Results 211 to 220 of about 19,241 (251)
Neuroprotection, Volume 4, Issue 3, Page 213-228, September 2026.ECM, extracellular matrix; BDNF, brain‐derived neuroptrophic factor; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor. Abstract Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and ...
Mozammel H. Bhuiyan +3 more
wiley +1 more source
Akkermansia muciniphila and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging
Aging Cell, Volume 25, Issue 9, September 2026.The beneficial gut bacterium Akkermansia muciniphila (AKK) declines with age but is enriched in healthy centenarians. Supplementation of AKK extends healthspan and alleviates age‐related decline through direct host–microbe interactions and its bioactive derivatives, which collectively enhance gut barrier integrity, restore metabolic homeostasis ...
Ting Zhang +7 more
wiley +1 more source
Alcohol, Clinical and Experimental Research, Volume 50, Issue 9, September 2026.PAE creates a unique inflammatory signature in the mature adult brain with region‐specific changes in genes implicated in glial‐immune function. We report at least 60 differentially expressed genes in different brain regions due to PAE, many of which are associated with neuroimmune function.
Alissa N. Jones +6 more
wiley +1 more source
Phloretin as a Potent Natural TLR2/1 Inhibitor Suppresses TLR2-Induced Inflammation [PDF]
Nutrients, 2018 Toll-like receptor 2 (TLR2) responses are involved in various inflammatory immune disorders. Phloretin is a naturally occurring dietary flavonoid that is abundant in fruit.
Yangmee Kim +2 more
exaly +4 more sources
The Role of TLR2 in Infection and Immunity [PDF]
Frontiers in Immunology, 2012 Toll-like receptors (TLRs) are recognition molecules for multiple pathogens, including bacteria, viruses, fungi, and parasites. TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae ...
Lee Wetzler, Paola Massari
exaly +4 more sources
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Science Signaling, 2021
TLR2 located in the endothelium promotes angiogenesis and inflammation.
Samantha Mahfoud, Tatiana V. Petrova
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TLR2 located in the endothelium promotes angiogenesis and inflammation.
Samantha Mahfoud, Tatiana V. Petrova
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TLR2 in murine atherosclerosis
Seminars in Immunopathology, 2007Atherosclerosis was once thought to be solely a disease of lipid accumulation in the vessel wall. It does involve lipid accumulation, but inflammation appears to be an important driving factor. Consequently, our laboratory undertook to examine the role(s) of TLRs, and especially TLR2, in murine models of atherosclerosis.
Peter S, Tobias, Linda K, Curtiss
openaire +2 more sources
Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Excess Toll-like receptor 2 (TLR2) signaling has been implicated in numerous inflammatory diseases, yet there is no TLR2 inhibitor licensed for human use. Using computer-aided drug design (CADD), we identified a compound, C 16 H 15
Stefanie Vogel +2 more
exaly +3 more sources
Molecular Genetics, Microbiology and Virology, 2009
Various strains of mycoplasmas cause activation of transcriptional factor NF-kB as a result of interaction with different combinations of Toll-like receptors (TLR). It is well known that the MALP-2 protein of M. fermentans activates the NF-kB through interaction with the TLR2/6, lipid-associated membrane lipopeptides (LAMPs) of M. penetrans through the
D Iu, Logunov +7 more
openaire +2 more sources
Various strains of mycoplasmas cause activation of transcriptional factor NF-kB as a result of interaction with different combinations of Toll-like receptors (TLR). It is well known that the MALP-2 protein of M. fermentans activates the NF-kB through interaction with the TLR2/6, lipid-associated membrane lipopeptides (LAMPs) of M. penetrans through the
D Iu, Logunov +7 more
openaire +2 more sources
The function of TLR2 during staphylococcal diseases [PDF]
Frontiers in Cellular and Infection Microbiology, 2013 Staphylococcus aureus is a versatile pathogen causing a wide range of infections. It has been a major threat both in hospitals and in the community for decades. S. aureus is a pyogenic bacterium that elicits recruitment of polymorphonuclear leukocytes (neutrophils) to the site of infection.
exaly +4 more sources