Results 241 to 250 of about 222,436 (284)

In Silico Design and Evaluation of TcGAPDH as a Vaccine Against Chagas Disease: A Reverse Vaccinology Approach. [PDF]

Acta Parasitol
Nava-Cuamatzi V, Buendia-Corona RE, González-Vázquez MC, Cedillo-Ramirez ML, Carabarin-Lima A.   +4 more
europepmc   +1 more source

Single Cell Analysis Reveals Dynamic Changes of Distinct Cell Populations in Human Nickel Allergy

Allergy, EarlyView.
We investigated cell types mediating the early and late inflammatory responses in human Ni2+‐allergy by scRNA‐Seq. Early responsiveness was mainly mediated by TLR4+TAGLN− endothelial cells indirectly activating TLR4−KRT16+ keratinocytes, and CCR7+DCN+ DCs. Late responsiveness was crucially driven by infiltration of KLF2+ central memory T cells and TLR4+
Marc Schmidt, Andrea Knorz, Katharina Meder, Simon Goller, Fabian Imdahl, Yamila Rocca, Matthias Goebeler, Pierre Khoueiry   +7 more
wiley   +1 more source

Decreased adipokine CTRP4 in CAD patients: CTRP4 attenuates atherosclerosis via inhibition of RAGE and TLR4. [PDF]

Clin Transl Med
Shu X, Li F, Chen J, Wu X, Tao L, Amuti A, Chen S, Quan J, Liu J, Maimati Y, Ding F, Shen Y, Chen Q, Shen W, Zhang R, Dai Y, Wang X, Lu L.   +17 more
europepmc   +1 more source

The Therapeutic Potential of Farm Dust Extracts in a Mouse Model of Eosinophilic Inflammation

Allergy, EarlyView.
Farm dust extract (FDE) treatment reduces airway eosinophilia, mucus overproduction, and MHC‐II expression on DCs, limiting antigen presentation and Th2 inflammation. It increases PD‐L1 on DCs, promoting T cell deactivation. Additionally, FDE enhances Tregs and upregulates CTLA‐4, reinforcing suppression.
Rabia Ülkü Korkmaz, Jimmy Omony, Xiaomei Tan, Markus Klotz, Guilherme Dragunas, Sirui Chen, Soni Shankhwar, Zeynep Ertüz, Christoph Müller, Mohab Ragab, Aicha Jeridi, Romina Augustin, Janna Nawroth, Theodore S. Kapellos, Bettina Rankl, Ali Önder Yildirim, Erika von Mutius   +16 more
wiley   +1 more source

Advanced Glycation End-Products Contribute to Delayed Diabetic Corneal Epithelial Wound Healing via the TLR4 Signaling. [PDF]

Invest Ophthalmol Vis Sci
Yu Y, Zhang Y, Tang Y, Ma L, Wei C, Bai X.   +5 more
europepmc   +1 more source

<i>Panax notoginseng</i> Saponins Ameliorate High-Fat Diet-Induced Liver Injury via Mechanisms Involving TLR4-Mediated Signaling and Lipid Metabolism. [PDF]

Food Sci Nutr
Li R, Ma J, Li M, Zeng B, Li X, Bi X, Zhao X, Gao Q, Yao Y, Jiang Y, Zhang C, Ya F.   +11 more
europepmc   +1 more source

Functional toll-like receptor 4 links endotoxin sensing to platelet priming in feline platelets. [PDF]

Front Vet Sci
Li RHL, Shaverdian M, Chen C, Stuhlmann C, Stern JA, Nguyen N.   +5 more
europepmc   +1 more source

Natural triterpenoid Ardisiacrispin B attenuates colitis-associated cancer via JAK2/STAT3 pathway and gut microbiota modulation. [PDF]

Nat Prod Bioprospect
Ullah H, Cui H, Li Y, Ye B, Peng W, Ruan Y, Dai W, Ma C, Hu X.   +8 more
europepmc   +1 more source

Immunoinformatic-driven design of a multi-epitope vaccine against <i>Helicobacter</i> <i>pylori</i>. [PDF]

Biochem Biophys Rep
Rahimi-Farsi N, Bostanian F, Ahmadi K, Zangooie A, Sedighi M, Shahbazi B, Mottaghi-Dastjerdi N.   +6 more
europepmc   +1 more source