Results 71 to 80 of about 175,490 (344)

Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective

Diabetes, Metabolic Syndrome and Obesity, 2020
Zhaoping Wang,1 Xiaolin Ni,1,2 Li Zhang,1 Liang Sun,1 Xiaoquan Zhu,1 Qi Zhou,1 Ze Yang,1 Huiping Yuan1 1The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, People’s Republic of China; 2Graduate School of
Wang Z, Ni X, Zhang L, Sun L, Zhu X, Zhou Q, Yang Z, Yuan H   +7 more
doaj  

Effects of the interaction of Notch and TLR4 pathways on inflammation and heart function in septic heart

Open Life Sciences, 2022
We investigated the role of the interaction between the Notch and Toll-like receptor 4 (TLR4) pathways in septic myocardial injury. The sepsis model was induced in rats with lipopolysaccharide (LPS). Rats were divided into control, LPS, LPS + TAK242 ((6R)
Liu Ziyang, Li Wenli, Cao Yang, Zhang Xiaoxia, Yang Kai, Yin Fukang, Yang Meng, Peng Peng   +7 more
doaj   +1 more source

Interplay between RAGE and TLR4 Regulates HMGB1-Induced Inflammation by Promoting Cell Surface Expression of RAGE and TLR4

Journal of Immunology, 2020
Key Points The cell surface receptors RAGE and TLR4 regulate HMGB1-induced inflammation. RAGE promotes TLR4 trafficking to the cell surface but does not affect its translation.
Hanhui Zhong, Xiaoliang Li, Shuangnan Zhou, P. Jiang, Xiaolei Liu, Mingwen Ouyang, Y. Nie, Xinying Chen, Liangqing Zhang, Youtan Liu, Taoliangshan Tao, Jing Tang   +11 more
semanticscholar   +1 more source

Maintenance of homeostasis by TLR4 ligands

Frontiers in Immunology
Immunotherapy is renowned for its capacity to elicit anti-infective and anti-cancer effects by harnessing immune responses to microbial components and bolstering innate healing mechanisms through a cascade of immunological reactions. Specifically, mammalian Toll-like receptors (TLRs) have been identified as key receptors responsible for detecting ...
Masataka Oda, Hirofumi Yamamoto, Takashige Kawakami   +2 more
openaire   +3 more sources

Abrupt Expression of TLR4 in TLR4-Deficient Macrophages Imposes a Selective Disadvantage: Genetic Evidence for TLR4-Dependent Responses to Endogenous, Nonmicrobial Stimuli [PDF]

The Journal of Immunology, 2006
Abstract TLR4 is crucial for macrophage responses to LPS. It is less clear whether TLR4 may also transduce signals from host factors, and if so, with what consequences. Immortalized bone marrow-derived macrophage cell lines, termed T4Cr and T4ko, were established from TLR4null strains, C57BL/10ScNCr and TLR4 knockout mice, respectively ...
Zhaoying Xiang, Hongwei Yu, Danuta Radzioch, Aihao Ding, Carl Nathan, Ellen F. Cohn   +5 more
openaire   +2 more sources

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

Porphyromonas gingivalis lipopolysaccharide induces cognitive dysfunction, mediated by neuronal inflammation via activation of the TLR4 signaling pathway in C57BL/6 mice

Journal of Neuroinflammation, 2018
Porphyromonas gingivalis lipopolysaccharide (P. gingivalis-LPS) is one of the major pathogenic factors of chronic periodontitis (CP). Few reports on the correlation between P. gingivalis-LPS and cognitive function exist.
Jing Zhang, Chunbo Yu, Xuan Zhang, Huiwen Chen, Jiachen Dong, Weili Lu, Zhongchen Song, Wei Zhou   +7 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Toll-like receptor 4 signaling-mediated responses are critically engaged in optimal host protection against highly virulent Mycobacterium tuberculosis K infection

Virulence, 2020
Toll-like receptors (TLRs) play critical roles in the innate recognition of Mycobacterium tuberculosis (Mtb) by host immune cells. However, controversy has arisen regarding the role of TLR4 in determining the outcomes of Mtb infection.
Jaehun Park, Hongmin Kim, Kee Woong Kwon, Hong-Hee Choi, Soon Myung Kang, Jung Joo Hong, Sung Jae Shin   +6 more
doaj   +1 more source

Neutrophil Extracellular Traps Promote Inflammatory Responses in Psoriasis via Activating Epidermal TLR4/IL-36R Crosstalk

Frontiers in Immunology, 2019
Epidermal infiltration of neutrophils is a hallmark of psoriasis, where their activation leads to release of neutrophil extracellular traps (NETs). The contribution of NETs to psoriasis pathogenesis has been unclear, but here we demonstrate that NETs ...
S. Shao, H. Fang, E. Dang, K. Xue, Jieyu Zhang, Bing Li, Hongjiang Qiao, T. Cao, Y. Zhuang, S. Shen, Tongmei Zhang, P. Qiao, Caixia Li, J. Gudjonsson, Gang Wang   +14 more
semanticscholar   +1 more source