Results 101 to 110 of about 16,414 (200)

Intestinal Serotonin Transporter Inhibition by Toll-Like Receptor 2 Activation. A Feedback Modulation [PDF]

, 2016
This is the final version of the article. Available from Public Library of Science via the DOI in this record.TLR2 is a microbiota recognition receptor that has been described to contribute to intestinal homeostasis and to ameliorate inflammatory ...
Latorre, E, Layunta, E, Grasa, L, Castro, M, Pardo, J, Gomollón, F, Alcalde, AI, Mesonero, JE   +7 more
core   +3 more sources

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

TLRs, future potential therapeutic targets for RA [PDF]

, 2017
Toll like receptor (TLR)s have a central role in regulating innate immunity and in the last decade studies have begun to reveal their significance in potentiating autoimmune diseases such as rheumatoid arthritis (RA).
Elshabrawy, Hatem A., Essani, Abdul E., Fox, David A., Shahrara, Shiva, Szekanecz, Zoltán   +4 more
core   +1 more source

Endometrial Microbiome and Implantation: From Basic Knowledge to Clinical Medicine

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Background Recurrent implantation failure (RIF) is an infertility condition in which uterine factors remain difficult to diagnose and treat. Recent studies implicate the endometrial microbiome in implantation. Methods This clinically oriented narrative review summarizes female reproductive tract microbiota and evidence on endometrial ...
Daiki Hiratsuka, Mitsunori Matsuo, Yasushi Hirota   +2 more
wiley   +1 more source

Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6

Gastric Cancer
AbstractHelicobacter pylori (H. pylori, Hp) has been designated a class I carcinogen and is closely associated with severe gastric diseases. During colonization in the gastric mucosa, H. pylori develops immune escape by inducing host immune tolerance. The gastric epithelium acts as the first line of defense against H.
Xiulin Zhang, Yulong He, Xiaolu Zhang, Bo Fu, Zidai Song, Wei Wang, Rui Fu, Xuancheng Lu, Xing Jin, Jing Lv, Meng Guo, Xueyun Huo, Xin Liu, Jiarui Lu, Xiaoyan Du, Zhongming Ge, Zhenwen Chen, Changlong Li   +17 more
openaire   +3 more sources

Dysregulation of Toll-Like Receptor Signaling-Associated Gene Expression in X-Linked Agammaglobulinemia: Implications for Correlations Genotype-Phenotype and Disease Expression

Journal of Innate Immunity
Introduction: In X-linked agammaglobulinemia (XLA), the diversity of BTK variants complicates the study of genotype-phenotype correlations. Since BTK negatively regulates toll-like receptors (TLRs), we investigated if distinct BTK mutation types ...
Marcelo Teocchi, Thaís de Andrade Eugênio, Lia Furlaneto Marega, Isabella Quinti, Maria Marluce dos Santos Vilela   +4 more
doaj   +1 more source

Association of TLR6 gene polymorphisms with zootechnical parameters in Holstein cattle in northern Antioquia

Revista Facultad Nacional de Agronomía Medellín, 2017
Specialized dairy systems are one of the most important lines in the agricultural sector in Colombia and the world. Currently there are strategies, both of environmental management and animal breeding, seeking to optimize the production.
Juan Pablo Arismendy Morales, Albeiro López Herrera, Julián Echeverri Zuluaga   +2 more
doaj   +1 more source

Iron‐related intercellular communication in the liver: Main players and mechanisms

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Iron exchange between liver cell types is vital for organism health, yet its mechanisms remain poorly understood. In this review, we address intercellular communication governing hepatic iron regulation across different liver diseases. We summarize recent insights into how hepatocytes, macrophages, endothelial and stellate cells coordinate iron storage,
Óscar Fonseca, Paulo J. Oliveira, Martina U. Muckenthaler, Ana C. Moreira, M. Salomé Gomes   +4 more
wiley   +1 more source

DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
Aim. Evaluate the fraction of various TLR1-TLR6 haplotypes in populations of Russians, Bashkir and Nagaybak of Chelyabinsk Region. Materials and methods.
A. L Burmistrova, A. V Evdokimov, D. S Stashkevich, Yu. Yu Filippova, T. A Suslova   +4 more
doaj  

Species-Specific Recognition of Aspergillus fumigatus by Toll-like Receptor 1 and Toll-like Receptor 6 [PDF]

, 2017
Background. Aspergillus fumigatus causes invasive aspergillosis, a potentially fatal infection in oncohematological patients. Innate immune detection of A. fumigatus involves Toll-like receptor (TLR) 4 and TLR2, which forms a heterodimer with either TLR1
Bochud, Pierre-Yves, Boeckh, Michael, Calandra, Thierry, Coste, Alix, Jaton, Katia, Latgé, Jean-Paul, Le Roy, Didier, Monod, Michel, Roger, Thierry, Rubino, Ivana   +9 more
core