Results 111 to 120 of about 262,724 (386)

Increasing the Chemical Variety of Small-Molecule-Based TLR4 Modulators: An Overview

Frontiers in Immunology, 2020
Toll-Like Receptor 4 (TLR4) is one of the receptors of innate immunity. It is activated by Pathogen- and Damage-Associated Molecular Patterns (PAMPs and DAMPs) and triggers pro-inflammatory responses that belong to the repertoire of innate immune ...
Alessio Romerio, F. Peri
semanticscholar   +1 more source

Haptoglobin Acts as a TLR4 Ligand to Suppress Osteoclastogenesis via the TLR4–IFN-β Axis [PDF]

The Journal of Immunology, 2019
Abstract Haptoglobin (Hp), a type of acute-phase protein, is known to have a systemic anti-inflammatory function and to modulate inflammation by directly affecting immune cells, such as T cells, dendritic cells, and macrophages. However, the effects of Hp on osteoclast differentiation are not well studied, even though osteoclast ...
Jun-Oh Kwon, Won Jong Jin, Bongjun Kim, Hyunil Ha, Hong-Hee Kim, Zang Hee Lee   +5 more
openaire   +3 more sources

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

A Review: The Significance of Toll-Like Receptors 2 and 4, and NF-κB Signaling in Endothelial Cells during Atherosclerosis

Frontiers in Bioscience-Landmark
Atherosclerosis (AS) is a chronic inflammatory vascular disease that begins with endothelial activation followed by a series of inflammatory responses, plaque formation, and finally rupture.
Baoxin Yan, Xiaoxian Yu, Xianzhen Cai, Xiaojun Huang, Bin Xie, Danchun Lian, Jinhao Chen, Weiwen Li, Ying Lin, Junjun Ye, Jilin Li   +10 more
doaj   +1 more source

Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. [PDF]

, 2019
HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and containing viral factors.
Brichacek, Beda, Bukrinsky, Michael, Ditiatkovski, Michael, Dragoljevic, Dragana, Dubrovsky, Larisa, Fu, Ying, Hoang, Anh, Horvath, Anelia, Low, Hann, Meikle, Peter J, Miller, Yury I, Mukhamedova, Nigora, Murphy, Andrew, Ohkawa, Ryunosuke, Pushkarsky, Tatiana, Sviridov, Dmitri   +15 more
core   +3 more sources

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Associations of CYLD, JAK2 and TLR4 Genotypes with PSA Levels and Immunophenotype in Benign Prostatic Hyperplasia and Prostate Cancer

Frontiers in Bioscience-Landmark
Background: Prostate cancer (PCa) is one of the most common malignant tumors of the male urinary system, and its incidence and mortality rates have been increasing worldwide.
Le Vu Duy, Pham Thi Huong, Nguyen Trung Nam, Do Thi Trang, Nghiem Thi Minh Chau, Tran Thi Phuong Thao, Nguyen Huy Hoang, Nguyen Thien Tao, Can Van Mao, Nguyen Thi Xuan   +9 more
doaj   +1 more source

Transient receptor potential channel 1 deficiency impairs host defense and proinflammatory responses to bacterial infection by regulating protein kinase Cα signaling [PDF]

, 2015
Transient receptor potential channel 1 (TRPC1) is a nonselective cation channel that is required for Ca2+ homeostasis necessary for cellular functions. However, whether TRPC1 is involved in infectious disease remains unknown.
Birnbaumer, Lutz, Huang, Canhua, Li, Xuefeng, Privratsky, Breanna, Singh, Brij B., Sun, Yuyang, Tan, Shirui, Wang, Wenxue, Wei, Yu-Quan, Wu, Min, Ye, Yan, Zhou, Xikun, Zhou, Zongguang   +12 more
core   +1 more source

Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway

Frontiers in Cellular Neuroscience, 2019
Ischemic stroke is a devastating disease with long-term disability. However, the pathogenesis is unclear and treatments are limited. Meisoindigo, a second-generation derivative of indirubin, has general water solubility and is well-tolerated.
Yingze Ye, Tong Jin, Xu Zhang, Zhi Zeng, Baixin Ye, Jinchen Wang, Yi Zhong, X. Xiong, Lijuan Gu   +8 more
semanticscholar   +1 more source

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Advanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen, Nghi M. Tran, Kyle H. Vining   +2 more
wiley   +1 more source