian, Zimeng Li, Jie Xu, Mingli Zhong, Jiani Li, R. Wei, Jianghui Dong, Ling Jin   +11 more
semanticscholar   +1 more source

Prothymosin a and a prothymosin α-derived peptide enhance TH1-type immune responses against defined HER-2/neu epitopes [PDF]

, 2013
Background: Active cancer immunotherapies are beginning to yield clinical benefit, especially those using peptide-pulsed dendritic cells (DCs). Different adjuvants, including Toll-like receptor (TLR) agonists, commonly co-administered to cancer patients ...
Derhovanessian, Evelyna, Ioannou, Kyriaki, Kalbacher, Hubert, Pawelec, Graham, Samara, Pinelopi, Trougakos, Ioannis P., Tsakiri, Eleni, Tsitsilonis, Ourania E., Voelter, Wolfgang   +8 more
core   +1 more source

CD14+ CD15- HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure. [PDF]

, 2017
OBJECTIVE: Immune paresis in patients with acute-on-chronic liver failure (ACLF) accounts for infection susceptibility and increased mortality. Immunosuppressive mononuclear CD14+HLA-DR- myeloid-derived suppressor cells (M-MDSCs) have recently been ...
Adams, DH, Antoniades, CG, Bernsmeier, C, Brenig, R, Khamri, W, Lebosse, FJ, Nathwani, R, Patel, VC, Pop, OT, Singanayagam, A, Thursz, MR, Tidswell, R, Triantafyllou, E, Wendon, JA, Weston, CJ   +14 more
core   +2 more sources

Effects of lime (Citrus aurantifolia) peel to the expression of mRNA toll-like receptors 4 in balb/c mice-infected Salmonella typhi

Journal of Advanced Pharmaceutical Technology & Research, 2020
Lime peel contains metabolic compounds that have lethal effects of bacterial cells, but its effect as an antibacterial modulate innate immunity pathways, especially toll-like receptor 4 (TLR-4) signaling pathway, is unclear.
Vivien Novarina Kasim, Mochammad Hatta, Rosdiana Natzir, Veni Hadju, Ami Febriza, Hasta Handayani Idrus   +5 more
doaj   +1 more source

Evaluation of Toll-Like receptor 2 and 4 RNA expression and the cytokine profile in postmenopausal women with metabolic syndrome. [PDF]

PLoS ONE, 2014
OBJECTIVE: To evaluate the gene expression of Toll-Like (TLR-2 and TLR-4) receptors and cytokine profile in postmenopausal women with or without metabolic syndrome (MetS).
Claudio Lera Orsatti, Eliana Aguiar Petri Nahas, Jorge Nahas-Neto, Fabio Lera Orsatti, Vanessa Innocenti Giorgi, Steven S Witkin   +5 more
doaj   +1 more source

Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis

Frontiers in Pharmacology, 2020
Liver ischemia-reperfusion injury (IRI) is a common clinical event with high morbidity in patients undergoing complex liver surgery or having abdominal trauma.
Shilong Zhang, Zanjie Feng, Weidong Gao, Yuling Duan, Guoxin Fan, X. Geng, Bo Wu, Kai Li, Kangwei Liu, Cijun Peng   +9 more
semanticscholar   +1 more source

TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis [PDF]

, 2012
Background Experimental autoimmune encephalomyelitis (EAE) depends on the initial activation of CD4+ T cells responsive to myelin autoantigens. The key antigen presenting cell (APC) population that drives the activation of naïve T cells most efficiently ...
AC Buenafe, Andrew S MacDonald, AS MacDonald, Bernd Arnold, BM Segal, BN Dittel, C Sutton, CR Weir, Darryl G Turner, DJ Cua, F Petermann, FC Kurschus, Florian C Kurschus, G Perona-Wright, GY Liu, Helen Cambrook, JT Tigno-Aranjuez, K Hochweller, KR Ryan, L Visser, Melanie D Leech, N Aghdami, NA Wolf, PJ Fairchild, Richard A O’Connor, Richard J Mellanby, RM Steinman, SM Anderton, SM Kerfoot, Stephen M Anderton, V Lampropoulou, V Lampropoulou, Y Bulut, Y Okuda   +33 more
core   +2 more sources