Results 71 to 80 of about 222,436 (284)

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, EarlyView.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

Characterization of structural and immunological properties of a fusion protein between flagellin from Salmonella and lumazine synthase from Brucella [PDF]

, 2017
Aiming to combine the flexibility of Brucella lumazine synthase (BLS) to adapt different protein domains in a decameric structure and the capacity of BLS and flagellin to enhance the immunogenicity of peptides that are linked to their structure, we ...
Berguer, Paula Mercedes, Biedma, Marina Elizabeth, Blancá, Bruno Martin, Cayet, D., Errea, Agustina Juliana, Goldbaum, Fernando Alberto, Hiriart, Yanina, Moreno, Griselda Noemí, Rinaldi, Jimena Julieta, Rossi, Andrés Hugo, Rumbo, Martín, Sirard, J.C.   +11 more
core   +3 more sources

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Associations of CYLD, JAK2 and TLR4 Genotypes with PSA Levels and Immunophenotype in Benign Prostatic Hyperplasia and Prostate Cancer

Frontiers in Bioscience-Landmark
Background: Prostate cancer (PCa) is one of the most common malignant tumors of the male urinary system, and its incidence and mortality rates have been increasing worldwide.
Le Vu Duy, Pham Thi Huong, Nguyen Trung Nam, Do Thi Trang, Nghiem Thi Minh Chau, Tran Thi Phuong Thao, Nguyen Huy Hoang, Nguyen Thien Tao, Can Van Mao, Nguyen Thi Xuan   +9 more
doaj   +1 more source

HMGB1/TLR4 Signaling Affects Regulatory T Cells in Acute Lung Injury

Journal of Inflammation Research, 2021
Min Zhou,1,* Yadi Zhang,2,* Rui Tang,1 Haiyan Liu,1 Min Du,1 Zhi Gao,1 Zongshu Ji,1 Haoshu Fang3 1Neurocritical Care Unit, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei,
Zhou M, Zhang Y, Tang R, Liu H, Du M, Gao Z, Ji Z, Fang H   +7 more
doaj  

Septic Pulmonary Embolism in a Patient with Generalized Salmonellosis: a Clinical Case and Meta-Analysis

Антибиотики и Химиотерапия, 2020
Nontyphoid Salmonella are gram-negative bacteria that induce Th1-mediated immunity. They rarely lead to a generalized infection, primarily developing in immunocompromised patients with cellular immunity defects.
A. D. Strutynskaya, M. A. Karnaushkina, I. E. Tyurin, M. P. Suvorova, S. V. Yakovlev   +4 more
doaj   +1 more source

Increased NFκ-B Activity in HCT116 Colorectal Cancer Cell Line Harboring TLR4 Asp299Gly Variant [PDF]

, 2012
Toll-Like Receptor 4 (TLR4), considered one of the most important TLR, recognizes lipopolysaccharide of gram-negative bacteria. Recognition of ligands by TLRs induces signaling pathways resulting in activation of transcriptional factors such as NF-κB ...
Davoodi, H., Hashemi, S.R., Seow, H.F.
core  

Nucleosomes and neutrophil extracellular traps in septic and burn patients [PDF]

, 2017
NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1
Carestia, Agostina, D'Atri, Lina Paola, Fandiño, María Eugenia, Fondevila, Carlos, Guzman, María Alejandra, Kaufman, Tomás, Magosevich, Débora, Moreno, María Carolina, Schattner, Mirta Ana   +8 more
core   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Toll-like receptor (TLR) 2 and TLR4 gene expression in canine heart [PDF]

, 2007
Toll-like receptors (TLRs) are archetypal pattern recognition receptors of immediate importance for an efficacious innate immune response. TLRs exhibit marked differential tissue activity and their levels within a discrete cell type can be highly dynamic.
Blecha, Frank, Linde, Annika, Melgarejo, Tonatiuh   +2 more
core   +2 more sources