Results 71 to 80 of about 262,724 (386)

TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation

EMBO Reports
Abstract Toll-like receptor 4 (TLR4) signaling at the plasma membrane and in endosomes results in distinct contributions to inflammation and host defence. Current understanding indicates that endocytosis of cell surface-activated TLR4 is required to enable subsequent signaling from endosomes.
Thomas E Schultz, Carmen D Mathmann, Leslie C Domínguez Cadena, Timothy W Muusse, Hyoyoung Kim, James W Wells, Glen C Ulett, Jessica A Hamerman, Andrew J Brooks, Bostjan Kobe, Matthew J Sweet, Katryn J Stacey, Antje Blumenthal   +12 more
openaire   +2 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Ivermectin decreases inflammation and imiquimod–induced psoriasis-like skin lesions in rat via targeting TLR4 / p65 NF-κB [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Psoriasis is a chronic skin disease that usually manifests as white and silver spots on the skin. Because of its anti-inflammatory properties, we investigated the effects of ivermectin (IVM) on imiquimod (IMQ)-induced psoriasis in rats ...
Tayebeh Noori, Antoni Sureda, Samira Shirooie   +2 more
doaj   +1 more source

MicroRNA-182-5p relieves murine allergic rhinitis via TLR4/NF-κB pathway

Open Medicine, 2020
Allergic rhinitis (AR) is one of the most common chronic diseases. This study examined whether microRNA (miR)-182-5p plays a role in AR by regulating toll-like receptor 4 (TLR4). First, data demonstrated that TLR4 was a target of miR-182-5p. Subsequently,
Zhang Aichun, Jin Yangzi
doaj   +1 more source

Role of TLR4 in the gut-brain axis in Parkinson’s disease: a translational study from men to mice

Gut, 2018
Objective Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases.
P. Perez‐Pardo, H. Dodiya, P. Engen, C. Forsyth, Andrea M Huschens, M. Shaikh, R. Voigt, A. Naqib, S. Green, J. Kordower, K. Shannon, J. Garssen, A. Kraneveld, A. Keshavarzian   +13 more
semanticscholar   +1 more source

TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance To ensure immunity, and yet limit pathology, inflammatory responses must be confined within the proverbial “Goldilocks zone.” TLR4 is the prototypical sensor that orchestrates inflammatory responses through a series of well-characterized ...
Lee Swanson, G. Katkar, J. Tam, Rama F. Pranadinata, Y. Chareddy, Jane Coates, Mahitha Shree Anandachar, Vanessa Castillo, Joshua Olson, V. Nizet, I. Kufareva, Soumita Das, P. Ghosh   +12 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

NEAT1 promotes LPS-induced inflammatory injury in macrophages by regulating miR-17-5p/TLR4

Open Medicine, 2020
The inflammatory response of macrophages is responsible for sepsis. Long noncoding RNA nuclear enriched abundant transcript 1 (NEAT1) has been reported to be involved in sepsis development. However, its underlying mechanism remains largely unclear.
Li Yanhui, Guo Wei, Cai Yeping
doaj   +1 more source

Mast cell subsets and their functional modulation by the Acanthocheilonema viteae product ES-62 [PDF]

, 2013
ES-62, an immunomodulator secreted by filarial nematodes, exhibits therapeutic potential in mouse models of allergic inflammation, at least in part by inducing the desensitisation of Fc휀RI-mediated mast cell responses.
Al-Riyami, Lamyaa, Ball, Dimity, Bell, Kara, Coates, Michelle, Harnett, Margaret, Harnett, William, Rzepecka, Justyna, Tay, Hwee Kee   +7 more
core   +2 more sources

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death

Communications Biology, 2020
The molecular events causing memory loss and neuronal cell death in Alzheimer’s disease (AD) over time are still unknown. Here we found that picomolar concentrations of soluble oligomers of synthetic beta amyloid (Aβ42) aggregates incubated with BV2 ...
Craig D. Hughes, Minee L. Choi, J. Yi, Seung-Chan Kim, A. Drews, P. George-Hyslop, C. Bryant, S. Gandhi, Kwangwook Cho, D. Klenerman   +9 more
semanticscholar   +1 more source