Results 1 to 10 of about 74,934 (299)

Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice

Nature Communications
Toll-like receptor 9 (TLR9) recognizes self-DNA and plays intricate roles in systemic lupus erythematosus (SLE). However, the molecular mechanism regulating the endosomal TLR9 response is incompletely understood.
Hai Ni, Bo Liu, Cliff Y Yang
exaly   +3 more sources

Mitochondrial DNA induces nucleus pulposus cell pyroptosis via the TLR9-NF-κB-NLRP3 axis

Journal of Translational Medicine, 2023
Background Nucleus pulposus cell (NPC) death and progressive reduction play important roles in intervertebral disc degeneration (IVDD). As part of a damage-associated molecular pattern, mitochondrial DNA (mtDNA) can be recognized by TLR9 and triggers the
Peng Lu, Huayong Zheng, Hao Meng, Chuan Liu, Lianhong Duan, Jianzheng Zhang, Zhicheng Zhang, Jie Gao, Yang Zhang, Tiansheng Sun   +9 more
doaj   +2 more sources

Formation of memory assemblies through the DNA-sensing TLR9 pathway

Nature
As hippocampal neurons respond to diverse types of information1, a subset assembles into microcircuits representing a memory2. Those neurons typically undergo energy-intensive molecular adaptations, occasionally resulting in transient DNA damage3–5. Here
Ana Cicvaric, Hui Zhang, Naoki Yamawaki
exaly   +2 more sources

IRAP+ endosomes restrict TLR9 activation and signaling [PDF]

Nature Immunology, 2017
The retention of intracellular Toll-like receptors (TLRs) in the endoplasmic reticulum prevents their activation under basal conditions. TLR9 is activated by sensing ligands in specific endosomal-lysosomal compartments. Here we identified IRAP+ endosomes as major cellular compartments for the early steps of TLR9 activation in dendritic cells (DCs ...
Delphyne Descamps, Aimé Cézaire Adiko, Sophia Maschalidi   +2 more
exaly   +7 more sources

TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk [PDF]

mBio
Toll-like receptors (TLRs) are transmembrane proteins that recognize microbial components or cellular danger signals and activate intracellular signaling pathways, leading to induction of anti-microbial and inflammatory genes.
Manoj Veleeparambil, Chenyao Wang, Patricia M. Kessler, Pracheta Sengupta, Santanu Das, Ritu Chakravarti, Belinda Willard, Ganes C. Sen, Saurabh Chattopadhyay   +8 more
doaj   +2 more sources

Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus

Nature Immunology, 2022
Kayla Thomas, Russell C Levack, Kensuke Miyake   +2 more
exaly   +2 more sources

TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes

EBioMedicine, 2019
Background TLR9 agonists are being developed as immunotherapy against malignancies and infections. TLR9 is primarily expressed in B cells and plasmacytoid dendritic cells (pDCs).
Line K Vibholm, Kathrine Kjær, Leila B Giron   +2 more
exaly   +2 more sources

Blocking Toll-like receptor 9 attenuates bleomycin-induced pulmonary injury [PDF]

Journal of Pathology and Translational Medicine, 2022
Background Acute respiratory distress syndrome (ARDS) is one of the most common complications in coronavirus disease 2019 patients suffering from acute lung injury (ALI). In ARDS, marked distortion of pulmonary architecture has been reported.
Badr Alzahrani, Mohamed M. S. Gaballa, Ahmed A. Tantawy, Maha A. Moussa, Salma A. Shoulah, Said M. Elshafae   +5 more
doaj   +1 more source

TLR9 gene expression in immune cells of patients with psoriasis

Consilium Medicum, 2022
Background. Psoriasis (skin lesions and psoriatic arthritis PA) is a chronic inflammatory autoimmune disease that can be triggered by excessive activation of endosomal toll-like receptors (TLRs), mainly TLR9. Elevated TLR9 levels are observed in both PA
Svetlana N. Chebysheva, Vladimir V. Sobolev, Elena V. Denisova, Anna G. Soboleva, Natalia A. Geppe, Irina M. Korsunskaya   +5 more
doaj   +1 more source

Expression of TLR9 and NF-κB in condyloma acuminatum

Pifu-xingbing zhenliaoxue zazhi, 2021
Objective To explore the expression and significance of TLR9 and NF-κB in condyloma acuminatum (CA). Methods The streptavidin-peroxidase (SP) immunohistochemistry method was used to measure the expression of TLR9 and NF-κB in 50 cases of CA and 20 normal
Guangwen YIN, Jiayin LIU, Jiadi YAN, Mengmeng GENG, Yidan ZHANG   +4 more
doaj   +1 more source