Results 251 to 260 of about 151,127 (263)

Lipid-associated membrane lipopeptides of M. arginini activate NF-κB by interacting with TLR2/1, TLR2/6, and TLR2/CD14

Molecular Genetics, Microbiology and Virology, 2009
Various strains of mycoplasmas cause activation of transcriptional factor NF-kB as a result of interaction with different combinations of Toll-like receptors (TLR). It is well known that the MALP-2 protein of M. fermentans activates the NF-kB through interaction with the TLR2/6, lipid-associated membrane lipopeptides (LAMPs) of M. penetrans through the
D Iu, Logunov, D V, Shchebliakov, O V, Zubkova, M M, Shmarov, I V, Rakovskaia, L A, Gintsburg, A V, Gudkov, B S, Naroditskiĭ   +7 more
openaire   +2 more sources

TLR2 tolerance in EAE

The Journal of Immunology, 2016
Abstract TLR2 expression is enhanced in MS and EAE, but its role in these diseases is controversial. In adoptive transfer EAE, exogenous TLR ligands are not administered yet TLR2-deficient mice have been reported to develop attenuated disease. Despite this evidence for a disease-promoting function of TLR2, others have shown the opposite,
Emily J Anstadt, Mai Fujiwara, Frank Nichols, Robert B Clark   +3 more
openaire   +1 more source

R753Q polymorphism compromises TLR2 signaling functions by altering TLR6-TLR2 hetero-dimerization, TLR2 tyrosine phosphorylation and MyD88 recruitment (180.2)

The Journal of Immunology, 2012
Abstract TLR2 senses lipoproteins expressed by Gram positive bacteria, mycoplasma, mycobacteria and fungi. The Arg753Gln (R753Q) polymorphism in the TIR domain of TLR2 has been linked to increased incidence of tuberculosis, leprosy and other diseases. But the molecular mechanisms by which it affects TLR2 functions are unclear. We studied
Yanbao Xiong, Chang Song, Andrei Medvedev   +2 more
openaire   +1 more source

Megakaryocyte TLR2: immunity bullet?

Blood, 2011
Innate immunity is the host defensive weapon against pathogens and this issue of Blood offers an interesting new bullet for the immune system gun by studying the role of Toll-like receptor 2 (TLR2) in megakaryocytic function; a field previously not explored.
PIGNATELLI, Pasquale, CARNEVALE, Roberto
openaire   +2 more sources

TLR2 Arg677Trp polymorphism in leprosy: revisited

Human Genetics, 2005
We investigated the Toll-like receptor 2 (TLR2) Arg677Trp polymorphism, associated with lepromatous leprosy in the Korean population and shown to abrogate TLR2-mediated signalling in response to mycobacterial ligands, in 286 Indian leprosy patients and 183 ethnically matched controls.
Dheeraj, Malhotra, Vineet, Relhan, B S N, Reddy, Ramesh, Bamezai   +3 more
openaire   +2 more sources

TLR2 joins the interferon gang

Nature Immunology, 2009
The induction of type I interferon is a critical checkpoint in antiviral immunity. Toll-like receptor 2 can unexpectedly induce type I interferon in the subset of inflammatory monocytes during infection with vaccinia virus.
Franz Bauernfeind, Veit Hornung
openaire   +1 more source

TLR2 agonists and their structure–activity relationships

Organic & Biomolecular Chemistry, 2020
We review the structure–activity relationships and synthetic studies of TLR2 agonists – important chemical targets in immunotherapy.
Benjamin L. Lu, Geoffrey M. Williams, Margaret A. Brimble   +2 more
openaire   +2 more sources

The Noninflammatory Side of TLR2

Science Signaling, 2012
Toll-like receptor 2 promotes tumorigenesis in a mouse model of gastric cancer, but not by enhancing inflammation.
openaire   +1 more source

TLR2 Stimulates Th1 Effector Functions

Science's STKE, 2007
Toll-like receptors (TLRs) are pattern-recognition receptors that recognize microbial products and are crucial components of the innate immune system. TLR ligands have costimulatory roles with stimulation of the T cell antigen receptor (TCR) of naïve CD4 + T cells (although TLR ligands alone cannot stimulate naïve
openaire   +1 more source

Does TLR2 regulate intestinal inflammation?

European Journal of Immunology, 2010
AbstractThere is almost no aspect of the immune response that is not regulated by TLR. Initially described as drivers of the innate immune response to pathogens, it is now clear that the TLR family can also influence most aspects of adaptive immunity, as well as determine how tissue cells interact with microbes in their environment.
openaire   +2 more sources