Ginsenoside Rg1 attenuates experimental periodontitis via modulating the PI3K/AKT pathway and TLR2 expression. [PDF]
BMC Oral HealthPu Y, Chen L, Wang D, Pan Y, Guo L.
europepmc +1 more source
Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives
MedComm – Oncology, Volume 5, Issue 2, June 2026.Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang +14 more
wiley +1 more source
Development and internal validation of a TLR2-based nomogram for diagnosing pulmonary infection in type 2 diabetes. [PDF]
Front Endocrinol (Lausanne)Ma Y, Qin F.
europepmc +1 more source
The Journal of Pathology, Volume 269, Issue 2, Page 232-247, June 2026.Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada +8 more
wiley +1 more source
FomA-Containing Outer Membrane Vesicles of Fusobacterium Nucleatum Facilitate Bladder Cancer Lymphatic Metastasis via IL-6-Dependent M2b Macrophage Polarization. [PDF]
Adv Sci (Weinh)Shangguan W +17 more
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The Role of Inflammation in Infant Colic—A Systematic Review and Meta‐Analysis
Acta Paediatrica, Volume 115, Issue 6, Page 1158-1169, June 2026.ABSTRACT Aim Despite being a self‐limiting condition, infant colic is associated with negative consequences for caregivers and infants. Gut inflammation is hypothesised as a contributing factor. We collected and meta‐analysed the most recent evidence on the association between infant colic and gut inflammation.
Dan Boëtius Andersen +8 more
wiley +1 more source
Identification of key genes and metabolites in acute ischemic stroke via integrated transcriptomic and metabolomic analysis. [PDF]
Front NeurolZhang J, Zhou X, He D.
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Immune endotypes in tuberculosis: Keys to decoding disease complexity
Journal of Internal Medicine, Volume 299, Issue 6, Page 670-693, June 2026.Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Shamila D. Alipoor +4 more
wiley +1 more source
Bisarylthiourea comprising cycloalkyl-thiophene-3-carboxylate derivatives as potential human toll-like receptor (TLR2) agonists: design, synthesis, and structure-activity relationship enabling the switch from TLR2/1 to TLR2/6 activation. [PDF]
RSC Med ChemChandrakanth M +5 more
europepmc +1 more source
The FASEB Journal, Volume 40, Issue 9, 15 May 2026.Simvastatin synergizes with cisplatin in cisplatin‐resistant cervical cancer cells through suppression of the caveolin‐1‐mediated PI3K/AKT signaling axis. ABSTRACT Cervical cancer treatment is often hindered by the emergence of cisplatin (DDP) resistance. Increasing evidence has indicated that statins possess anti‐tumor and chemosensitization potential
Yujia Zhou +7 more
wiley +1 more source