Results 241 to 250 of about 274,305 (384)

<i>TLR4</i> rs11536889 and rs1927914 SNPs are Associated with Ischemic Stroke Risk in a Southern Chinese Han Population. [PDF]

Int J Gen Med
Liu Y, Zhou K, Yi H.
europepmc   +1 more source

Advances in Pharmacological Insights of Borago officinalis: A Comprehensive Review

Biological Diversity, EarlyView.
ABSTRACT Recent growth in phytotherapy and product‐based drug development has increased interest in this plant because of its broad pharmacological activity. This review aims to examine the pharmacological activities, mechanisms, and potential applications of Borago officinalis, focusing on its primary bioactive constituents and therapeutic ...
Zahra Sufwan, Javed Akhtar Ansari, Farogh Ahsan   +2 more
wiley   +1 more source

The immune receptors TLR4 and SLAMF1 regulate TNF release by human metapneumovirus in human macrophages. [PDF]

Front Immunol
Sæterhaug Bye K, Rian K, Ryan L, Espevik T, Anthonsen MW, Yurchenko M.   +5 more
europepmc   +1 more source

Oxidative Stress Modulation and Antileishmanial Activity of Salvinia auriculata

Chemistry &Biodiversity, EarlyView.
Ethanolic extract of Salvinia auriculata showed significant antioxidant and antileishmanial activities. Salviniside II, the major metabolite, was isolated, structurally characterized, and evaluated, but exhibited weaker antiparasitic effects when compared to the whole extract.
Augusto César Rodrigues, Emilha Uzum Papaya, Fernanda da Silva, Carla Cardozo Pinto de Arruda, Edson Lucas dos Santos, Kely de Picoli Souza, Carlos Alexandre Carollo   +6 more
wiley   +1 more source

A Requirement for Microglial TLR4 in Leukocyte Recruitment into Brain in Response to Lipopolysaccharide [PDF]

, 2006
Hong Zhou, Benoît M. Lapointe, Stephen Clark, Lori Zbytnuik, Paul Kubes   +4 more
openalex   +1 more source

Advanced Glycation End Products Promote PGE₂ Production in Ca9-22 Cells via RAGE/TLR4-Mediated PKC-NF-κB Pathway. [PDF]

Cells
Ono M, Tanabe N, Ichikawa R, Tomita K, Manaka S, Seki H, Imai Y, Aoki M, Masai Y, Takayama T, Suzuki N, Sato S.   +11 more
europepmc   +1 more source

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, EarlyView.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

Computational development of multi-epitope vaccine to induce adaptive immunity against multi-drug resistant Prevotella intermedia. [PDF]

BMC Infect Dis
Kanwal A, Shah M, Khan MU, Latif M, Anum H, Younas S, Aljasham AT, Ojha SC.   +7 more
europepmc   +1 more source

Rho Kinase Type 1 (ROCK1) Promotes Lipopolysaccharide-induced Inflammation in Corneal Epithelial Cells by Activating Toll-Like Receptor 4 (TLR4)-Mediated Signaling

, 2018
Jianying Gong, Linan Guan, Pei Tian, Chao Li, Yi Zhang   +4 more
openalex   +2 more sources

Development and Characterization of a Noncovalent Stimulator of Interferon Genes Proteolysis‐Targeting Chimeras

ChemMedChem, EarlyView.
The design, synthesis, and initial biological evaluation of noncovalent stimulator of interferon genes degraders are presented. The lead from this series, BH690L, exhibits an effective concentration for half‐maximal degradation (DC50) of 11.3 nM and a maximum level of degradation (Dmax) of 0.67.
Bo Hu, Adam S. Duerfeldt
wiley   +1 more source