Results 71 to 80 of about 45,202 (234)
Toll-like receptors (TLR) 2, 3, and 4 gene polymorphisms in critically ill patients [PDF]
Archives of Biological Sciences, 2015 Considering that TLR2, TLR3 and TLR4 play very important roles in inflammatory processes, the question arises whether the presence of polymorphisms in these genes is associated with susceptibility to sepsis.
Elkilany Atia +5 more
doaj +1 more source
Matrix Stiffness Governs Fibroblasts’ Regulation of Gingival Immune Homeostasis
Advanced Materials, EarlyView.This study identifies a “mechano‐epigenetic” checkpoint in which matrix stiffness governs the immune responses of gingival fibroblasts. Using biomimetic hydrogels and human gingival explants, the studies revealed that restoring extracellular matrix stiffness actively suppresses inflammation via non‐canonical NF‐κB signaling and DNA methylation ...
Hardik Makkar +5 more
wiley +1 more source
Behavioural Brain Research, 2018 HIGHLIGHTSFAAH inhibition attenuates TLR3‐mediated microglia/macrophage activation in the hypothalamus.FAAH inhibition attenuates TLR3‐mediated fever and allodynia, but not hypolocomotion or body weight loss.FAAH inhibition attenuates TLR3‐mediated ...
Lisa E. Flannery +3 more
semanticscholar +1 more source
HIV infection suppresses TLR3 activation‐mediated antiviral immunity in microglia and macrophages
Immunology, 2020 Monocytic‐lineage cells in the central nervous system (CNS), including microglia and brain resident macrophages, are the key players in the CNS innate immunity against viral infections, including human immunodeficiency virus (HIV).
Hang Liu +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang +10 more
wiley +1 more source
Astrocytic Toll-like receptor 3 is associated with ischemic preconditioning-induced protection against brain ischemia in rodents. [PDF]
PLoS ONE, 2014 Cerebral ischemic preconditioning (IPC) protects brain against ischemic injury. Activation of Toll-like receptor 3 (TLR3) signaling can induce neuroprotective mediators, but whether astrocytic TLR3 signaling is involved in IPC-induced ischemic tolerance ...
Lin-na Pan +6 more
doaj +1 more source
TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux
Advanced Science, EarlyView.TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang +14 more
wiley +1 more source
Nature Communications, 2019 Leishmania RNA virus (LRV) is an important virulence factor associated with the development of mucocutaneous Leishmaniasis, a severe form of the disease.
R. V. D. de Carvalho +15 more
semanticscholar +1 more source
Shock waves promote spinal cord repair via TLR3.
JCI Insight, 2020 Spinal cord injury (SCI) remains a devastating condition with poor prognosis and very limited treatment options. Affected patients are severely restricted in their daily activities.
C. Gollmann-Tepeköylü +20 more
semanticscholar +1 more source
A Chemically Defined TLR3 Agonist with Anticancer Activity
OncoImmunology, 2023 Toll-like receptor 3 (TLR3) agonists such as polyinosinic:polycytidylic acid (poly(I:C)) have immunostimulatory effects that can be taken advantage of to induce anticancer immune responses in preclinical models. In addition, poly(I:C) has been introduced into clinical trials to demonstrate its efficacy as an adjuvant and to enhance the immunogenicity ...
Le Naour, Julie +15 more
openaire +5 more sources