Results 191 to 200 of about 19,241 (251)

Extracellular high mobility group box 1 as a UV‐induced alarmin driving cutaneous inflammation and photoaging via TLR4 signaling

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
UV irradiation triggers the active release of HMGB1 from skin cell nuclei into the extracellular space. Extracellular HMGB1 binds TLR4 receptors on neighboring cells, initiating a signaling cascade that upregulates proinflammatory cytokines (IL‐1β, IL‐6, IL‐8, and TNF‐α). This chronic inflammatory state drives neutrophil infiltration and collagen fiber
Qian Liufu, Zhaoping Qin, Yan Yan, Yiru Xu, Tianyuan He, Yingchun Liu, Yaping Xiang, Chunfang Guo, Taihao Quan   +8 more
wiley   +1 more source

Mechanistic Insights Into the Association Between Gut Microbiota Diversity and Atherosclerosis, Acute Coronary Syndrome, and Peripheral Arterial Disease Progression

Clinical Cardiology, Volume 49, Issue 9, September 2026.
Proposed gut‐vascular framework linking microbial ecology to atherosclerotic disease. Diet and related exposures shape dysbiosis or microbial resilience; resulting changes in SCFAs, TMAO, bile acids, and LPS may modulate endothelial function, immune activation, and platelet activity, contributing to atherosclerosis, ACS, and PAD.
Amr Ali Mohamed Abdelgawwad El‐Sehrawy, Usamah Sayed, Zarina Nasirova, Quvonch Tursunov, Omer Qutaiba B. Allela, Lara Asim Kzar, Rajashree Panigrahi, Neeraj Bainsal   +7 more
wiley   +1 more source

Lactoferrin and Nanotechnology: New Insights Into Glioblastoma Therapy

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Current glioblastoma multiforme (GBM) management primarily relies on surgery, chemotherapy, and radiotherapy; however, therapeutic efficacy remains limited due to tumor invasiveness and restricted drug penetration across the blood–brain barrier. Lactoferrin (LF), an iron‐binding glycoprotein with receptor‐mediated transport capability, has emerged as a
Atena Abed, Javad Amini Mahabadi
wiley   +1 more source

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Evolutionary Response Patterns of the Rodent TLR Genes to Climatic Factors

Ecology and Evolution, Volume 16, Issue 9, September 2026.
This study systematically investigates the associations between climatic factors and the evolutionary dynamics of Toll‐like receptor (TLR) genes across 42 rodent species. Our findings demonstrate that temperature‐related climatic variables (Annual Mean Temperature, Mean Diurnal Range, and Max Temperature of Warmest Month) may modulate the evolutionary ...
Chao Zhao, Tian Xia, Guangshuai Liu, Zhao Liu, Xinglei Ding, Shuo Dai, Honghai Zhang   +6 more
wiley   +1 more source

Synthetic Food Colorants and Gut Microbiota: A Systematic Review of Preclinical Studies

Food Frontiers, Volume 7, Issue 5, September 2026.
ABSTRACT Growing evidence suggests that industrial food processing, including the excess consumption of food additives, might have a negative impact on human health. Despite regulatory safety evaluations, their impact on gut microbiota remains poorly characterized.
Sebastiano Alfio Torrisi, Federica Martina Di Domenico, Gian Marco Leggio, Giuseppe Caruso, Evelyn Frias‐Toral, Nohora Milena Martínez López, Agnieszka Micek, Marialaura Bonaccio, Justyna Godos, Giuseppe Grosso   +9 more
wiley   +1 more source

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, Volume 3, Issue 3, September 2026.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, Volume 2, Issue 3, September 2026.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, Volume 2, Issue 3, September 2026.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Host‐to‐Pathogen Transfer of Neutrophil Components via Extracellular Vesicles Shields Candida albicans From Immune Attack in Human Blood

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Neutrophils release extracellular vesicles (EVs) in response to Candida albicans, and these EVs bind to the fungus in a complement‐dependent manner while carrying neutrophil surface markers and antimicrobial proteins. Despite this cargo, EV coating does not inhibit fungal growth but markedly reduces neutrophil phagocytic uptake in purified‐cell assays ...
Jennifer J. Patitz, Natalie E. Nieuwenhuizen, Anastasia Solomatina, Yann Bachelot, Thomas Krüger, Carl‐Magnus Svensson, Stephanie Hoeppener, Ann‐Kathrin Zimmermann, Matthew G. Blango, Ronny Martin, Olaf Kniemeyer, Theresa Lange, Axel A. Brakhage, Marc Thilo Figge, Oliver Kurzai, Kerstin Hünniger‐Ast   +15 more
wiley   +1 more source