Results 101 to 110 of about 45,202 (234)

Toll-Like Receptor 3 Is Involved in Detection of Enterovirus A71 Infection and Targeted by Viral 2A Protease

Viruses, 2018
Enterovirus A71 (EV-A71) has emerged as a major pathogen causing hand, foot, and mouth disease, as well as neurological disorders. The host immune response affects the outcomes of EV-A71 infection, leading to either resolution or disease progression ...
Kuan-Ru Chen, Chun-Keung Yu, Szu-Hao Kung, Shun-Hua Chen, Chuan-Fa Chang, Tzu-Chuan Ho, Yi-Ping Lee, Hung-Chuan Chang, Lan-Yin Huang, Shih-Yen Lo, Jui-Chung Chang, Pin Ling   +11 more
doaj   +1 more source

Deletion of Tlr3 reduces acute tolerance to alcohol and alcohol consumption in the intermittent access procedure in male mice

Addiction Biology, 2020
Pharmacological studies implicate toll‐like receptor 3 (TLR3) signaling in alcohol drinking. We examined the role of TLR3 in behavioral responses to alcohol and GABAergic drugs by studying Tlr3 −/− mice.
Y. Blednov, Adriana J Da Costa, Jody Mayfield, R. Harris, R. Messing   +4 more
semanticscholar   +1 more source

MDA5 complements TLR3 in suppression of neuroblastoma

Oncotarget, 2015
Toll-like receptor3 (TLR3) has been confirmed to be differentially expressed in neuroblastoma (NB), and predicts a favorable prognosis with a high expression in tumor tissues. Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral ...
Wen-Ming, Hsu, Chao-Cheng, Huang, Hsin-Yu, Lee, Pei-Yi, Wu, Min-Tsui, Wu, Hui-Ching, Chuang, Li-Ling, Lin, Jiin-Haur, Chuang   +7 more
openaire   +3 more sources

Microbiome‐urothelium crosstalk in bladder cancer: From dysbiosis to clinical translation

iMetaOmics, EarlyView.
This review elucidates the critical crosstalk between the urobiome and bladder cancer (BCa), mapping the landscape from ecological dysbiosis to clinical translation. We synthesize emerging evidence on microbial signatures that distinguish BCa patients, exploring key carcinogenic mechanisms including chronic inflammation, genotoxicity, and the gut ...
Haoxiang Xu, Zhibiao Li, Lin Yang, Jun Zheng, Weijia Li, Rulin Liao, Wenxue Huang, Boyuan Sun, Zhuohang Li, Cunzhen Ma, Xunguo Yang, Zongwei Wang, Jie Zhao, Bisheng Cheng, Peng Wu   +14 more
wiley   +1 more source

Avian Toll-like receptor 3 isoforms and evaluation of Toll-like receptor 3–mediated immune responses using knockout quail fibroblast cells

Poultry Science, 2020
Toll-like receptor 3 (TLR3) induces host innate immune response on recognition of viral double-stranded RNA (dsRNA). Although several studies of avian TLR3 have been reported, none of these studies used a gene knockout (KO) model to directly assess its ...
Mahesh KC, John M. Ngunjiri, Joonbum Lee, Jinsoo Ahn, Mohamed Elaish, Amir Ghorbani, Michael E.C. Abundo, Kichoon Lee, Chang-Won Lee   +8 more
doaj   +1 more source

Profiling the host defense responses against Candida auris in a reliable Drosophila melanogaster infection model

mLife, EarlyView.
Abstract The “superbug” Candida auris has been ranked as a priority fungal pathogen and is becoming a serious threat to public health. However, the underlying mechanisms of real‐world pathogen–host interactions remain elusive, in part due to the lack of powerful immunocompetent animal models.
Jie Li, Guangsheng Chen, Xiangkang Zeng, Jiaxin Lin, Xiaoqing Chen, Wenqiang Wang, Yueru Tian, Xinhua Huang, Yun Zou, Ming Guan, Zhiyi He, Hailei Wang, Changbin Chen, Lei Pan   +13 more
wiley   +1 more source

Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders

Neuroprotection, EarlyView.
The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan, Roshan S. Raghavan, Dawn Li Wei Koh, Wing Yeng Tan, Igor Iezhitsa, Renu Agarwal   +5 more
wiley   +1 more source

TLR3 expression by maternal and fetal cells at the maternal‐fetal interface in normal and preeclamptic pregnancies

Journal of Leukocyte Biology, 2020
Inflammation and oxidative stress at the maternal‐fetal interface characterize the placental dysfunction that underlies the pregnancy disorder preeclampsia.
L. Gierman, G. Silva, Zahra Pervaiz, J. Rakner, S. B. Mundal, A. J. Thaning, I. Nervik, M. Elschot, S. Mathew, L. Thomsen, Line Bjørge, Ann-Charlotte Iversen   +11 more
semanticscholar   +1 more source

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Personalized Cancer Vaccines in the Clinical Trial Pipeline

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This study analyzes the current landscape of personalized cancer vaccine clinical trials, highlighting trends in vaccine platforms, trial phases, and geographic distribution. Peptide and dendritic cell vaccines dominate early‐stage research, with promising immune responses observed in melanoma, glioblastoma, and urothelial cancer trials.
Liudmila Iamukova, Elena Alferova
wiley   +1 more source