Results 81 to 90 of about 151,127 (263)
Медицина в КузбассеРаботники предприятий черной металлургии подвергаются воздействию промышленных аэрозолей органической и неорганической природы, что может приводить к нарушению механизмов врожденного иммунитета и увеличению частоты респираторных инфекций.
Татьяна Викторовна Бушуева +5 more
doaj +1 more source
Advanced Science, EarlyView.We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin +17 more
wiley +1 more source
Activation of Ca2+-Dependent Signaling by TLR2 [PDF]
The Journal of Immunology, 2006 Abstract Upon contact with airway epithelial cells, bacterial products activate Ca2+ fluxes that are required for induction of NF-κB-dependent gene expression. TLR2 is apically displayed on airway cells, making it a likely transducer linking bacterial stimuli and kinases that affect Ca2+ release. Using biochemical and genetic approaches,
Jarin, Chun, Alice, Prince
openaire +2 more sources
Analysis of TLR2 in Primary Endocrine Resistant of Breast Cancer
Frontiers in Bioscience-LandmarkBackground: Previous clinical studies have suggested that Toll-like receptor (TLR)2 had predictive function for endocrine resistance in HER2-positive breast cancer (BCa).
Yunmei Wang +6 more
doaj +1 more source
Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]
, 2016 Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui +2 more
core +2 more sources
A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat
Advanced Science, EarlyView.An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su +10 more
wiley +1 more source
Leptin up-regulates TLR2 in human monocytes [PDF]
Journal of Leukocyte Biology, 2013 Abstract Leptin-stimulated TLR2 and CD14 expression may potentiate innate immunity and inflammation, in obesity and T2DM. The adipokine leptin elicits changes in the expression of the activation markers CD40 and CD69 in PBMCs and DCs, yet its effect on PRRs remains to be elucidated. Serum leptin concentrations are elevated
Jaedicke KM +5 more
openaire +3 more sources
Gene silencing of Toll-like receptor 2 inhibits proliferation of human liver cancer cells and secretion of inflammatory cytokines. [PDF]
PLoS ONE, 2012 BACKGROUND: Toll-like receptors (TLRs) are key factors in the innate immune system and initiate the inflammatory response to foreign pathogens such as bacteria, fungi and viruses.
Yuzheng Huang +11 more
doaj +1 more source
Cross-disease innate gene signature: Emerging diversity and abundance in RA comparing to SLE and SSc [PDF]
, 2019 Overactivation of the innate immune system together with the impaired downstream pathway of type I interferon-responding genes is a hallmark of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc).
Fillerová, Regina +8 more
core +1 more source
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
Advanced Science, EarlyView.This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source