TLR2 as a Key Mediator: Bergamottin Protects Against Lead-Induced Renal Toxicity by Modulating Oxidative Stress and Pyroptosis Pathways. [PDF]
Food Sci NutrZhu Y, Zhang K, Wen S, Zhang Y.
europepmc +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
TLR agonists as adjuvants for viral vaccines: mechanisms, applications, and future directions. [PDF]
Front MicrobiolShao F +8 more
europepmc +1 more source
Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections
Advanced Science, Volume 13, Issue 3, 14 January 2026.This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin +3 more
wiley +1 more source
Deoxycholic Acid and Lipoteichoic Acid cooperatively drive macrophage M2/M1 polarization via TGR5/STAT3 and TLR2/NF-κB to fuel HCC progression in obesity. [PDF]
Metabol OpenWu J, Zheng W, Ding XZ, Jin QP, Ding MX.
europepmc +1 more source
Advanced Science, Volume 13, Issue 2, 9 January 2026.Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi +4 more
wiley +1 more source
TLR2 agonism suppresses myeloid leukemogenesis by reprogramming leukemia stem cells. [PDF]
Blood AdvLawler ME +6 more
europepmc +1 more source
TLR2 involvement in diabetic nephropathy [PDF]
Nature Reviews Nephrology, 2013 openaire +1 more source
Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy
Advanced Science, Volume 13, Issue 1, 5 January 2026.This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li +5 more
wiley +1 more source