Results 151 to 160 of about 133,056 (344)
Animal Research and One Health, EarlyView.Multi‐omics analysis revealed that FOS supplementation increased the abundance of Phascolarctobacterium, GCA‐900066575, Shuttleworthia, Olsenella, Eubacterium_hallii_group while decreasing Alistipes. It also influenced the metabolism of S‐lactoylglutathione, p‐cresol glucuronate, 2‐phenylethanol glucuronide, propionic acid, dulcitol, and inhibited the ...
Dan Song +11 more
wiley +1 more source
Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway
PLOS Pathogens, 2015 Human Cytomegalovirus (HCMV) encodes multiple microRNAs (miRNAs) whose functions are just beginning to be uncovered. Using in silico approaches, we identified the Toll-Like Receptor (TLR) innate immunity pathway as a possible target of HCMV miRNAs. Luciferase reporter assay screens further identified TLR2 as a target of HCMV miR-UL112-3p.
Daniel N. Streblow +5 more
openaire +5 more sources
Infection and Drug Resistance, 2019 Zhiyong Wu,1,* Chunli Chen,1,* Yusong Miao,1 Yuhao Liu,1 Qiaomei Zhang,1 Rui Li,1 Liangjun Ding,1 Muhammad Ishfaq,1 Jichang Li1,2 1College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, People’s Republic of China ...
Wu Z +8 more
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Arthritis Research & Therapy, 2016 BackgroundSynovial infiltration of monocytes is commonly associated with inflammation in rheumatoid arthritis (RA). Toll-like receptors (TLRs) are innate sensors that recognize cell debris and microbial components in host, a process contributing to ...
Patricia Lacerte +5 more
semanticscholar +1 more source
Antiphospholipid Syndrome: An Antibody‐Mediated Disease With Emerging Therapeutic Opportunities
Arthritis &Rheumatology, EarlyView.Antiphospholipid syndrome (APS) is an autoimmune thromboinflammatory disease characterized by vascular thrombosis, pregnancy morbidity, and other manifestations driven by antiphospholipid autoantibodies. In this review, we present a clinical case that illustrates some diagnostic and therapeutic challenges in managing severe, relapsing APS ...
Thalia G. Newman, Jason S. Knight
wiley +1 more source
Active Components of Leptospira Outer Membrane Protein LipL32 to Toll-Like Receptor 2
Scientific Reports, 2017 Proteins belonging to the toll-like receptor (TLR) family, particularly TLR2, are the major components of innate immunity against Leptospira infection.
Shen-Hsing Hsu +10 more
doaj +1 more source
Systemic TLR2 tolerance enhances central nervous system remyelination
Journal of Neuroinflammation, 2019 Background Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by both inflammatory demyelination and impaired remyelination.
Nicholas J. Wasko +9 more
doaj +1 more source
PLoS ONE, 2017 Toll-like receptors (TLRs) 2 and 4 play critical roles in intestinal inflammation caused by Fusobacterium nucleatum (F. nucleatum) infection, but the role of TLR2/TLR4 in regulation of proinflammatory cytokines remains unknown.
Yin-ping Jia +9 more
semanticscholar +1 more source
From Genome to Geroscience: How DNA Damage Shapes Systemic Decline
BioEssays, EarlyView.Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley +1 more source
Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019 Receptorii Toll-like recunosc structurile moleculare legate de agentul patogen a micobacterii și, astfel, joacă un rol important în protecţia organismului faţă de infecţia tuberculoasă.
Alexandru Varzari +5 more
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