LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease [PDF]
, 2015 Lipopolysaccharide (LPS) is currently considered one of the major players in non-alcoholic fatty liver disease (NAFLD) pathogenesis and progression.
Agostinelli, Laura +16 more
core +2 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
The Effect of TLR4 Asp299Gly polymorphism on IL-6 and IL -18 expression in H.pylori infected patients [PDF]
Journal of Kerman University of Medical Sciences, 2016 Background & Aims: Helicobacter pylori (H. pylori) infection is associated with peptic ulcer and gastric cancer. Polymorphisms of the genes coding Toll-like receptors (TLRs) may influence the innate and adaptive immune responses and affect the ...
Ghorbanali Rahimian +3 more
doaj
Evaluation of the constitutive expression levels of ch-TLR 3, ch-TLR 4, ch-TLR 15 and ch-TLR 21 genes in the Peripheral Blood Mononuclear Cells of native Indian poultry breeds, Aseel and Kadaknath [PDF]
Veterinary World, 2013 Aim: To assess the basal constitutive expression levels of ch-TLR3, ch-TLR 4, ch-TLR 15 and ch-TLR 21 in the peripheral blood mononuclear cells (PBMCs) in Aseel and Kadaknath chicks (Indian native poultry breeds) and to evaluate the differences in their ...
H. C. Chauhan +7 more
doaj +1 more source
Cellular actors, Toll-like receptors, and local cytokine profile in acute coronary syndromes [PDF]
, 2017 Aims Inflammation plays a key role in acute coronary syndromes (ACS). Toll-like receptors (TLR) on leucocytes mediate inflammation and immune responses.
Altwegg, Lukas +14 more
core
Mycobacterium tuberculosis multi-drug-resistant strain M induces IL-17+ IFNγ- CD4+ T cell expansion through an IL-23 and TGF-β-dependent mechanism in patients with MDR-TB tuberculosis [PDF]
, 2016 We have previously reported that T cells from patients with multidrug-resistant tuberculosis (MDR-TB) express high levels of IL-17 in response to the MDR strain M(Haarlem family) of Mycobacterium tuberculosis (M.tuberculosis).
Balboa, Luciana +13 more
core +2 more sources
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Synthetic Toll like receptor-4 (TLR-4) agonist peptides as a novel class of adjuvants. [PDF]
PLoS ONE, 2012 Adjuvants serve as catalysts of the innate immune response by initiating a localized site of inflammation that is mitigated by the interactions between antigens and toll like receptor (TLR) proteins.
Arulkumaran Shanmugam +5 more
doaj +1 more source
PLoS ONE, 2018 Countless neurodegenerative diseases are associated with perverse multiple targets of cyclic nucleotide signalling, hastening neuronal death. Cilostazol, a phosphodiesterase-III inhibitor, exerts neuroprotective effects against sundry models of ...
H. El-Abhar +3 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin +11 more
wiley +1 more source