Results 281 to 290 of about 262,724 (386)

Astragalus Polysaccharide Alleviates COPD‐Associated Skeletal Muscle Dysfunction Through Suppression of Inflammation and Cellular Senescence

Food Frontiers, EarlyView.
APS alleviates COPD‐associated skeletal muscle dysfunction in both animal and cellular models. This study provides compelling preclinical evidence supporting APS as a promising functional food ingredient for mitigating skeletal muscle wasting in COPD. ABSTRACT Astragalus polysaccharide (APS) exhibits various pharmacological properties.
Yan Mou, Yunhuan Liu, Yanjuan Chen, Ruling Shen, Aoxue Yan, Tongtong Liao, Yanyin Liu, Hejun Su, Zhenming He, Yue Wang, Lin Qi, Huili Zhu, Haiyan Ge   +12 more
wiley   +1 more source

Clinical Significance and Prognostic Value of TLR4 and AGER in Inflammatory Breast Cancer. [PDF]

Cancers (Basel)
Paiva LDAS, Teles ACF, Souza JDS, Oliveira PRA, Alves BES, Coelho MTB, Cajado AG, Maia IFVC, Silva PGB, Cavalcante DIM, Cunha MDPSS, Arruda LM, Lima-Júnior RCP, Rogatto SR, Wong DVT.   +14 more
europepmc   +1 more source

IL-10 Released by Concomitant TLR2 Stimulation Blocks the Induction of a Subset of Th1 Cytokines That Are Specifically Induced by TLR4 or TLR3 in Human Dendritic Cells [PDF]

, 2004
Fabio Re, Jack L. Strominger
openalex   +1 more source

Bioactive polysaccharides and their potential health benefits in reducing the risks of metabolic syndrome: A review

Food Biomacromolecules, EarlyView.
Abstract Metabolic syndrome (MetS) is a complex noncommunicable condition characterized by central obesity, insulin resistance, hyperlipidemia, hypertension, and hyperglycemia. Epidemiological evidence shows that MetS affects a third of the global population; however, due to its complex pathogenesis and limited drug therapy options, the increasing ...
Josiah Owuor Oyalo, Evelyne Nkirote Gikundi, Mercy Adhiambo Ndiege, Kevin Omondi Aduol   +3 more
wiley   +1 more source

The Resistin/TLR4/miR-155-5p axis: a novel signaling pathway in the onset of hypothalamic neuroinflammation. [PDF]

J Neuroinflammation
Prévost M, Crépin D, Rifai SA, Poizat G, Gonçalves M, van Barneveld F, Shadpay R, Taouis K, Riffault L, Benomar Y, Taouis M.   +10 more
europepmc   +1 more source

Frontline: Control of Anaplasma phagocytophilum, an obligate intracellular pathogen, in the absence of inducible nitric oxide synthase, phagocyte NADPH oxidase, tumor necrosis factor, Toll‐like receptor (TLR)2 and TLR4, or the TLR adaptor molecule MyD88 [PDF]

, 2004
Friederike D. von Loewenich, Diana G. Scorpio, Udo Reischl, J. Stephen Dumler, Christian Bogdan   +4 more
openalex   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Toll-Like Receptors in the Immunotherapy Era: Dual-Edged Swords of Tumor Immunity and Clinical Translation. [PDF]

MedComm (2020)
Maihemuti N, Shi Y, Zhang K, Jiang X, Chu J, Xu Y, Xu Z, Wang K.   +7 more
europepmc   +1 more source

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Ibrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti, Valeria De Matteis   +5 more
wiley   +1 more source

Gut microbiota dysbiosis exacerbates heart failure by the LPS-TLR4/NF-κB signalling axis: mechanistic insights and therapeutic potential of TLR4 inhibition. [PDF]

J Transl Med
Zhang C, Teng X, Cao Q, Deng Y, Yang M, Wang L, Rui D, Ling X, Wei C, Chen Y, Lu D, Zhang H.   +11 more
europepmc   +1 more source