Results 71 to 80 of about 274,305 (384)

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Anti-inflammatory potential of black cumin seed oil and its nanoemulsion formulation against lipopolysaccharide-induced liver injury in mice

Asian Pacific Journal of Tropical Biomedicine
Objective: To evaluate the anti-inflammatory effect of black cumin seed oil (BCSO) and its nanoemulsion on lipopolysaccharide (LPS)-induced liver injury in mice. Methods: LPS-induced acute liver injury mouse model was used to evaluate the effects of BCSO
Hesham Haffez, Rehab Hosni, Shady A. Swidan, Hatem K. Amin   +3 more
doaj   +1 more source

TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance To ensure immunity, and yet limit pathology, inflammatory responses must be confined within the proverbial “Goldilocks zone.” TLR4 is the prototypical sensor that orchestrates inflammatory responses through a series of well-characterized ...
Lee Swanson, Gajanan D. Katkar, J. Tam, Rama F. Pranadinata, Y. Chareddy, Jane Coates, Mahitha Shree Anandachar, Vanessa Castillo, Joshua Olson, V. Nizet, I. Kufareva, Soumita Das, P. Ghosh   +12 more
semanticscholar   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Role of TLR4 Receptor Complex in the Regulation of the Innate Immune Response by Fibronectin

Cells, 2020
Chronic inflammation and subsequent tissue fibrosis are associated with a biochemical and mechanical remodeling of the fibronectin matrix. Due to its conformational lability, fibronectin is considerably stretched by the contractile forces of the fibrotic
Mingzhe Zheng, Anthony Ambesi, Paula J. McKeown-Longo   +2 more
doaj   +1 more source

Molecular signatures of a TLR4 agonist-adjuvanted HIV-1 vaccine candidate in humans [PDF]

, 2018
Systems biology approaches have recently provided new insights into the mechanisms of action of human vaccines and adjuvants. Here, we investigated early transcriptional signatures induced in whole blood of healthy subjects following vaccination with a ...
Anderson, J, Harandi, AM, Kratochvil, S, McKay, PF, Olafsdottir, TA, Persson, J, Shattock, RJ, östensson, M   +7 more
core   +2 more sources

The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization

Advanced Biology, EarlyView.
This study explores the use of collagen‐hyaluronic acid (HA) hydrogels for the 3D culture of macrophages, providing a useful tool for modelling macrophage behavior in tissues and diseases. It highlights how hydrogel composition, mechanical properties, and preparation methods influence macrophage behavior, revealing for the first time that HA's ...
Tiah CL Oates, Jasmin Boyd, Louise Dolan, C de Kergariou, Jingwen Zhu, Ash Toye, Adam W Perriman, Asme Boussahel   +7 more
wiley   +1 more source

Gene dynamics of toll-like receptor 4 through a population bottleneck in an insular population of water voles (Arvicola amphibius) [PDF]

, 2015
Acknowledgments We would like to thank all colleagues who have contributed to fieldwork and sampling during this study. We would especially like to thank Marius Wenzel and Sandra Telfer for collaboration with different aspects of the study, and Dave ...
Douglas, Alex, Gavan, Martha K., Oliver, Matthew K., Piertney, Stuart B.   +3 more
core   +2 more sources

Role of TLR4 in the gut-brain axis in Parkinson’s disease: a translational study from men to mice

Gut, 2018
Objective Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases.
P. Perez‐Pardo, H. Dodiya, P. Engen, C. Forsyth, Andrea M Huschens, M. Shaikh, R. Voigt, A. Naqib, S. Green, J. Kordower, K. Shannon, J. Garssen, A. Kraneveld, A. Keshavarzian   +13 more
semanticscholar   +1 more source

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death

Communications Biology, 2020
The molecular events causing memory loss and neuronal cell death in Alzheimer’s disease (AD) over time are still unknown. Here we found that picomolar concentrations of soluble oligomers of synthetic beta amyloid (Aβ42) aggregates incubated with BV2 ...
Craig D. Hughes, Minee L. Choi, J. Yi, Seung-Chan Kim, A. Drews, P. George-Hyslop, C. Bryant, S. Gandhi, Kwangwook Cho, D. Klenerman   +9 more
semanticscholar   +1 more source