Results 81 to 90 of about 274,305 (384)

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

مقایسه بیان ژن های لاکتوفرین و TLR4 در سلول های سوماتیک شیر گاو هلشتاین، بومی گیلان و آمیخته‌های حاصل از آنها [PDF]

تحقیقات تولیدات دامی, 2016
هدف تحقیق حاضر مقایسه بیان ژن­های لاکتوفرین و TLR4 در سلول­های سوماتیک شیر گاو و بررسی تفاوت­های ژنتیکی و آمیخته­گری بر بیان ژن­های سیستم ایمنی و همچنین اثرات ورم پستان بر بیان ژن­های مذکور است.
پری ناز رضوانی, سید حسین حسینی مقدم, میثاق مریدی, محمد روستایی علی مهر   +3 more
doaj  

A mucin-like peptide from Fasciola hepatica instructs dendritic cells with parasite specific Th1-polarizing activity [PDF]

, 2017
Fasciolosis is a trematode zoonosis of interest in public health and cattle production. We report here the immunostimulatory effect of a 66 mer mucin-like peptide from Fasciola hepatica (Fhmuc), which synergizes with lipopolysaccharide (LPS) to promote ...
Brossard, Natalie, Carmona, Carlos, Dergan Dylon, Leonardo Sebastian, Freire, Teresa, Noya, Verónica, Rabinovich, Gabriel Adrián, Rodríguez, Ernesto   +6 more
core   +1 more source

Epithelial TLR4 signaling activates DUOX2 to induce microbiota-driven tumorigenesis.

Gastroenterology, 2020
BACKGROUND & AIMS Chronic colonic inflammation leads to dysplasia and cancer in patients with inflammatory bowel disease (IBD). We have described the critical role of innate immune signaling via toll-like receptor 4 (TLR4) in the pathogenesis of ...
Juan F Burgueño, J. Fritsch, Eddy E. González, K. Landau, Ana M. Santander, I. Fernández, Hajar Hazime, Julie M. Davies, R. Santaolalla, Matthew C L Phillips, Sophia Diaz, Rishu Dheer, Nivis Brito, J. Pignac-Kobinger, E. Fernández, G. Conner, M. Abreu   +16 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective

Diabetes, Metabolic Syndrome and Obesity, 2020
Zhaoping Wang,1 Xiaolin Ni,1,2 Li Zhang,1 Liang Sun,1 Xiaoquan Zhu,1 Qi Zhou,1 Ze Yang,1 Huiping Yuan1 1The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, People’s Republic of China; 2Graduate School of
Wang Z, Ni X, Zhang L, Sun L, Zhu X, Zhou Q, Yang Z, Yuan H   +7 more
doaj  

RISK FOR PNEUMONIA AND TLR2 AND TLR4 GENE POLYMORPHISMS: A META-ANALYSIS

Общая реаниматология, 2016
Pneumonia is one of the most common infections with high mortality rates. The gene polymorphism of Toll-like receptors that belong to the first line of defense of the immune system can make a considerable contribution to individual variability due to the
S. V. Smirnova, L. E. Salnikova
doaj   +1 more source

Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages [PDF]

, 2018
open11noSeveral studies suggest that curcumin and related compounds possess antioxidant and anti-inflammatory properties including modulation of lipopolysaccharide- (LPS-) mediated signalling in macrophage cell models. We here investigated the effects of

core   +1 more source

Interplay between RAGE and TLR4 Regulates HMGB1-Induced Inflammation by Promoting Cell Surface Expression of RAGE and TLR4

Journal of Immunology, 2020
Key Points The cell surface receptors RAGE and TLR4 regulate HMGB1-induced inflammation. RAGE promotes TLR4 trafficking to the cell surface but does not affect its translation.
Hanhui Zhong, Xiaoliang Li, Shuangnan Zhou, P. Jiang, Xiaolei Liu, Mingwen Ouyang, Y. Nie, Xinying Chen, Liangqing Zhang, Youtan Liu, Taoliangshan Tao, Jing Tang   +11 more
semanticscholar   +1 more source

A Novel Core–Shell Hydrogel 3D Model for Studying Macrophage Mechanosensing and Foreign Body Giant Cell Formation

Advanced Healthcare Materials, EarlyView.
The foreign body response (FBR) to biomaterials is primarily driven by macrophages, which often fuse into destructive foreign body giant cells (FBGCs). To address the limited understanding of FBGC formation, a novel microscale core–shell hydrogel 3D model is developed using heterogeneous alginate‐collagen microcapsules with varying stiffness, offering ...
Manisha Mahanty, Wenquan Ou, Xiaoping Zhu, Jonathan S Bromberg, Xiaoming He, Shaik O. Rahaman   +5 more
wiley   +1 more source